Article
Chemistry, Physical
Azole Sindelo, Pinar Sen, Tebello Nyokong
Summary: New tetra-substituted zinc and indium Schiff base phthalocyanines (ZnPc and InPc) were synthesized and characterized. Cationic derivatives of these Pcs were obtained by reacting ethyl pyrrolidine (ZnPc-2, InPc-2) and propyl pyrrolidine (ZnPc-3, InPc-3) substituted Schiff base Pcs with methyl iodide. The cationic Pcs exhibited higher singlet oxygen quantum yield in aqueous media and showed effective photoinactivation against Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive Staphylococcus aureus (MSSA) strains, depending on the singlet oxygen ability, charges, and alkyl group extension.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Jace A. Willis, Vsevolod Cheburkanov, Shaorong Chen, Jennifer M. Soares, Giulia Kassab, Kate C. Blanco, Vanderlei S. Bagnato, Paul de Figueiredo, Vladislav V. Yakovlev
Summary: The widespread use of antibiotics contributes to the evolution of antimicrobial-resistant bacteria, posing a threat to patients and healthcare professionals. Developing strategies to combat resistance is recognized as a global healthcare priority. In this study, a method using antimicrobial photodynamic therapy (aPDT) in conjunction with antibiotics is proposed to reduce resistance and extend the lifespan of current antibiotics. The results show that concurrent treatment of bacteria with antibiotics and aPDT significantly decreases the resistance of methicillin-resistant Staphylococcus aureus (MRSA) strains, suggesting a potential alternative for overcoming the challenge of growing MRSA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Acoustics
Yixuan Xu, Shiyang Liu, Hongyou Zhao, Yi Li, Chao Cui, Wenxin Chou, Yuxia Zhao, Jiyong Yang, Haixia Qiu, Jing Zeng, Defu Chen, Shengnan Wu, Yizhou Tan, Ying Wang, Ying Gu
Summary: Combining ultrasonic irradiation with antimicrobial photodynamic therapy (aPDT) enhances the efficacy of aPDT against MRSA biofilm by increasing the penetration depth of the photosensitizer (PS) and without affecting the viability of human dermal fibroblasts. This study suggests that the combination of aPDT and ultrasound is a potential and promising strategy for eradicating biofilm-associated infections of MRSA.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Microbiology
Alexandra E. Chittams-Miles, Areej Malik, Erin B. Purcell, Claudia Muratori, Brian Conlon
Summary: Treatment with short electric pulses can enhance the effects of multiple antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). This combination therapy reduces the necessary antibiotic dosage and improves the efficacy of treating S. aureus infections such as skin and soft-tissue infections (SSTIs). SSTIs are accessible to physical intervention, making electric pulse co-treatment a potential option for wound and abscess debridement.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Nuno M. M. Moura, Xavier Moreira, Eliana Sousa Da Silva, Joaquim Luis Faria, Maria G. P. M. S. Neves, Adelaide Almeida, Maria A. F. Faustino, Ana T. P. C. Gomes
Summary: Antimicrobial photodynamic therapy is a promising and innovative approach for the photoinactivation of microorganisms. This study demonstrates the excellent performance of porphyrin derivatives incorporated into materials for efficient photodynamic effect. These materials showed high efficacy in photoinactivating methicillin-resistant Staphylococcus aureus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Priyanga Dharmaratne, Ligang Yu, Roy Chi-Hang Wong, Ben Chun-Lap Chan, Kit-Man Lau, Baiyan Wang, Clara Bik-San Lau, Kwok-Pui Fung, Dennis Kee-Pui Ng, Margaret Ip
Summary: A novel dicationic boron dipyrromethene derivative showed high antibacterial photodynamic activity against MRSA strains and exhibited higher potency compared to methylene blue. The compound demonstrated potential therapeutic value in murine MRSA infected wound study.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Wei Xu, Elodi Dielubanza, Amanda Maisel, Kai Leung, Thomas Mustoe, Seok Hong, Robert Galiano
Summary: Chronic wounds are often caused by bacterial contamination, with Staphylococcus aureus being a common strain. Inhibition of keratinocyte migration by S. aureus exudate may involve the upregulation of connexin-43 (Cx43). The treatment of bacterium-infected wounds may be improved by targeting Cx43 and Akt to overcome wound closure impairment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Zhimin Bai, Min Chen, Qiaofa Lin, Ying Ye, Hongmei Fan, Kaizhen Wen, Jianxing Zeng, Donghong Huang, Wenfei Mo, Ying Lei, Zhijun Liao
Summary: By extracting feature vectors from protein sequences and using classification tools, MRSA and MSSA were successfully distinguished. MRSA showed high resistance to penicillin and high pathogenic risk. Cross-infection between different types of MRSA was found in Quanzhou, and MRSA in traditional hospitals exhibited increasingly blurred molecular characteristics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yunxing Fu, Chunqing Leng, Yuan Fan, Xia Ma, Xianghui Li, Xuefei Wang, Zhenghuan Guo, Xiujun Wang, Ruofeng Shang
Summary: DPTM, a new pleuromutilin derivative, showed potent antibacterial activity against MRSA and promoted wound healing in a murine skin infection model. It also decreased the secretion of inflammatory cytokines IL-6 and TNF-alpha in plasma. These results highlight the potential of DPTM as a novel antibacterial agent.
