期刊
JOURNAL OF BIOPHOTONICS
卷 8, 期 5, 页码 401-407出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201400025
关键词
Hyperspectral imaging supercontinuum nanoparticles biomarkers monoclonal antibody cancer stem cell
资金
- Le Fonds de recherche du Quebec - Nature et technologies
- Le Fonds de recherche du Quebec - Sante
We present a new hyperspectral reflected light microscopy system with a scanned broadband supercontinuum light source. This wide-field and low phototoxic hyperspectral imaging system has been successful for performing spectral three-dimensional (3D) localization and spectroscopic identification of CD44-targeted PEGylated AuNPs in fixed cell preparations. Such spatial and spectral information is essential for the improvement of nanoplasmonic-based imaging, disease detection and treatment in complex biological environment. The presented system can be used for real-time 3D NP tracking as spectral sensors, thus providing new avenues in the spatio-temporal characterization and detection of bioanalytes.
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