Article
Medicine, Research & Experimental
Lujing Jiang, Xiaojian Yin, Ya-Hui Chen, Yan Chen, Wei Jiang, Hao Zheng, Feng-Qing Huang, Baolin Liu, Wei Zhou, Lian-Wen Qi, Jia Li
Summary: Ginsenoside Rb1 attenuates cardiac ischemia/reperfusion (I/R) injury by inhibiting reactive oxygen species (ROS) production from mitochondrial complex I. It reduces myocardial infarct size, preserves cardiac function, and limits cardiac fibrosis. The mechanism involves inhibition of complex I-mediated ROS burst.
Article
Plant Sciences
Jian Ye, Tian-Jiao Lyu, Ling-Yan Li, Ying Liu, Hong Zhang, Xu Wang, Xin Xi, Zong-Jun Liu, Jun-Qing Gao
Summary: This study investigates the protective mechanism of Ginsenoside Re and the role of ferroptosis in myocardial ischemia/reperfusion injury. The findings suggest that Ginsenoside Re attenuates ferroptosis induced by myocardial ischemia/reperfusion through the miR-144-3p/SLC7A11 pathway, thereby reducing cardiac damage.
Article
Integrative & Complementary Medicine
Guo-Wei Qin, Pan Lu, Li Peng, Wei Jiang
Summary: The study found that Ginsenoside Rb1 alleviated MIRI in rats and protected H9C2 cells against hypoxia/reoxygenation-induced damage. Ginsenoside Rb1 inhibited the autophagy process induced by MIRI, exerted protective effects through the PI3K/Akt/mTOR signaling pathway, and contributed to reducing cardiomyocyte apoptosis.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Weijie Xie, Xinyue Wang, Tianbao Xiao, Yibo Cao, Yumei Wu, Dongsheng Yang, Song Zhang
Summary: Ginseng Rb1 has significant neuroprotective effects on cerebral ischemic injury, with mechanisms involving antioxidant, anti-inflammatory, and antiapoptotic activities, as well as inhibition of excitotoxicity and Ca2(+) influx, preservation of blood-brain barrier integrity, and maintenance of energy metabolism. As a result, GRb1 has the potential to be a candidate drug for treating ischemic stroke.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lu Tang, Yun-peng Li, Juan Hu, Ai-hua Chen, Yingli Mo
Summary: Dexpramipexole (DPX) protects against myocardial injury induced by ischemia/reperfusion (I/R) by enhancing mitophagy through increased expression of PINK1 and Parkin.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Xiangrong Cui, Hongping Liang, Chonghua Hao, Xuan Jing
Summary: Liraglutide protects cardiomyocytes under hypoxia/reoxygenation conditions by regulating homer1 gene expression, inhibiting intracellular calcium overload, and enhancing cell survival.
Article
Plant Sciences
Jingui Hu, Ling Zhang, Fei Fu, Qiong Lai, Lu Zhang, Tao Liu, Boyang Yu, Junping Kou, Fang Li
Summary: Ginsenoside Rb1 protects against acute myocardial ischemia injury by promoting mitophagy via AMPKa phosphorylation.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Xinyu Zhang, Lei Wang, Rong Guo, Jie Xiao, Xiaoling Liu, Mei Dong, Xiaorong Luan, Xiaoping Ji, Huixia Lu
Summary: Rb1 has shown promising results in alleviating arterial stiffness induced by diabetes, improving aortic compliance and endothelium-dependent vasodilation. Additionally, Rb1 can ameliorate aortic remodeling in diabetes by influencing MMP2, MMP9, and TGF beta 1/Smad2/3 pathways. It is also suggested that Rb1 may inhibit oxidative stress and enhance AMPK phosphorylation as potential mechanisms for improving arterial stiffness in diabetes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zekun Cui, Lifei Gu, Tao Liu, Yining Liu, Boyang Yu, Junping Kou, Fang Li, Kun Yang
Summary: Ginsenoside Rd alleviates myocardial ischemia injury by improving mitochondrial biogenesis via the WNT5A/Ca2+ pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Eliana P. Bin, Tamara Zaobornyj, Mariana Garces, Veronica D'Annunzio, Bruno Buchholz, Timoteo Marchini, Pablo Evelson, Ricardo J. Gelpi, Martin Donato
Summary: The rupture of the plasma membrane is the key point in cell death, which can be prevented by remote ischemic preconditioning through inhibiting MMP-2 activity. Besides, remote ischemic preconditioning also improves mitochondrial function, increasing membrane potential, ATP production and respiratory control.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Zhihan Chen, Jingping Wu, Sijing Li, Caijiao Liu, Yulan Ren
Summary: Ischemic heart disease is a fatal condition, and reperfusion is the recommended therapy. However, restoring blood flow to ischemic tissue can cause myocardial ischemia/reperfusion injury (MIRI). Apoptosis is a crucial factor in MIRI, and ginsenosides have shown effectiveness in inhibiting apoptosis and alleviating MIRI. In this review, we examined published studies on the anti-apoptotic effects of ginsenosides and their mechanisms of action in improving MIRI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Leilei Ma, Hongtao Shi, Yang Li, Wei Gao, Junjie Guo, Jianbing Zhu, Zheng Dong, Aijun Sun, Yunzeng Zou, Junbo Ge
Summary: Short-term nonischemic hypertrophic preconditioning renders the heart resistant to subsequent ischemic stress, reducing myocardial infarct size, apoptosis, and improving contractile function. This preconditioning alleviates oxidative stress, inhibits caspase-3 activation, and improves mitochondrial function through SIRT3-dependent IDH2 deacetylation, providing a novel cardioprotective strategy for cardiac ischemia/reperfusion injury.
