Article
Environmental Sciences
Yong-Sheng Wang, Sheng-Ji Yang, Muhammad Jamil Ahmad, Zhi-Ming Ding, Ze-Qun Duan, Yang-Wu Chen, Ming Liu, Ai-Xin Liang, Guo-Hua Hua, Li-Jun Huo
Summary: This study investigated the adverse effects of Zinc Pyrithione (ZPT) on mouse oocyte maturation and quality. The results showed that ZPT compromised oocyte maturation by disrupting meiotic cell cycle and causing cytoskeletal defects. In addition, ZPT altered epigenetic modifications and resulted in zinc accumulation, which further impaired the quality of oocytes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Chemistry, Multidisciplinary
Kei Yamada, Arghya Deb, Veronika M. Shoba, Donghyun Lim, Basudeb Maji, Ashley E. Modell, Amit Choudhary
Summary: We report a platform for the rapid development of ionophores using metal-ion chelators. The improved ionophores showed better specificity and performance for Zn-II, as well as superior antibacterial activity and lower toxicity to mammalian cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Editorial Material
Plant Sciences
Marc Hanikenne, Frederic Bouche
Summary: This article comments on a study that found the fine-tuning of Fe regulation by BRUTUS-LIKE (BTSL) E3 ligase negatively affects the Zn tolerance of plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Chemistry, Multidisciplinary
Abhimanew Dhir, Madhu Rajkumar, Gautam R. Desiraju
Summary: The accidental formation of Bandrowski's base, an oxidized trimer of p-phenylenediamine, a backbone molecule of the hair dye industry, in the presence of the antifungal/antidandruff agent clotrimazole, and the subsequent formation of a cocrystal, has the potential to lead to a new group of commercially important formulations.
Article
Marine & Freshwater Biology
Ye Zhao, Huiling Wang, Priscilla Agyemang Duah, Vladimir Retyunskiy, Yizheng Liu, Guoguang Chen
Summary: This study investigates the embryonic toxicogenomic responses induced by Zinc pyrithione (ZPT) in zebrafish. The results show that ZPT treatment causes embryogenesis toxicity, including irregular cell division and rearrangement, delayed differentiations of eyes and notochords, and defects in epiboly and germ ring formation and somite segmentation. ZPT exposure also alters gene expression during early embryonic development, leading to morphological abnormalities and metabolic dysfunctions. Additionally, ZPT induces oxidative stress, apoptosis, endoplasmic reticulum (ER) stress, and autophagy.
AQUATIC TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jesus Enrique Salcedo-Sora, Amy T. R. Robison, Jacqueline Zaengle-Barone, Katherine J. Franz, Douglas B. Kell
Summary: FepC and MetQ membrane transporters are involved in the uptake of pyrithione and its metal complexes, while CopA and ZntA efflux proteins drive the extrusion of copper and potentially zinc from bacterial cells to prevent toxic accumulation levels. The study highlights the important role of membrane transporters in facilitating drug uptake, including metal-drug compounds.
Article
Infectious Diseases
Cheryl Leong, Joyce Wang, Min Jet Toi, Yuen In Lam, Joleen Pz Goh, Shi Mun Lee, Thomas L. Dawson
Summary: The study confirmed the antifungal efficacy of zinc pyrithione in treating dandruff by inhibiting the growth of Malassezia on the scalp. These findings are valuable for investigating the role of Malassezia in skin microbiome intervention studies.
Review
Pharmacology & Pharmacy
Sean E. Mangion, Lorraine Mackenzie, Michael S. Roberts, Amy M. Holmes
Summary: This review discusses the topical products available for treating seborrheic dermatitis (SD) and their targeting of various aspects of the disease. Zinc pyrithione (ZnPT) based products that exhibit anti-fungal action are the market leaders. A skin compartment approach is presented for combining ZnPT exposure information with threshold levels for efficacy and toxicity, providing a comprehensive understanding of ZnPT therapeutics and safety. Successful SD treatment requires formulations that balance efficacy, safety, and consumer appeal.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Weihui Ou, Junda Shen, Jing Zhong, Jun He, Dangyuan Lei, Hongkun Li, Yingxian Chen, Chong Wang, Haikun Wu, Binbin Zhou, Xinxue Tang, Yulong Fan, Jian Lu, Yang Yang Li
Summary: The European Union has recently banned the use of zinc pyrithione (ZPT) in cosmetic products due to its potential health risk, which has raised the need for a reliable and convenient detection method. This study presents a highly sensitive method using surface-enhanced Raman spectroscopy (SERS) for on-site one-step detection of ZPT in real-life samples. The SERS sensor, produced by electrochemically treating commercial silver needles, allows for easy sampling and rapid identification of ZPT in shampoos within one minute using a portable Raman spectrometer.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Engineering, Environmental
Jinyuan Hu, Xu Luo, Mogellah John Panga, Clara Appiah, Vladimir Retyunskiy, Lin Zhu, Ye Zhao
Summary: Zinc pyrithione (ZPT) is widely used as an antifouling, antibacterial, and antifungal agent, but it has been shown to be toxic to marine life. However, there is limited research on the toxicity and toxicological mechanism of ZPT in the reproductive systems of aquatic organisms. Our study found that ZPT exposure caused various abnormalities in zebrafish sperm and testicular tissue, including decreased testosterone levels, sperm deformities, decreased sperm concentration and motility, and DNA damage in testicular tissue. We also identified potential mechanisms of ZPT-induced testicular injury through RNA-seq analysis of differentially expressed genes (DEGs).