Article
Microbiology
Feifei Gu, Weiping He, Dedong Zhu, Peilang Yang, Jingyong Sun, Lizhong Han
Summary: This study investigated the epidemiology and features of MRSA in burn wound infections among burn patients in southeast China. The predominant clone found was ST239-III, but there was an increased diversity of MRSA clones in recent years.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Zhe Wang, Xingyun Liu, Yanwen Duan, Yong Huang
Summary: Research shows that hydrogels containing PTM nanoparticles can effectively treat skin infections caused by MRSA, not only exerting antibacterial effects but also accelerating wound healing, effectively treating subcutaneous tissue infections without toxicity.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Peng Zhao, Yu Zhang, Xiaoai Chen, Chang Xu, Jingzhe Guo, Meigui Deng, Xiongwei Qu, Pingsheng Huang, Zujian Feng, Jimin Zhang
Summary: Bacterial infection often leads to chronic wound healing due to increased inflammation. A versatile hydrogel dressing (rGB/QCS/PDA-PAM) with skin adaptiveness and mild photothermal antibacterial activity is developed for effective treatment of infected wounds. This hydrogel dressing has considerable potential in treating wounds infected with drug-resistant bacteria.
Article
Polymer Science
Jennifer Balcucho, Diana M. Narvaez, Natalia A. Tarazona, Jinneth Lorena Castro-Mayorga
Summary: Antimicrobial resistance is a major global health threat. In this study, bio-based silver and copper oxide nanoparticles were combined with a microbial-produced polyester to create bioactive films for the prevention and treatment of MRSA infections. These films showed strong antibacterial activity against MRSA and did not induce significant cytotoxicity or DNA damage in human fibroblast cells. These films also promoted platelet aggregation, which is beneficial for wound healing.
Article
Microbiology
Nada T. Felifel, Mahmoud A. Sliem, Zienat Kamel, Joanna Bojarska, Mohamed G. Seadawy, Rehab M. Amin, Sherif M. Elnagdy
Summary: Multidrug-resistant microorganisms pose a significant public health threat, and the use of traditional antibiotics is becoming less effective. Photodynamic therapy (PDT), which utilizes photosensitizers and light to generate Reactive Oxygen Species (ROS) for microorganism killing, shows promise as an alternative. Zinc phthalocyanine (ZnPc) is a potentially suitable photosensitizer due to its antimicrobial properties and ability to be encapsulated in nanoemulsions. In this study, a nanoemulsion was prepared using Miglyol 812N and distilled water, serving as an efficient nanocarrier system for hydrophobic drugs such as ZnPc. The results demonstrated that ZnPc encapsulated in the nanoemulsion significantly reduced cell survival percentages of Staphylococcus aureus and Escherichia coli, highlighting the potential of nanoemulsion-based PDT as an effective alternative for treating multidrug-resistant microorganisms.
Article
Biochemistry & Molecular Biology
Masaya Yokota, Nicola Haeffner, Matthew Kassier, Matthias Brunner, Srikanth Mairpady Shambat, Fabian Brennecke, Janine Schniering, Ewerton Marques Maggio, Oliver Distler, Annelies Sophie Zinkernagel, Britta Maurer
Summary: The study revealed that Staphylococcus aureus affects dermal fibroblasts, leading to impaired tissue repair functions such as upregulation of pro-inflammatory cytokines and degradation of collagen. This impact is not limited to specific cell sources and affects key mechanisms of wound healing.
