Article
Immunology
Graziele Quintela-Carvalho, Astrid Madeleine Calero Goicochea, Vanessa Mancur-Santos, Sayonara de Melo Viana, Yasmin da Silva Luz, Beatriz Rocha Simoes Dias, Milena Lazaro-Souza, Martha Suarez, Camila Indiani de Oliveira, Elvira M. Saraiva, Claudia Brodskyn, Patricia T. Veras, Juliana P. B. de Menezes, Bruno B. Andrade, Jonilson Berlink Lima, Albert Descoteaux, Valeria M. Borges
Summary: Lipophosphoglycan (LPG) may play a critical role in promoting Leishmania survival in human neutrophils through cellular activation and generation of free radicals, thereby influencing the process of infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Jyoti Pant, Marie Samanovic, Maria T. Nelson, Mert K. Keceli, Joseph Verdi, Stephen M. Beverley, Jayne Raper
Summary: TLF is a primate-specific high-density lipoprotein complex that provides innate immunity against kinetoplastid parasites. TLF was shown to bind to the surface of metacyclic promastigotes of L. major, reducing the parasite burden, but this effect was lost in neutrophil-depleted mice.
Article
Oncology
Tobias Mohr, Anabel Zwick, Muriel Charlotte Hans, Isabelle Ariane Bley, Felix Leon Braun, Oybek Khalmurzaev, Vsevolod Borisovich Matveev, Philine Loertzer, Alexey Pryalukhin, Arndt Hartmann, Carol-Immanuel Geppert, Hagen Loertzer, Heiko Wunderlich, Carsten Maik Naumann, Holger Kalthoff, Kerstin Junker, Sigrun Smola, Stefan Lohse
Summary: Currently, there are no recommended biomarkers for the routine diagnosis of penile carcinoma (PeCa). However, the rising incidence of this HPV-related cancer highlights the need for potential biomarkers. This study investigated the expression of Calprotectin subunits S100A8 and S100A9, as well as their receptor CD147, in PeCa specimens. The researchers found that an elevated expression of S100A8 and S100A9, along with a positive HPV status, was associated with a higher risk of metastasis. Additionally, an elevated expression of CD147 in HPV-positive PeCa cell lines was correlated with reduced susceptibility to neutrophil-mediated tumor cell killing. Stratifying patients based on their HPV/S100A8/S100A9/CD15/CD147 profile could help identify those with progressing cancer and guide immunotherapeutic treatment strategies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sajad Rashidi, Reza Mansouri, Mohammad Ali-Hassanzadeh, Antonio Muro, Paul Nguewa, Raul Manzano-Roman
Summary: The complement system plays a crucial role in the immune response against pathogens. However, parasites have developed strategies to evade complement killing and utilize the system to their advantage. In this study, the interaction mechanisms between infectious protozoan parasites, such as Plasmodium, Toxoplasma, Trypanosoma, and Leishmania, and the complement system are investigated. The roles of key proteins expressed, recruited, or hijacked by parasites in modulating the host's complement system are discussed, with a focus on efficient complement killing or evasion. Parasite complement regulatory proteins are also identified as potential therapeutic and vaccine targets for protozoan parasitic infections. Perspectives and insights for future investigations are suggested.
Article
Infectious Diseases
Thamara K. F. Oliveira, Jullyanna Oliveira-Silva, Leandra Linhares-Lacerda, Vanderlei da Silva Fraga-Junior, Claudia F. Benjamim, Anderson B. Guimaraes-Costa, Elvira M. Saraiva
Summary: This study characterizes the pathways involved in the formation of NETs induced by axenic amastigotes from L. infantum, improving our understanding of the signaling pathways implicated in the interaction between amastigotes and human neutrophils.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Biology
Subir Karmakar, Nevien Ismail, Fabiano Oliveira, James Oristian, Wen Wei Zhang, Swarnendu Kaviraj, Kamaleshwar P. Singh, Abhishek Mondal, Sushmita Das, Krishna Pandey, Parna Bhattacharya, Greta Volpedo, Sreenivas Gannavaram, Monika Satoskar, Sanika Satoskar, Rajiv M. Sastry, Claudio Meneses, Shinjiro Hamano, Pradeep Das, Greg Matlashewski, Sanjay Singh, Shaden Kamhawi, Ranadhir Dey, Jesus G. Valenzuela, Abhay Satoskar, Hira L. Nakhasi
Summary: Karmakar et al. developed a dermotropic, live attenuated centrin gene-deleted Leishmania major (LmCen(-/-)) vaccine against Visceral Leishmaniasis (VL), demonstrating that a single intradermal injection provides robust and durable protection against lethal VL transmitted through sand fly bites.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Miriam Algarabel, Celia Fernandez-Rubio, Katerina Musilova, Jose Pena-Guerrero, Andres Vacas, Esther Larrea, Paul A. Nguewa
