Article
Ophthalmology
Jihei Sara Lee, Hyoung Won Bae, Sungeun Park, Chan Yun Kim, Sang Yeop Lee
Summary: The study aimed to determine the association between arterial stiffness predicted by brachial-ankle pulse wave velocity (PWV) and structural progression in early open-angle glaucoma. The results showed that high PWV was associated with macular ganglion cell-inner plexiform layer (mGCIPL) loss preceding peripapillary retinal nerve fiber layer (ppRNFL) loss.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Mitchell Kirby, Peijun Tang, Hong-Cin Liou, Maju Kuriakose, John J. Pitre, Tam N. Pham, Russell Ettinger, Ruikang Wang, Matthew O'Donnell, Ivan Pelivanov
Summary: This study reports a non-contact and non-invasive method to image and characterize the elastic anisotropy of the skin. Through acoustic micro-tapping optical coherence elastography and a nearly incompressible transversely isotropic model, the elastic moduli of the skin can be quantitatively analyzed. The results demonstrate the elastic anisotropy of the skin in all subjects. This method has the advantages of objective and quantitative characterization without contact, and has potential for broad clinical use.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Michael G. Sun, Taeyoon Son, Joseph Crutison, Victor Guaiquil, Shujun Lin, Lara Nammari, Dieter Klatt, Xincheng Yao, Mark I. Rosenblatt, Thomas J. Royston
Summary: The cornea is a highly specialized organ that requires mechanical stiffness to maintain its shape and refractive power. Dynamic optical coherence elastography is a non-contact imaging technique that can be used to measure corneal tissue stiffness. However, the effects of intraocular pressure-induced prestress must be taken into consideration for accurate measurements.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Physics, Multidisciplinary
Justin R. Rippy, Manmohan Singh, Achuth Nair, Salavat Aglyamov, Kirill V. Larin
Summary: This study aims to merge quantitative compression elastography and qualitative compressive strain elastography by implementing an uncalibrated stress sensor for calculating Young's modulus. The results show that quantitative compression elastography can accurately measure the Young's modulus values in gelatin and tissue samples.
FRONTIERS IN PHYSICS
(2022)
Article
Biochemical Research Methods
Achuth Nair, Manmohan Singh, Salavat Aglyamov, Kirill Larin
Summary: This study demonstrates that heartbeat optical coherence elastography can assess the mechanical properties of the cornea in vivo without external excitation, by detecting Hb-induced deformations and distinguishing corneal stiffness between untreated and crosslinked tissue.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Article
Optics
Qingrui Li, Tianduo Lai, Zhenyang Ding, Kuiyuan Tao, Fengyu Zhu, Hao Kuang, Peidong Hua, Yin Yu, Tiegen Liu
Summary: This paper compares polarization imaging methods based on Jones matrix and Mueller matrix, finding that Mueller matrix performs better in handling non-coaxial diattenuation. Experimental results show that Mueller matrix with incoherent averaging method has better performance in areas with low signal to noise ratio.
OPTICS AND LASER TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Gongpu Lan, Qun Shi, Yicheng Wang, Guoqin Ma, Jing Cai, Jinping Feng, Yanping Huang, Boyu Gu, Lin An, Jingjiang Xu, Jia Qin, Michael D. Twa
Summary: This study analyzed the natural frequency of corneal tissue using optical coherence tomography-based elastography. The results showed that the natural frequency can reveal local variations in tissue structure and can differentiate different types of tissues. This method could provide additional information on corneal properties and be a useful tool for clinical detection of ocular disease and evaluation of treatment outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Acoustics
Laura Daniela Ordierez Zuniga, Carlos Alberto Gaviria Lopez, Elizabeth Roldan Gonzalez
Summary: The study reviews the use of ultrasound elastography techniques for evaluating muscle stiffness caused by spasticity in patients with central nervous system diseases. While showing some limitations in spasticity assessment, the technique holds promise as a diagnostic tool for designing treatment plans and monitoring treatment effectiveness.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Engineering, Biomedical
Sarah Latus, Sarah Grube, Tim Eixmann, Maximilian Neidhardt, Stefan Gerlach, Robin Mieling, Gereon Huettmann, Matthias Lutz, Alexander Schlaefer
Summary: This study introduces a robust approach for elasticity quantification from within the tissue using a miniaturized dual-fiber OCE probe. The results demonstrate the feasibility of quantifying local tissue elasticities and the improved robustness in inhomogeneous tissues. In addition, the study shows the potential of applying this method to ex-vivo coronary arteries.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Review
Biochemical Research Methods
Chongyang Wang, Jiang Zhu, Jiawei Ma, Xiaochen Meng, Zongqing Ma, Fan Fan
Summary: The biomechanical characterization of tissues is important for determining pathological status and assessing disease treatment. Optical coherence elastography (OCE) is a high-resolution imaging technique that can map the spatial elasticity distribution of biological tissue. This article reviews OCE methods and summarizes its current applications in biomedicine.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Foucauld Chamming's, Chloe Hangard, Jean-Luc Gennisson, Caroline Reinhold, Laure S. Fournier
Summary: This study investigates the diagnostic accuracy of applying four levels of manual pressure in Shear Wave Elastography (SWE) of the breast and assesses inter-rater reliability. Results suggest that the application of compression leads to higher diagnostic performance with good interobserver agreement.