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Plant Sciences
Yusuke Kakei, Hiroshi Masuda, Naoko K. Nishizawa, Hiroyuki Hattori, May Sann Aung
Summary: This study explored novel CREs and promoter structures in rice related to Fe excess, identified candidate CREs and conserved sequences, categorized different gene expression clusters in response to Fe excess, developed a new MAMA model to enhance known PLACE CREs' expression patterns, and integrated promoter structure design of Fe excess-responsive genes, providing valuable resources for further exploration of the Fe excess response mechanism.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Neurosciences
Milos Bogdanovic, Hila Asraf, Noa Gottesman, Israel Sekler, Elias Aizenman, Michal Hershfinkel
Summary: Tight regulation of neuronal Zn2+ is critical for physiological function. Multiple Zn2+ transporters, such as ZIP1 and ZIP3, are involved in the uptake and distribution of Zn2+. In this study, we found that the expression of ZIP1 and ZIP3 was developmentally regulated in mouse hippocampal neurons, with higher levels of expression in mature neurons. ZIP1 and ZIP3 were ubiquitously expressed on somas and most neuronal processes in cultured neurons, while in adult mouse hippocampal brain, ZIP1 was predominantly expressed in the CA3 stratum pyramidale, and ZIP3 primarily localized in the stratum lucidum. Silencing of ZIP1 or ZIP3 reduced Zn2+ uptake in vitro, and silencing of ZIP3 protected CA3 neurons from neurodegeneration following seizures in vivo. These findings suggest that distinct Zn2+ transporters play different roles in regulating Zn2+ accumulation and toxicity in different neuronal populations in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Microbiology
Jie Sun, Shiyi Xu, Yongbao Du, Kechen Yu, Yi Jiang, Hao Weng, Wei Yuan
Summary: Maintaining the balance of trace elements is crucial for organism health. Saccharomyces cerevisiae, as a widely used organism, can not only be used in various applications but also serve as a supplement for trace elements. Trace-element-enriched yeast, being more efficient, environmentally friendly, and safer than its counterparts, can provide a higher concentration of trace elements. Genetic engineering has the potential to further enhance the concentration of trace elements in yeast. This review explores different supplement forms of trace elements, mechanisms of detoxification and transport in yeast, as well as the feasibility, economy, safety, and future direction of trace-element-enriched yeast.
Article
Cell Biology
Michele Brischigliaro, Denis Badocco, Rodolfo Costa, Carlo Viscomi, Massimo Zeviani, Paolo Pastore, Erika Fernandez-Vizarra
Summary: The activity of cytochrome c oxidase (COX) depends on the incorporation of iron and copper into its catalytic centers. Many mitochondrial proteins are involved in the synthesis and delivery of metal-containing cofactors during COX biogenesis. Pathological variants in genes encoding structural subunits and assembly factors can lead to respiratory chain deficiency and mitochondrial disease. COX deficiency alters the homeostasis of transition metals, leading to changes in copper, iron, manganase, and zinc levels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Masaya Hitomi, Fumika Akizawa, Satoshi Kondo, Koji Dogishi, Sakura Fujiwara, Hiroki Kimoto, Takayasu Moroki
Summary: Zinc deficiency has adverse effects, and zinc complexes are commonly used as supplements but with few toxicity reports. In this study, zinc maltol (ZM) was administered orally to male rats for 4 weeks to evaluate its toxicity. Toxicities were observed at a dose of 1000 mg/kg, including pancreatitis, anemia, and decreased bone density, while no toxicities were observed in the ligand group. These findings provide helpful insights for the development of new zinc complexes and supplements.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