Summary: Leishmaniasis is caused by Leishmania spp. and improving treatments and discovering new drugs are major goals. A gene called LmjPES, similar to the human oncogene PES1, plays a role in cell processes and showed increased infection rates when overexpressed in parasites. Mice infected with parasites overexpressing LmjPES had higher inflammation levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Diksha Kumari, Kuljit Singh
Summary: Leishmaniasis, a neglected tropical disease caused by different species of Leishmania parasite, still poses a global concern. This review focuses on the immunological perspectives of the disease, discussing the role of host immune cells in countering parasite infection and highlighting recent discoveries in leishmanicidal molecules/compounds. The knowledge gained from this review can contribute to the identification of biomarkers, novel therapeutics, and vaccine candidates against leishmaniasis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Infectious Diseases
Parna Bhattacharya, Nevien Ismail, Ankit Saxena, Sreenivas Gannavaram, Ranadhir Dey, Timur Oljuskin, Adovi Akue, Kazuyo Takeda, James Yu, Subir Karmakar, Pradeep K. Dagur, John Philip McCoy, Hira L. Nakhasi
Summary: This study evaluated the interactions between neutrophils and DCs during infection with different Leishmania parasites and found that DCs that engulf LdCen(-/-) infected neutrophils exhibit a more proinflammatory phenotype and are more effective in priming CD4(+)T cells, contributing to shaping the immune response induced by a live attenuated Leishmania vaccine.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Microbiology
Raquel Garcia-Hernandez, Ana Perea-Martinez, Jose Ignacio Manzano, Laura C. Terron-Camero, Eduardo Andres-Leon, Francisco Gamarro
Summary: Leishmaniasis, a neglected tropical disease, lacks an effective vaccine and drug resistance as well as therapeutic failure are major challenges for treatment. This study found significant changes in gene expression in Leishmania parasites isolated from patients with therapeutic failure. These changes may improve the survival of the parasites in host cells, contributing to therapeutic failure.
Article
Microbiology
Hasnaa Maksouri, Dounia Darif, Jerome Estaquier, Myriam Riyad, Christophe Desterke, Meryem Lemrani, Pham My-Chan Dang, Khadija Akarid
Summary: This study evaluated the impact of Moroccan strains of L. major and L. tropica on PMNs. The results showed that L. tropica inhibited O-2(-) production, while L. major did not. Additionally, Leishmania soluble antigens from both species inhibited O-2(-) induction.
Review
Immunology
Taina Cavalcante, Mariana Medina Medeiros, Simon Ngao Mule, Giuseppe Palmisano, Beatriz Simonsen Stolf
Summary: Sialic acids (Sias) play important roles in cell communication, infection, and survival of pathogens on the cell surface. More than 20 pathogens can incorporate Sias from hosts to enhance survival inside the host, especially evident in Leishmania infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Giovanni Bussotti, Blaise Li, Pascale Pescher, Barbora Vojtkova, Isabelle Louradour, Katerina Pruzinova, Jovana Sadlova, Petr Volf, Gerald F. Spath
Summary: This study investigates the genomic adaptation of the parasitic pathogen Leishmania donovani during sand fly infection. The findings suggest that oxidative DNA damage and DNA repair processes contribute to haplotype and allelic selection in the parasite.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
E. Gaffney, D. Murphy, A. Walsh, S. Connolly, S. A. Basdeo, J. Keane, J. J. Phelan
Summary: Neutrophils play a crucial role in the pathogenesis of inflammatory diseases and the innate immune response, but their ability to combat Mycobacterium tuberculosis in the lung is still uncertain. Understanding the role of neutrophils in the infected lung can help in designing immunomodulatory therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Atish Nag, Kumarjeet Banerjee, Ranajit Barman, Joy Kar, Debi P. Sarkar, Siddhartha Sankar Jana, Suhrit Ghosh
Summary: A polymer with pendant sulfate groups and a flexible hydrocarbon backbone exhibits folding and assembly through intrachain H-bonding, producing an anionic polymersome. It displays efficient antiviral activity against Sendai virus by inhibiting its entry to the cells. The fusion-induced antiviral activity relies on the chain folding and pendant sulfate groups, providing a structural guideline for developing new antiviral polymers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Immunology