ACADEMIC RADIOLOGY
(2021)
Article
Optics
Arkadev Roy, Rajveer Nehra, Saman Jahani, Luis Ledezma, Carsten Langrock, Martin Fejer, Alireza Marandi
Summary: In this study, dissipative quadratic soliton formation is achieved through non-stationary optical parametric amplification, accompanied by half-harmonic generation and substantial pulse compression. The method is suitable for low-finesse cavities at low pump pulse energies.
Article
Multidisciplinary Sciences
Maximilian Neidhardt, Robin Mieling, Marcel Bengs, Alexander Schlaefer
Summary: Robotic assistance in minimally invasive surgery has advantages but lacks force feedback, making accurate tool-tissue interaction force estimation a challenge. Image-based force estimation, using observed deformation and learning methods, offers a promising solution. In this work, optical coherence tomography is used to combine tissue deformation detection with shear wave elastography for accurate force estimation. A multi-input deep learning network processing local elasticity estimates and volumetric image data yields the best performance. The approach also shows generalization to other tissue properties.
SCIENTIFIC REPORTS
(2023)
Article
Optics
Yubao Zhang, Jiahui Luo, Xiao Han, Gang Shi, Qin Zhang, Xingdao He
Summary: This study developed and applied a shaker-based optical coherence elastography technique for non-destructive detection of tongue elasticity. The technique showed high resolution and sensitivity, making it potentially valuable in clinical applications.
Article
Biochemical Research Methods
Vladimir Y. Zaitsev, Alexander A. Sovetsky, Alexander L. Matveyev, Lev A. Matveev, Dmitry Shabanov, Victoria Y. Salamatova, Pavel A. Karavaikin, Yuri V. Vassilevski
Summary: Compression Optical Coherence Elastography (C-OCE) has made impressive progress in diverse biomedical applications, particularly in nondestructive characterization of human pericardium biomechanics. This technique allows spatially resolved characterization of elasticity in thin samples and provides nonlinear stress-strain data, which is valuable for aortic valve replacement in cardio-surgery.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Ophthalmology
Philip j. Rosenfeld, O. M. E. R. Trivizki, G. I. O. V. A. N. N. I. Gregori, Ruikang k. Wang
Summary: This article provides an update on the hemodynamic model of age-related macular degeneration (AMD). The results suggest that choroidal perfusion is an important environmental influence that contributes to disease progression in AMD. Genetic susceptibility and age-related changes in choroidal circulation play a significant role in AMD development.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Nicholas T. Rinella, Hao Zhou, Jessica Wong, Qinqin Zhang, Khashayar Nattagh, Travis C. Porco, Ruikang K. Wang, Daniel M. Schwartz, Jacque L. Duncan
Summary: This study found that choriocapillaris flow deficit significantly increased in patients with geographic atrophy, while retinal sensitivity significantly decreased. An inverse correlation was observed between choriocapillaris flow deficit and sensitivity.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Grace M. Richter, Jae Chang Lee, Nasir Khan, Alexander Vorperian, Brennan Hand, Bruce Burkemper, Xiao Zhou, Zhongdi Chu, Ruikang Wang, Rohit Varma, Amir H. Kashani
Summary: This study aimed to investigate the relationship between systemic and ocular characteristics and perifoveal and macular vessel density in healthy African American eyes. The results showed that longer axial length, reduced signal strength, reduced central subfield thickness, and older age were independently associated with reduced perifoveal and macular vessel density.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Woo June Choi, Yuandong Li, Ruikang K. Wang, Jun Ki Kim
Summary: This paper proposes a method using OCT for counting penetrating blood vessels, which can effectively identify and count cortical penetrating vessels with an accuracy of over 87%. The study also observed a significant reduction in penetrating vessel density in a mouse model of focal ischemic stroke.
Article
Optics
Qinghua He, Ruikang K. Wang
Summary: We present a method for imaging facial cutaneous microvascular perfusion using wide-field imaging photoplethysmography (iPPG) and handheld swept-source optical coherence tomography (OCT). The iPPG system utilizes a 16-bit-depth camera to generate a 2D wide-field blood pulsation map for guiding the OCT imaging of cutaneous microvasculature. The results from iPPG and OCT demonstrate the potential of guided imaging of cutaneous microvasculature for assessing skin conditions in dermatology and cosmetology.
