期刊
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
卷 -, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2012/580687
关键词
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资金
- Natural Science Foundation of Shanghai Jiaotong University School of Medicine, China [11XJ21056]
- Science and Technology Commission of Shanghai Municipality, China [11BA1409700]
- Shanghai Jiaotong University, China [YG2011MS11]
Diabetic retinopathy (DR) is a major cause of blindness in working age adults, and oxidative stress plays a vital role in the pathogenesis of DR. Pigment-epithelium-derived factor (PEDF), a multifunctional protein, has shown to inhibit the development of DR by accumulating evidence. This paper highlights the current understanding of probable mechanism about how PEDF blocks the deterioration of DR through its antioxidative properties and application prospects of PEDF as a novel therapeutic target in DR. Gene therapy of PEDF is becoming more and more acceptable and will widely be applied to the actual treatment in the near future.
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