Article
Biochemistry & Molecular Biology
Yan-Jyun Lin, Chien-Chung Yang, I-Ta Lee, Wen-Bin Wu, Chih-Chung Lin, Li-Der Hsiao, Chuen-Mao Yang
Summary: This study found that silica nanoparticles (SiNPs) can induce the expression of COX-2 and PGE(2) in human pulmonary alveolar epithelial cells (HPAEpiCs). The underlying mechanism may involve the activation of ROS/Pyk2/EGFR/PI3K/Akt/p38 MAPK and JNK1/2 signaling pathways, as well as the activation of FoxO1 and AP-1.
Article
Medicine, Research & Experimental
Zunyong Feng, Zhou Jing, Qiang Li, Liuxi Chu, YuXin Jiang, Xuanbo Zhang, Liang Yan, Yinhua Liu, Jing Jiang, Ping Xu, Qun Chen, Ming Wang, Hui Yang, Guoren Zhou, Xiaochun Jiang, Xiaoyuan Chen, Hongping Xia
Summary: Exosomes derived from AEC-IIs, called ADEs, can balance airway immunity and alleviate damage and fibrosis by regulating the immune and metabolic status of TRAMs. In a mouse fibrosis model, supplementation with ADEs reduced acute injury, prevented advanced fibrosis, alleviated ventilatory impairment, and decreased mortality.
Review
Instruments & Instrumentation
Yue Tan, Dawei Yu, Jiayao Feng, Huimin You, Yan Bai, Jincan He, Hua Cao, Qishi Che, Jiao Guo, Zhengquan Su
Summary: This review summarizes the existing literature on the toxicity assessment of silica nanoparticles (SiNPs), and identifies that the composition, physicochemical properties, administration route, frequency and duration of administration, and animal models' sex are related to their tissue and blood toxicity, immunotoxicity, and genotoxicity. However, the correlation between in vitro and in vivo toxicity has not been well established, mainly due to unrealistic dosages used in both cases. The article also discusses important factors to consider in SiNPs toxicology and current approaches to reducing their toxicity.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Environmental Sciences
Shanshan Hou, Xiayu Zhang, Haiying Du, Xiaofan Ning, Hao Wu, Chunrui Li, Yuxin Liu, Zhiwei Sun, Zhongjun Du, Minghua Jin
Summary: This study showed that with increasing concentrations of SiNPs, cell viability decreased, MMP decreased, ROS and Ca2+ levels increased in a dose-dependent manner. Additionally, the expression of UPR-related proteins such as PERK, GRP78 increased dose-dependently along with the expression of apoptosis proteins.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Na Xu, Wujie Lu, Lijie Meng, Xu Feng, Jingjing Xuan, Fangfang Liu, Zhijun Feng
Summary: The synthesized SiO2 nanoparticles showed potential activity in inhibiting carbonic anhydrase, antioxidant stress, and antibacterial effects, providing valuable information for the development of platforms for pneumonia treatment and management.
Article
Environmental Sciences
Tasnim Al Rashaideh, Nervana Metwali, Sarah S. Perry, Andrea Adamcakova-Dodd, Peter S. Thorne
Summary: This study examined the toxic effects of combining zinc oxide (ZnO) and cerium oxide (CeO2) in human lung epithelial cells. It was found that at non-toxic levels, CeO2 enhanced the toxicity of ZnO, resulting in cell membrane leakage and increased cytokine production.
Article
Chemistry, Multidisciplinary
Adam Coln Hundahl, Arjen Weller, Jannik Bruun Larsen, Claudia U. Hj, Morten B. Hansen, Ann-Kathrin Muendler, Astrid Knuhtsen, Kasper Kristensen, Eva C. Arnspang, Thomas Lars Andresen, Kim I. Mortensen, Rodolphe Marie
Summary: Oral drug delivery is the preferred administration route for most drugs, but it is limited for biologics due to the intestinal barrier. One strategy to improve the absorption is chemical modification through lipidation. However, the mechanistic understanding of the effect is largely unexplored. This study developed a method to quantify peptide transport through a monolayer of Caco-2 cells and investigated the effects of lipidation on transport mechanism.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Ghasem Rashidian, Ramin Mohammadi-Aloucheh, Farnaz Hosseinzadeh-Otaghvari, Latifeh Chupani, Vlastimil Stejskal, Hamidreza Samadikhah, Soheila Zamanlui, Cristiana Roberta Multisanti, Caterina Faggio
Summary: The study found that small-sized silica nanoparticles (SiO2-NPs) had negative effects on the reproductive performance of zebrafish, leading to decreased gonad weight, reduced fecundity, and lower larval survival rate. Additionally, SiO2-NPs significantly impacted the biochemical parameters, hormone levels, and immune function of zebrafish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Amirsadra Ahmadi, Moses Sokunbi, Trisha Patel, Ming-Wei Chang, Zeeshan Ahmad, Neenu Singh
Summary: This study statistically analyzed the factors influencing the biocompatibility and toxicity of Mesoporous Silica Nanoparticles (MSNs) in the past five years, including physicochemical properties, experimental conditions, and other experimental parameters.