Review
Dermatology
Jan Kyselovic, Jozef Masarik, Hayet Kechemir, Eva Koscova, Iva Igracki Turudic, Michael Richard Hamblin
Summary: Infrared light therapy has positive effects on relieving musculoskeletal pain through several mechanisms, including increasing nitric oxide availability and reducing inflammation.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Hamed Kowsari, Amirhossein Davoodvandi, Fatemeh Dashti, Seyed Mohamad Ali Mirazimi, Zahra Razaghi Bahabadi, Michael Aschner, Amirhossein Sahebkar, Hamid Reza Gilasi, Michael R. Hamblin, Hamed Mirzaei
Summary: Acute liver injury (ALI) is a critical and fatal disorder associated with excessive alcohol consumption. Despite advances in the early diagnosis and treatment of breast cancer, it remains a leading cause of cancer-related death in women worldwide. Phytochemicals, such as resveratrol, have shown promise in preventing and treating breast cancer. While resveratrol can affect various signaling pathways in vitro, its efficacy in animal models of breast cancer has been disappointing.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ming Zhong, Ghanbar Mahmoodi Chalbatani, Meifang Deng, Qiuyi Li, Elahe Gharagouzloo, Michael R. Hamblin, Eloah Rabello Suarez, Lili Hu, Dingding Wang
Summary: This study investigates the potential of CAR-T cells modified with a chimeric antigen receptor (CAR) targeting the vascular endothelial growth factor 2 receptor/kinase insert domain receptor (KDR) to destroy tumors. The results demonstrate the effectiveness of this CAR construct in inhibiting the growth of lung cancer and suggest its applicability as a new treatment strategy for other vascularized solid tumors.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Mohammad Shahpouri, Mohammad Amin Adili-Aghdam, Hossein Mahmudi, Mehdi Jaymand, Zohreh Amoozgar, Mohsen Akbari, Michael R. Hamblin, Rana Jahanban-Esfahlan
Summary: Hypoxia in solid tumors contributes to drug resistance, metastasis, and cancer relapse, but also provides an opportunity for targeting hypoxic tumor regions. This study discusses various strategies for dealing with hypoxia in deep-seated tumor cells, including their combination with other approaches like photodynamic therapy. The potential and limitations of these approaches, as well as current 3D hypoxia modeling systems, are also examined. Additionally, the potential and current status of preclinical tumor hypoxia approaches in clinical trials for advanced cancer are discussed.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Afshin Taheriazam, Ghazaleh Gholamiyan Yousef Abad, Shima Hajimazdarany, Mohammad Hassan Imani, Setayesh Ziaolhagh, Mohammad Arad Zandieh, Seyedeh Delaram Bayanzadeh, Sepideh Mirzaei, Michael R. Hamblin, Maliheh Entezari, Amir Reza Aref, Ali Zarrabi, Yavuz Nuri Ertas, Jun Ren, Romina Rajabi, Mahshid Deldar Abad Paskeh, Mehrdad Hashemi, Kiavash Hushmandi
Summary: Nanotechnology offers great potential in the field of nanomedicine for the treatment of various diseases, especially cancer. Graphene oxide nanoparticles have emerged as promising carbon-based nanocarriers for drug and gene delivery, photothermal therapy, overcoming chemotherapy resistance, and imaging. This review focuses on the biological functions of graphene oxide nanoparticles as regulators of apoptosis and autophagy, and their potential toxicity in major body organs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Psychiatry
Masoumeh Beheshti, Nikta Rabiei, Mohammad Taghizadieh, Pariya Eskandari, Samaneh Mollazadeh, Ehsan Dadgostar, Michael R. Hamblin, Arash Salmaninejad, Raziye Emadi, Amir Hossein Mohammadi, Hamed Mirazei
Summary: Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder characterized by intrusive thoughts and repetitive or ritualized actions. It is believed to have a genetic component, but the specific genetic factors involved are still unknown. This review summarizes the single nucleotide polymorphisms associated with OCD symptoms, early onset disease, neuroimaging results, and response to therapy. This information can help to understand the genetic basis of OCD, characterize individual patients, predict prognosis, and develop personalized treatment approaches.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Medicine, Research & Experimental
Seyed Mohammad Reza Hashemian, Amirhossein Sheida, Mohammad Taghizadieh, Mohammad Yousef Memar, Michael R. Hamblin, Hossein Bannazadeh Baghi, Javid Sadri Nahand, Zatollah Asemi, Hamed Mirzaei
Summary: Due to the lack of effective therapies for COVID-19, patients have to rely on supportive and nonspecific treatments. Certain proteins of SARS-CoV-2, such as 3 C-like protease (3CLpro) and major protease (Mpro), have been identified as potential targets for antiviral drugs. Nirmatrelvir, combined with ritonavir, has shown potent antiviral activity against SARS-CoV-2 variants, but there are still uncertainties regarding their efficacy, safety, and side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Ali Arash Anoushirvani, Arezoo Jafarian Yazdi, Sanaz Amirabadi, Sahar Ahmadi Asouri, Rana Shafabakhsh, Amirhossein Sheida, Maryam Sadat Hosseini Khabr, Ameneh Jafari, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Leila Kalantari, Sayyed Alireza Talaei Zavareh, Hamed Mirzaei
Summary: Neuroblastoma is the most common extracranial malignancy in childhood and is derived from neural crest. Non-coding RNAs (ncRNAs) have been found to play important roles in various cancers, including glioma and gastrointestinal cancers, by regulating cancer gene networks. Recent studies have shown that ncRNA genes are deregulated in human cancers through various mechanisms, and disturbances in their expression can act as either oncogenes or tumor suppressor genes, leading to the development of cancer. Moreover, ncRNAs can be secreted from tumor cells in exosomes and transferred to other cells, exerting their functions. However, further research is needed to fully understand the roles of ncRNAs in neuroblastoma.