Article
Physiology
Caitlin P. Jarrard, Mercedes J. Nagel, Sten Stray-Gundersen, Hirofumi Tanaka, Sophie Lalande
Summary: Ischemic preconditioning and intermittent hypoxia can attenuate the reduction in brachial artery endothelial function caused by ischemia-reperfusion injury in young healthy individuals.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Integrative & Complementary Medicine
Jing-Hua Zhang, Hui-Zeng Yang, Hao Su, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Zhong Zhen, Yao Lu
Summary: The study demonstrated that berberine and ginsenoside Rb1 improved glucose metabolism and depression-like behavior in diabetic rats, while also protecting neurons from pathological changes. The combination of these two compounds may have clinical value for diabetic patients with depression.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Endocrinology & Metabolism
Li-Ming Yu, Xue Dong, Xiao-Dong Xue, Shu Xu, Xu Zhang, Yin-Li Xu, Zhi-Shang Wang, Yang Wang, Hao Gao, Yan-Xiao Liang, Yang Yang, Hui-Shan Wang
Summary: Targeting mitochondrial quality control with melatonin shows promise in attenuating diabetic cardiomyopathy. Activation of SIRT6 and melatonin membrane receptors exerts cardioprotective effects, playing a key role in preserving mitochondrial quality control. Long-term melatonin treatment may be a promising strategy for diabetic patients in reducing myocardial vulnerability to ischemia-reperfusion injury.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yanli Yu, Haibin Fang, Zhen Qiu, Zhongyuan Xia, Bin Zhou
NEUROCHEMICAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Wenyuan Li, Wei Li, Yan Leng, Yonghong Xiong, Rui Xue, Rong Chen, Zhongyuan Xia
BIOSCIENCE REPORTS
(2020)
Article
Anesthesiology
Rong Chen, Yuan Zhang, Lei Huang, Bi-heng Cheng, Zhong-yuan Xia, Qing-tao Meng
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2020)
Article
Cell Biology
Xia Pan, Cheng Shen, Yayi Huang, Long Wang, Zhongyuan Xia
MEDIATORS OF INFLAMMATION
(2020)
Article
Cell Biology
Rong Chen, Yun-yan Zhang, Jia-nan Lan, Hui-min Liu, Wei Li, Yang Wu, Yan Leng, Ling-hua Tang, Jia-bao Hou, Qian Sun, Tao Sun, Zi Zeng, Zhong-yuan Xia, Qing-tao Meng
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Endocrinology & Metabolism
Yafeng Wang, Lu Zhou, Wating Su, Fengnan Huang, Yuan Zhang, Zhong-yuan Xia, Zhengyuan Xia, Shaoqing Lei
JOURNAL OF DIABETES RESEARCH
(2020)
Article
Clinical Neurology
Wen-Qin Song, Wei Wang, Ying-Cong Yang, Qian Sun, Hui Chen, Lei Zhang, Xue-Shan Bu, Li-Ying Zhan, Zhong-Yuan Xia
JOURNAL OF PAIN RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Rong Chen, Zi Zeng, Yun-yan Zhang, Chen Cao, Hui-min Liu, Wei Li, Yang Wu, Zhong-yuan Xia, Daqing Ma, Qing-tao Meng
Article
Chemistry, Multidisciplinary
Zong-jun Xia, Yin-chun Ji, De-qiao Sun, Xia Peng, Ying-lei Gao, Yan-fen Fang, Xing-dong Zhao, Wei-bo Wang, Jian Ding, Mei-yu Geng, Jing Ai
Summary: SAF-189s, a novel ROS1/ALK inhibitor, shows promising antitumor efficacy against both wild-type and crizotinib-resistant mutants of ROS1 fusion, indicating its potential for treating patients with the G2032R mutation and its recruitment in a phase II clinical trial for NSCLC patients.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Kefan Wu, Lili Chen, Zhen Qiu, Bo Zhao, Jiabao Hou, Shaoqin Lei, Meng Jiang, Zhongyuan Xia
Summary: SAH induces cellular stress and ER stress, leading to the activation of UPR in nerve cells. IRE1 plays a critical role in cellular stress response and its final product Xbp1s is essential for adaptation to external changes. Investigating the IRE1/XBP1s/GFAT1 axis could offer a promising avenue for future research.
Review
Infectious Diseases
Aining Zhang, Yan Leng, Yi Zhang, Kefan Wu, Yelong Ji, Shaoqing Lei, Zhongyuan Xia
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Letter
Medicine, General & Internal
Shaoqing Lei, Fang Jiang, Zhong-Yuan Xia, Zhengyuan Xia
Article
Surgery
Zeng Cheng, Sun Qian, Meng Qingtao, Xia Zhongyuan, Xiao Yeda
ACTA CIRURGICA BRASILEIRA
(2020)
Article
Surgery
Chen Cao, Hui-min Liu, Wei Li, Yang Wu, Yan Leng, Rui Xue, Rong Chen, Ling-hua Tang, Qian Sun, Zhongyuan Xia, Qi-zhu Tang, Di-fei Shen, Qing-tao Meng
ACTA CIRURGICA BRASILEIRA
(2020)
Article
Cell Biology
Shan-Shan Cui, Xiao-Bo Fong, Bing-Hong Zhang, Zhong-Yuan Xia, Li-Ying Zhan
NEURAL REGENERATION RESEARCH
(2020)