期刊
ANTIVIRAL RESEARCH
卷 122, 期 -, 页码 20-27出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2015.07.009
关键词
HIV-1; Vif; APOBEC3G; Elongin C; ZBMA-1
资金
- National Special Research Program for Important Infectious Diseases [2013ZX10001004]
- Guangdong Recruitment Program of Creative Research Groups [2009010058]
- National Basic Research Program of China (973 Program) [2010CB912202]
- National Natural Science Foundation of China [30972620]
- Natural Science Foundation of Guangdong [9251008901000022]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20090171110083]
- Guangdong Natural Science Foundation New Ph.D. Start-up [S20212040006494]
HIV-1 Vif protein is one of the most crucial accessory proteins for viral replication. It efficiently counteracts the important host restriction factor APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G, A3G) which is lethal to HIV-1 by causing G to A mutation of viral genome. Vif protein mediates degradation of APOBEC3G via the complicated protein-protein interactions of Vif, APOBEC3G, Elongin C/B and Cullin 5. The importance of Vif-APOBEC3G complex makes it a good potential target to develop new therapeutics of HIV-1. We identified a potent HIV-1 replication inhibitor (ZBMA-1, IC50 = 1.01 mu M) that efficiently protected APOBEC3G protein by targeting Vif-APOBEC3G complex. The co-immunoprecipitation and docking studies indicated that compound ZBMA-1 affected the binding of Elongin C with Vif protein. (C) 2015 Elsevier B.V. All rights reserved.
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