CANCER GENE THERAPY
(2023)
Review
Genetics & Heredity
Alireza Farokhian, Ali Rajabi, Amirhossein Sheida, Amirhossein Abdoli, Moein Rafiei, Zahra Hadian Jazi, Sahar Ahmadi Asouri, Mohammad Amin Morshedi, Michael R. Hamblin, Parisa Adib-Hajbagheri, Hamed Mirzaei
Summary: ncRNAs, particularly miRNAs, lncRNAs, and circRNAs, play a significant role in regulating gene expression and affecting multiple cellular processes, especially apoptosis. Apoptosis has recently gained great interest as a therapeutic target to improve myocardial infarction outcomes. This review summarizes studies on ncRNAs that can promote or suppress apoptosis in the context of myocardial infarction, potentially introducing new therapeutic targets for its treatment.
Review
Chemistry, Physical
Houra Nekounam, Javad Malakootikhah, Donya Shaterabadi, Babak Negahdari, Mohammad Reza Kandi, Michael R. Hamblin
Summary: This article summarizes the advances in the preparation, optimization, and applications of silica nanoparticles in biomedical nanotechnology, as well as the inevitable human, environmental, and industrial contacts with these particles. Understanding the physicochemical properties of silica nanoparticles and their interactions with biological systems at the cellular level is crucial for the rational design of these particles. Control of toxicity risk can guide the design of silica nanoparticles for drug delivery and bioimaging systems.
Article
Microbiology
Carolina dos Anjos, Leon G. Leanse, Martha S. Ribeiro, Fabio P. Sellera, Milena Dropa, Victor E. Arana-Chavez, Nilton Lincopan, Mauricio S. Baptista, Fabio C. Pogliani, Tianhong Dai, Caetano P. Sabino
Summary: Antimicrobial drug development is under scrutiny due to the worldwide antibiotic crisis. Antimicrobial blue light (aBL) has been recognized as a potential therapy for infections, but the specific targets for bacterial killing by aBL are still poorly understood and may vary depending on the bacterial species.
MICROBIOLOGY SPECTRUM
(2023)
Correction
Nanoscience & Nanotechnology
Navid Rabiee, Mojtaba Bagherzadeh, Amir Mohammad Ghadiri, Yousef Fatahi, Abdullah Aldhaher, Pooyan Makvandi, Rassoul Dinarvand, Maryam Jouyandeh, Mohammad Reza Saeb, Masoud Mozafari, Mohammadreza Shokouhimehr, Michael R. Hamblin, Rajender S. Varma
ACS APPLIED BIO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Arefeh Ebadati, Mojgan Oshaghi, Sara Saeedi, Parastoo Parsa, Vahid Pirhajati Mahabadi, Morteza Karimi, Atefeh Jahandideh Hajiebrahimdehi, Michael R. Hamblin, Mahdi Karimi
Summary: Multi-drug resistant bacteria pose a significant challenge in the treatment of infectious diseases. Cationic nanopolymers, specifically poly(DABCO-BBAC) nanoparticles, exhibit high efficiency as antimicrobial agents. These nanoparticles effectively inhibit and kill multi-drug resistant Pseudomonas aeruginosa, making them a potential therapeutic option for drug-resistant clinical pathogens.
BIOORGANIC CHEMISTRY
(2023)
Review
Microbiology
Hanane Joudaki, Negar Aria, Roya Moravej, Mohamadreza Rezaei Yazdi, Zarrindokht Emami-Karvani, Michael R. Hamblin
Summary: Microbial phytases are enzymes that can break down phytic acid, providing several benefits in the food industry such as improved nutrient utilization, enhanced mineral bioavailability, and improved taste and functionality of food products. Factors like enzyme production and engineering techniques play a crucial role in effectively using microbial phytases.
CURRENT MICROBIOLOGY
(2023)
Article
Oncology
Przemys law Gnatowski, Edyta Pilat, Justyna Kucinska-Lipka, Mohammad Reza Saeb, Michael R. Hamblin, Masoud Mozafari
Summary: Cancerous tumors are highly fatal, claiming almost 10 million lives in 2020 worldwide. Accurately modeling tumors is a challenging task due to their complex and dynamic nature. Hydrogel-based 3D bioprinting is emerging as a promising approach to overcome the limitations of current models and mimic cancer development and behavior.
TRANSLATIONAL ONCOLOGY
(2023)