Melanie Charmoy, Benjamin P. Hurrell, Audrey Romano, Sang Hun Lee, Flavia Ribeiro-Gomes, Nicolas Riteau, Katrin Mayer-Barber, Fabienne Tacchini-Cottier, David L. Sacks
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)
Article
Immunology
Alina Zamoshnikova, Christina J. Gross, Steffen Schuster, Kaiwen W. Chen, Anne Wilson, Fabienne Tacchini-Cottier, Kate Schroder
Article
Cell Biology
Benjamin P. Hurrell, Manon Beaumann, Sandrina Heyde, Ivo B. Regli, Andreas J. Mueller, Fabienne Tacchini-Cottier
JOURNAL OF LEUKOCYTE BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Vitul Jain, Manickam Yogavel, Haruhisa Kikuchi, Yoshiteru Oshima, Norimitsu Hariguchi, Makoto Matsumoto, Preeti Goel, Bastien Touquet, Rajiv S. Jumani, Fabienne Tacchini-Cottier, Karl Harlos, Christopher D. Huston, Mohamed-Ali Hakimi, Amit Sharma
Article
Immunology
Marc Descatoire, Benjamin P. Hurrell, Melissa Govender, Katiuska Passelli, Berenice Martinez-Salazar, Ramona Hurdayal, Frank Brombacher, Reto Guler, Fabienne Tacchini-Cottier
FRONTIERS IN IMMUNOLOGY
(2017)
Review
Immunology
Ivo B. Regli, Katiuska Passelli, Benjamin P. Hurrell, Fabienne Tacchini-Cottier
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Guy Caljon, Dorien Mabille, Benoit Stijlemans, Carl De Trez, Massimiliano Mazzone, Fabienne Tacchini-Cottier, Marie Malissen, Jo A. Van Ginderachter, Stefan Magez, Patrick De Baetselier, Jan Van den Abbeele
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Melissa Govender, Ramona Hurdayal, Berenice Martinez-Salazar, Kaya Gqada, Shandre Pillay, Lorna Gcanga, Katiuska Passelli, Natalie E. Nieuwenhuizen, Fabienne Tacchini-Cottier, Reto Guler, Frank Brombacher
INFECTION AND IMMUNITY
(2018)
Article
Dermatology
Catherine Ronet, Katiuska Passelli, Melanie Charmoy, Leo Scarpellino, Elmarie Myburgh, Yazmin Hauyon La Torre, Salvatore Turco, Jeremy C. Mottram, Nicolas Fasel, Sanjiv A. Luther, Stephen M. Beverley, Pascal Launois, Fabienne Tacchini-Cottier
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Immunology
Ivo B. Regli, Olga Lucia Fernandez, Berenice Martinez-Salazar, Maria Adelaida Gomez, Nancy Gore Saravia, Fabienne Tacchini-Cottier
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Sang Hun Lee, Mariana M. Chaves, Olena Kamenyeva, Pedro H. Gazzinelli-Guimaraes, Byunghyun Kang, Gabriela Pessenda, Katiuska Passelli, Fabienne Tacchini-Cottier, Juraj Kabat, Elizabeth A. Jacobsen, Thomas B. Nutman, David L. Sacks
SCIENCE IMMUNOLOGY
(2020)
Article
Microbiology
Berenice Martinez-Salazar, Vanessa Carregaro Pereira, Yazmin Hauyon-La-Torre, Ali Khamesipour, Fabienne Tacchini-Cottier
Article
Multidisciplinary Sciences
Kaiwen W. Chen, Benjamin Demarco, Saray Ramos, Rosalie Heilig, Michiel Goris, James P. Grayczyk, Charles-Antoine Assenmacher, Enrico Radaelli, Leonel D. Joannas, Jorge Henao-Mejia, Fabienne Tacchini-Cottier, Igor E. Brodsky, Petr Broz
Summary: Injection of effector proteins by pathogenic organisms to block host innate immune signaling is a common strategy for establishing infection. This study reveals that GSDME is activated in a RIPK1-dependent manner and promotes neutrophil pyroptosis and IL-113 release critical for anti-Yersinia defense, establishing it as an important mediator to counteract pathogen blockade of innate immune signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Katiuska Passelli, Borja Prat-Luri, Margot Merlot, Michiel Goris, Massimiliano Mazzone, Fabienne Tacchini-Cottier
Summary: This study investigates the role of c-MET receptor tyrosine kinase in the pathology of leishmaniasis. The results show that L. mexicana infection induces the expression and phosphorylation of c-MET in neutrophils. Genetic deficiency of c-MET in neutrophils leads to better control of lesion size and parasite load. In addition, inhibition of c-MET with a specific inhibitor significantly reduces the cutaneous pathology. These findings suggest that c-MET contributes to the development of cutaneous lesions in leishmaniasis, and targeting c-MET may have potential therapeutic value.
Article
Cell Biology
Borja Prat-Luri, Christopher Neal, Katiuska Passelli, Emma Ganga, Jonas Amore, Luan Firmino-Cruz, Tatiana Petrova, Andreas J. Mueller, Fabienne Tacchini-Cottier
Summary: Neutrophils transiently migrate to draining lymph nodes through blood vessels via the C5a-C5aR1 axis, guided by L-selectin and integrins, according to a study using a murine model of dermal infection. The study also found that C5, the C5a precursor, is locally produced in the draining lymph node by lymphatic endothelial cells.