Article
Engineering, Electrical & Electronic
Xiangdong Ma, Mengzhi Fan, Yiqi Cai, Lijun Xu, Jianguo Ma
Summary: Photoacoustic imaging is a noninvasive and nonionizing imaging technique that provides high contrast and resolution. However, its sensing is currently limited by the bandwidth of piezoelectric ultrasound transducers. The use of optical ultrasound sensors based on Fabry-Perot interference is a promising alternative, but the parallel sensing and processing of ultrasound signals using fiber-optic ultrasound sensors remains a challenge.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Acoustics
Liuyang Yang, Dongchen Xu, Geng Chen, Anqi Wang, Liangye Li, Qizhen Sun
Summary: A miniaturized fiber optic ultrasound sensor is developed for multichannel parallel ultrasound detection and photoacoustic imaging. The sensor exhibits high sensitivity, omnidirectional directivity, and parallel detection capability. Experimental results demonstrate its performance in ultrasound detection and photoacoustic imaging.
Article
Engineering, Electrical & Electronic
Cong Du, Yanxue Wang, Litao Xu, Xingwei Wang
Summary: This letter presents a novel fiber optic imaging transducer for solving ultrasound steering problems for photoacoustic imaging. The transducer design is explored and verified based on photoacoustic effect and Fabry-Perot principle. Experimental results show that the transducer has a higher depth of penetration on ex vivo swine back rib muscle-fat slices.
IEEE PHOTONICS TECHNOLOGY LETTERS
(2022)
Article
Multidisciplinary Sciences
Jeongwoo Park, Byullee Park, Tae Yeong Kim, Sungjin Jung, Woo June Choi, Joongho Ahn, Dong Hee Yoon, Jeongho Kim, Seungwan Jeon, Donghyun Lee, Uijung Yong, Jinah Jang, Won Jong Kim, Hong Kyun Kim, Unyong Jeong, Hyung Ham Kim, Chulhong Kim
Summary: The study demonstrates a quadruple fusion imaging system that seamlessly integrates ultrasound imaging with photoacoustic imaging, optical coherence tomography, and fluorescence imaging using a spherically focused transparent ultrasound transducer. The system was used to monitor responses to chemical and suture injuries in rats' eyes, as well as for multimodal imaging of tumors in vivo. It is believed that this integrated multimodal system can have broad applications in ophthalmology, oncology, and beyond.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Optics
Bai-Ou Guan, Long Jin, Jun Ma, Yizhi Liang, Xue Bai
Summary: Photoacoustic imaging (PAI) technology has been developed to achieve multiscale imaging of biological samples using a flexible fiber-laser ultrasound sensor (FUS) based on optical fibers. The FUS allows for tuning of spatial ultrasound responses by bending the fiber laser, enabling wide-view optical-resolution photoacoustic microscopy and photoacoustic computed tomography at different depths. Compared to traditional rigid piezoelectric transducers, the flexible FUS provides the flexibility to design various multiscale PAI modalities.
OPTO-ELECTRONIC ADVANCES
(2021)
Article
Acoustics
Haemin Kim, Hohyeon Lee, Hyuncheol Kim, Jin Ho Chang
Summary: Photoacoustic imaging has been in the spotlight for its ability to provide optical contrast images of physiological information and deep imaging depth, but its sensitivity is limited by nontargeted signals and clutter artifacts. Researchers proposed a method to eliminate nontargeted signals using a dual-modal ultrasound-photoacoustic contrast agent and demonstrated improved visualization of target areas in photoacoustic images.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Multidisciplinary Sciences
Jingshun Pan, Qiang Li, Yaoming Feng, Ruifeng Zhong, Zhihao Fu, Shuixian Yang, Weiyuan Sun, Bin Zhang, Qi Sui, Jun Chen, Yuecheng Shen, Zhaohui Li
Summary: Photoacoustic tomography (PAT) is an attractive imaging modality that provides optical contrast with acoustic resolutions. In this work, we demonstrate PAT with a chalcogenide-based micro-ring sensor array and develop an effective means of parallel interrogation using a digital optical frequency comb.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Shang Gao, Yiwei Jiang, Mucheng Li, Yang Wang, Yao Shen, Matthew C. Flegal, Benjamin C. Nephew, Gregory S. Fischer, Yuxiang Liu, Loris Fichera, Haichong K. Zhang
Summary: We developed a flexible miniaturized photoacoustic imaging probe by modifying and incorporating custom-fabricated fibers into an ultrasound laparoscopic probe. The probe allows intraoperative detection of blood vessels and nerve bundles not directly visible, thus preserving these vital structures.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Physics, Multidisciplinary
Jialve Sun, Jia-Wei Meng, Shui-Jing Tang, Changhui Li
Summary: Ultrasonic sensors using two types of encapsulated microsphere resonators with different cavity materials were developed, achieving a noise equivalent pressure as low as 160 Pa at 20 MHz and an acoustic response up to 70 MHz at -6 dB. The microsensor was successfully used for photoacoustic microscopy to perform 3D imaging of hairs and leaf veins, showing considerable potential for near-field photoacoustic microscopy of micro/nanoscale objects and high-resolution endoscopic photoacoustic imaging.
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY
(2022)
Article
Chemistry, Analytical
Jihun Jang, Jinwoo Kim, Hak Jong Lee, Jin Ho Chang
Summary: The TRUS-PA probe, combining transrectal ultrasound and photoacoustic imaging, is able to visualize morphological changes and microvasculature distribution in the prostate, improving the quality of photoacoustic images.