Article
Nanoscience & Nanotechnology
Yi Guan, Nan Liu, Yan Yu, Qiang Zhou, Meiyu Chang, Yongheng Wang, Sanqiao Yao
Summary: Exposure to silica nanoparticles and indium-tin oxide nanoparticles caused different histopathological changes in rat lungs. The silica nanoparticle-induced model is more valuable for studying granulomas and fibrosis, while the indium-tin oxide nanoparticle-induced model has greater repeatability in the area of pulmonary alveolar proteinosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Analytical
Wenqian Wang, Yuanqing Ma, Simone Bonaccorsi, Vu Thanh Cong, Elvis Pandzic, Zhengmin Yang, Jesse Goyette, Fabio Lisi, Richard D. Tilley, Katharina Gaus, J. Justin Gooding
Summary: By utilizing phasor analysis, segmented scanned lines into subregions according to diffusion to address spatial heterogeneity of nanoparticles within cells. Phasor analysis can be used to select subpopulations for separate auto- and pair-correlation analysis. The method shows potential application in studying the diffusion of fluorescence-labeled nanoparticles within cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Gianni Jacucci, Brooke W. Longbottom, Christopher C. Parkins, Stefan A. F. Bon, Silvia Vignolini
Summary: Scattering enhancers are nanomaterials used in various materials, modifying the morphology of scattering elements to optimize scattering efficiency. Anisotropic sphero-cylindrical particles have been shown to outperform their isotropic counterparts, achieving excellent scattering performance across the visible electromagnetic spectrum.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Immunology
Ahmed A. Al-Qahtani, Ioanna Pantazi, Fatimah S. Alhamlan, Hani Alothaid, Sabine Matou-Nasri, George Sourvinos, Eleni Vergadi, Christos Tsatsanis
Summary: The study found that the S protein of SARS-CoV-2 suppresses inflammatory responses in alveolar epithelial type II cells at early stages of infection by activating the PI3K/AKT pathway. Additionally, when combined with TLR2 signals, the S protein enhances PAI-1 expression, potentially affecting the local coagulation cascade.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Toyoshi Yanagihara, Quan Zhou, Kazuya Tsubouchi, Spencer Revill, Anmar Ayoub, Mahsa Gholiof, Sy Giin Chong, Anna Dvorkin-Gheva, Kjetil Ask, Wei Shi, Martin RJ. Kolb
Summary: Type 1 alveolar epithelial cells (AT1s) and type 2 alveolar epithelial cells (AT2s) regulate the structural integrity and function of alveoli. Gremlin, an inhibitor of bone morphogenetic protein (BMP), induces AT2 proliferation and differentiation. It was found that Gremlin expression during lung injury leads to inhibition of BMP signaling and activation of AT2s, promoting alveolar repair.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Esther Marhuenda, Alvaro Villarino, Maria Leonor Narciso, Marta Camprubi-Rimblas, Ramon Farre, Nuria Gavara, Antonio Artigas, Isaac Almendros, Jorge Otero
Summary: One of the main limitations in in vitro studies on lung diseases is maintaining the specific phenotype of alveolar epithelial cells. This study successfully maintained the phenotype of cells using lung-derived extracellular matrix hydrogels, and found that the hydrogels can promote long-term culture of alveolar epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Correction
Engineering, Biomedical
Ksenia Astanina, Yvette Simon, Christian Cavelius, Sandra Petry, Annette Kraegeloh, Alexandra K. Kiemer
ACTA BIOMATERIALIA
(2015)
Article
Chemistry, Inorganic & Nuclear
Eva Hemmer, Christian Cavelius, Volker Huch, Sanjay Mathur
INORGANIC CHEMISTRY
(2015)
Article
Engineering, Biomedical
Ksenia Astanina, Yvette Simon, Christian Cavelius, Sandra Petry, Annette Kraegeloh, Alexandra K. Kiemer
ACTA BIOMATERIALIA
(2014)
Article
Materials Science, Multidisciplinary
Michael Veith, Karsten Moh, Christian Cavelius
ADVANCED ENGINEERING MATERIALS
(2012)
Article
Chemistry, Physical
Sabrina Schuebbe, Christian Schumann, Christian Cavelius, Marcus Koch, Tobias Mueller, Annette Kraegeloh
CHEMISTRY OF MATERIALS
(2012)
Article
Chemistry, Multidisciplinary
Christian Cavelius, Karsten Moh, Sanjay Mathur
CRYSTAL GROWTH & DESIGN
(2012)
Article
Biotechnology & Applied Microbiology
Enio Lima, Giancarlo E. S. Brito, Christian Cavelius, Vladimir Sivakov, Hao Shen, Sanjay Mathur, Gerardo F. Goya
CURRENT NANOSCIENCE
(2012)
Article
Pharmacology & Pharmacy
Britta Diesel, Jessica Hoppstaedter, Nina Hachenthal, Robert Zarbock, Christian Cavelius, Birgit Wahl, Nicolas Thewes, Karin Jacobs, Annette Kraegeloh, Alexandra K. Kiemer
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2013)
Article
Biochemistry & Molecular Biology
Melanie Kucki, Christian Cavelius, Annette Kraegeloh
Article
Nanoscience & Nanotechnology
Michael Busse, David Stevens, Annette Kraegeloh, Christian Cavelius, Mathias Vukelic, Eduard Arzt, Daniel J. Strauss
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2013)
Article
Chemistry, Multidisciplinary
Marcus Koch, Silke Kiefer, Christian Cavelius, Annette Kraegeloh
JOURNAL OF NANOPARTICLE RESEARCH
(2012)
Article
Chemistry, Multidisciplinary
Philip Born, Andres Munoz, Christian Cavelius, Tobias Kraus
Article
Chemistry, Applied
Eva Hemmer, Izumi Kumakiri, Nicolas Lecerf, Rune Bredesen, Sven Barth, Jessica Altmayer, Nicole Donia, Christian Cavelius, Kohei Soga, Sanjay Mathur
MICROPOROUS AND MESOPOROUS MATERIALS
(2012)
Article
Chemistry, Physical
Katharina Boese, Marcus Koch, Christian Cavelius, Alexandra K. Kiemer, Annette Kraegeloh
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2014)