Article
Optics
Zhaoyu Gong, Yaping Shi, Ruikang K. Wang
Summary: We demonstrate a dual under-sampling method for de-aliased and depth-range-extended optical coherence tomography imaging. By changing the sampling frequency, the true image can be distinguished from aliasing artifacts, resulting in a significant reduction in data size while accurately measuring the true depth.
Article
Ophthalmology
Jonathan F. Russell, Hao Zhou, Yingying Shi, Mengxi Shen, Giovanni Gregori, William J. Feuer, Ruikang K. Wang, Philip J. Rosenfeld
Summary: Widefield swept-source OCT imaging was used to study the choroidal thickness and vascularity in patients with proliferative diabetic retinopathy (PDR) before and after panretinal photocoagulation (PRP). The results showed that PDR eyes have a smaller choroidal vascularity index (CVI) compared to normal eyes. After PRP, the choroidal thickness decreases outside the fovea, but the CVI remains constant.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Paul. S. Micevych, Jessica Wong, Hao Zhou, Ruikan. K. Wang, Travis. C. Porco, Joseph Carroll, Austin Roorda, Jacque. L. Duncan
Summary: This study compared cone structure and function between patients with RPGR and USH2A-related retinal degeneration. It found that outer retinal structure and choriocapillaris perfusion were more abnormal in patients with RPGR-related retinal degeneration compared to those with USH2A-related retinal degeneration. However, there were no significant differences in below-normal regional sensitivity between rod-cone degeneration associated with variants in these 2 genes expressed at the photoreceptor-connecting cilium.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Clinical Neurology
Wenbin Zhu, Catherine M. M. Davis, Elyse M. M. Allen, Sarah L. L. Feller, Thierno M. M. Bah, Robert E. E. Shangraw, Ruikang K. K. Wang, Nabil J. J. Alkayed
Summary: In this study, the researchers found that poor outcome after stroke in patients with type 2 diabetes (DM2) is linked to impaired microvascular tissue reperfusion. Furthermore, they discovered differences in microvascular reperfusion response between male and female DM2 mice after transient middle cerebral artery occlusion (MCAO). These findings suggest that DM2 impairs capillary perfusion and exacerbates ischemic brain injury in male but not female mice with DM2.
Editorial Material
Biochemical Research Methods
Ruikang K. Wang, Sina Farsiu
Summary: The Editor-in-Chief and Deputy Editor of Biomedical Optics Express have introduced a new prize to honor the best paper published in the Journal between 2019 and 2021.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemical Research Methods
Qinghua He, Wanyu Li, Yaping Shi, Yi Yu, Wenqian Geng, Zhiyuan Sun, Ruikang K. Wang
Summary: SpeCamX is a mobile application that transforms a regular smartphone into a multispectral imager. It utilizes the smartphone's RGB photographs and converts them into multispectral images, eliminating the need for specialized devices or attachments. The app also includes plugin functions for extracting medical information. In a clinical study, SpeCamX was used to create an augmented smartphone bilirubinometer with superior performance compared to default smartphone cameras.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemical Research Methods
Philip J. Rosenfeld, Yuxuan Cheng, Mengxi Shen, Giovanni Gregori, Ruikang K. Wang
Summary: The use of optical attenuation coefficients in OCT imaging has improved the segmentation of anatomical layers and allows for better measurement of choroidal indicators. It also enables the detection of factors associated with disease progression.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemical Research Methods
Qinghua He, Wenqian Geng, Wanyu Li, Ruikang k. Wang
Summary: This study presents a method and system for non-contact measurement of neck pulses using micro-motion imaging (mu MI). The proposed method extracts carotid pulse (CP) and jugular vein pulse (JVP) waveforms without the need for manual identification, making it non-invasive and self-guided. The experimental results demonstrate the feasibility of the method and its potential use in early screening of cardiovascular diseases.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Ophthalmology
Sam Kushner-Lenhoff, Yuandong Li, Qinqin Zhang, Ruikang K. Wang, Xuejuan Jiang, Amir H. Kashani
Summary: This study examines the relationship between retinal capillary flux measured by optical coherence tomography angiography (OCTA) and systemic determinants of health. The results suggest that retinal capillary perfusion, as indicated by flux and vessel skeleton density (VSD), is associated with various systemic factors, such as age, blood pressure, diabetes status, and hematocrit. The findings highlight the potential of OCTA-derived measures to provide additional information about retinal perfusion and its relationship with overall health.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Medicine, General & Internal
S. Lee, R. K. Wang
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)