期刊
JOURNAL OF BIOPHOTONICS
卷 4, 期 11-12, 页码 840-849出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201100073
关键词
Two-dimensional CCD imaging; skin; reactive oxygen species; ultra-weak photon emission
资金
- Centre of the region Hana for biotechnological and agricultural research [CZ.1.05/2.1.00/01.0007]
- Ministry of Education, Youth and Sports of Czech Republic [MSM6198959215]
- Palacky University [PrF_2011_024]
In the human skin, reactive oxygen species (ROS) produced continuously during oxidative metabolic processes (cellular respiration, oxidative burst) are essential for various cellular processes such as defense against infection, cellular signaling and apoptosis. On the other hand, when the formation of ROS exceeds a capacity of the non-enzymatic and the enzymatic antioxidant defense system, ROS cause the damage to the human skin known to initiate premature skin aging and skin cancer. In this study, two-dimensional spontaneous ultra-weak photon emission from the human skin has been measured using a highly sensitive charged coupled device (CCD) camera. It is demonstrated here that two-dimensional ultra-weak photon emission from the human skin increases with the topical application of exogenous ROS in the following order: hydrogen peroxide (H2O2) < superoxide anion radical (O-2(center dot-)) < hydroxyl radical (HO center dot). [GRAPHICS] We propose here that the two-dimensional ultra-weak photon emission can be used as a non-invasive tool for the spatial and temporal monitoring of oxidative stress
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