Article
Acoustics
Christopher D. Nguyen, Skye A. Edwards, Tyler W. Iorizzo, Brooke N. Longo, Anna N. Yaroslavsky, David L. Kaplan, Srivalleesha Mallidi
Summary: This study proposes a silk protein-based hydrogel as a phantom material for ultrasound and photoacoustic imaging. The material can mimic the acoustic properties of various tissue types and exhibits similar optical scattering properties within a certain wavelength range. Furthermore, silk-based materials can be stored for long periods without changes in acoustic and optical properties, making them suitable for evaluating the performance of ultrasound and photoacoustic systems.
Article
Engineering, Electrical & Electronic
Maryam Basij, Andrei Karpiouk, Ira Winer, Stanislav Emelianov, Mohammad Mehrmohammadi
Summary: The study proposed a dual-mode illumination system that provides sufficient illumination to cervical tissue through internal and external light delivery strategies, leading to reliable photoacoustic imaging. System performance was tested using Monte Carlo simulations and validated with cervical tissue-mimicking phantoms.
IEEE PHOTONICS JOURNAL
(2021)
Article
Acoustics
Jun Ma, Jing Zhao, Huiwen Chen, Li-Peng Sun, Jie Li, Bai-Ou Guan
Summary: A transparent PDMS encapsulated optical microfiber ultrasound sensor was demonstrated for photoacoustic imaging, enabling scalable spatial resolution and penetration depth. The sensor comprised a microfiber loop with in-line Bragg gratings, allowing free delivery of ultrasound/light beams and unique needleshaped ultrasound focusing. With a detection limit of -700 Pa and a bandwidth of -10 MHz, the sensor was successfully applied for multiscale photoacoustic imaging of mouse vasculatures. Its advantages in flexibility, optical transparency, and focusing capability offer new opportunities for developing biomedical and clinical photoacoustic/ultrasound imaging devices.
Review
Radiology, Nuclear Medicine & Medical Imaging
Bo Fu, Yuan Cheng, Ce Shang, Jing Li, Gang Wang, Chenghong Zhang, Jingxuan Sun, Jianguo Ma, Xunming Ji, Boqu He
Summary: Optical ultrasound sensors are increasingly utilized in biomedical diagnosis and photoacoustic imaging due to their high sensitivity and resolution. Traditional ultrasound transducers face issues such as sensitivity reduction and electromagnetic interference, which optical sensors aim to overcome. These sensors are classified into resonant and non-resonant types, each with their own advantages and disadvantages for applications in PAI and structural imaging.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Optics
Jeremy Saucourt, Antonin Moreau, Julien Lumeau, Herve Rigneault, Thomas Chaigne
Summary: Optical detection of ultrasound for photoacoustic imaging using Fabry-Perot cavity sensors allows for higher spatial resolutions compared to conventional piezoelectric detection. However, precise control of the interrogation beam wavelength is required for optimal sensitivity. This study proposes the use of a broadband source and a fast-tunable acousto-optic filter to adjust the interrogation wavelength at each pixel within microseconds, overcoming fabrication constraints and improving acquisition speed.
Article
Physics, Applied
Peter Burgholzer, Michael Thor, Juergen Gruber, Guenther Mayr
JOURNAL OF APPLIED PHYSICS
(2017)
Article
Materials Science, Characterization & Testing
Irina Hinterlechner, Pere Barriobero-Vila, Bernhard Reitinger, Thomas Fromherz, Guillermo Requena, Peter Burgholzer
NONDESTRUCTIVE TESTING AND EVALUATION
(2018)
Article
Acoustics
Markus Haltmeier, Michael Sandbichler, Thomas Berer, Johannes Bauer-Marschallinger, Peter Burgholzer, Linh Nguyen
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2018)
Article
Materials Science, Characterization & Testing
Peter Burgholzer, Guenther Mayr, Juergen Gruber, Gregor Stockner
Article
Materials Science, Characterization & Testing
G. Mayr, G. Stockner, H. Plasser, G. Hendorfer, P. Burgholzer
NDT & E INTERNATIONAL
(2018)
Article
Mathematics, Applied
Oliver Lang, Peter Kovacs, Christian Motz, Mario Huemer, Thomas Berer, Peter Burgholzer
Article
Optics
Gregor Langer, Thomas Berer
Article
Imaging Science & Photographic Technology
Alexander Schager, Gerald Zauner, Guenther Mayr, Peter Burgholzer
JOURNAL OF IMAGING
(2020)
Article
Imaging Science & Photographic Technology
Peter Burgholzer, Johannes Bauer-Marschallinger, Bernhard Reitinger, Thomas Berer
JOURNAL OF IMAGING
(2019)
Proceedings Paper
Microscopy
J. Bauer-Marschallinger, A. Hoellinger, P. Torke, G. Paltauf, G. Haudum, B. Jakoby, P. Burgholzer, T. Berer
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2018
(2018)
Proceedings Paper
Microscopy
P. Burgholzer, C. Motz, O. Lang, T. Berer, M. Huemer
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2018
(2018)
Proceedings Paper
Microscopy
Guenther Paltauf, Paul Torke, Robert Nuster, Johannes Bauer-Marschallinger, Thomas Berer, Gerhard Haudum, Peter Burgholzer
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2018
(2018)
Proceedings Paper
Acoustics
P. Burgholzer, M. Haltmeier, T. Berer, E. Leiss-Holzinger, T. W. Murray
OPTO-ACOUSTIC METHODS AND APPLICATIONS IN BIOPHOTONICS III
(2017)
Proceedings Paper
Optics
Thomas Berer, Peter Burgholzer, Markus Haltmeier
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2017
(2017)
Proceedings Paper
Optics
P. Burgholzer, T. W. Murray, M. Haltmeier, E. Leiss-Holzinger, T. Berer
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2017
(2017)
