Emerging Role for Epithelial Polarity Proteins of the Crumbs Family as Potential Tumor Suppressors

Epithelial cell polarity and tumorigenesis: new perspectives for cancer detection and treatment

(2011) Danila Coradini et al.   ACTA PHARMACOLOGICA SINICA

The Hippo pathway and apico–basal cell polarity

(2011) Alice Genevet et al.   BIOCHEMICAL JOURNAL

Junctions gone bad: Claudins and loss of the barrier in cancer

(2011) Kursad Turksen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Liver Kinase B1 (LKB1) in the pathogenesis of epithelial cancers

(2011) Jennifer L. Herrmann et al.   CANCER LETTERS

ZEB proteins link cell motility with cell cycle control and cell survival in cancer

(2011) Gareth Browne et al.   CELL CYCLE

Dual Roles of Notch in Regulation of Apically Restricted Mitosis and Apicobasal Polarity of Neuroepithelial Cells

(2011) Shinya Ohata et al.   NEURON

Novel insights into epithelial polarity proteins in Drosophila

(2011) Patrick Laprise et al.   TRENDS IN CELL BIOLOGY

Role of Notch and its oncogenic signaling crosstalk in breast cancer

(2010) Shanchun Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion

(2010) Y Wu et al.   BRITISH JOURNAL OF CANCER

aPKC Phosphorylation of Bazooka Defines the Apical/Lateral Border in Drosophila Epithelial Cells

(2010) Eurico Morais-de-Sá et al.   CELL

Crumbs/DaPKC-Dependent Apical Exclusion of Bazooka Promotes Photoreceptor Polarity Remodeling

(2010) Rhian F. Walther et al.   CURRENT BIOLOGY

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

(2010) Nicola A. Grzeschik et al.   CURRENT BIOLOGY

Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded

(2010) Brian S. Robinson et al.   CURRENT BIOLOGY

Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators

(2010) Ling Huang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Crumbs is required to achieve proper organ size control during Drosophila head development

(2010) E. C. N. Richardson et al.   DEVELOPMENT

Alternative splicing of SMADs in differentiation and tissue homeostasis

(2010) Shijie Tao et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Human CRB2 Inhibits γ-Secretase Cleavage of Amyloid Precursor Protein by Binding to the Presenilin Complex

(2010) Yachiyo Mitsuishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adherens junctions: from molecules to morphogenesis

(2010) Tony J. C. Harris et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

(2010) C. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

(2010) C.-L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Snail

(2010) Yadi Wu et al.   Cell Adhesion & Migration

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Epithelial Polarity Proteins Regulate Drosophila Tracheal Tube Size in Parallel to the Luminal Matrix Pathway

(2009) Patrick Laprise et al.   CURRENT BIOLOGY

Herding Hippos: regulating growth in flies and man

(2009) Caroline Badouel et al.   CURRENT OPINION IN CELL BIOLOGY

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

(2009) Noriyuki Nishioka et al.   DEVELOPMENTAL CELL

The FERM-Domain Protein Expanded Regulates Hippo Pathway Activity via Direct Interactions with the Transcriptional Activator Yorkie

(2009) Caroline Badouel et al.   DEVELOPMENTAL CELL

Independent cadherin–catenin and Bazooka clusters interact to assemble adherens junctions

(2009) Melanie A. McGill et al.   JOURNAL OF CELL BIOLOGY

The Hippo pathway regulates apical-domain size independently of its growth-control function

(2009) A. Genevet et al.   JOURNAL OF CELL SCIENCE

The Crumbs complex: from epithelial-cell polarity to retinal degeneration

(2009) N. A. Bulgakova et al.   JOURNAL OF CELL SCIENCE

Yurt, Coracle, Neurexin IV and the Na+,K+-ATPase form a novel group of epithelial polarity proteins

(2009) Patrick Laprise et al.   NATURE

Involvement of Members of the Cadherin Superfamily in Cancer

(2009) G. Berx et al.   Cold Spring Harbor Perspectives in Biology

The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

(2008) S. Spaderna et al.   CANCER RESEARCH

Role of the Polarity Determinant Crumbs in Suppressing Mammalian Epithelial Tumor Progression

(2008) C. M. Karp et al.   CANCER RESEARCH

Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

(2008) Lixing Zhan et al.   CELL

A crucial role of WW45 in developing epithelial tissues in the mouse

(2008) Joo-Hyeon Lee et al.   EMBO JOURNAL

Cdc42 and Par proteins stabilize dynamic adherens junctions in theDrosophilaneuroectoderm through regulation of apical endocytosis

(2008) Kathryn P. Harris et al.   JOURNAL OF CELL BIOLOGY

Multiple domains of Stardust differentially mediate localisation of the Crumbs-Stardust complex during photoreceptor development in Drosophila

(2008) N. A. Bulgakova et al.   JOURNAL OF CELL SCIENCE

The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes

(2008) E L Whiteman et al.   ONCOGENE

The Hippo Pathway Promotes Notch Signaling in Regulation of Cell Differentiation, Proliferation, and Oocyte Polarity

(2008) Jianzhong Yu et al.   PLoS One