期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 19, 期 10, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.19.10.106007
关键词
polarization; Mueller matrix; Monte Carlo simulation; orientation angle; cancerous tissues
资金
- National Natural Science Foundation of China [11174178, 11374179, 61205199]
- Knowledge Innovation Program of Basic Research Projects of Shenzhen [JCY20130402145002404]
Polarization measurements are sensitive to the microstructure of tissues and can be used to detect pathological changes. Many tissues contain anisotropic fibrous structures. We obtain the local orientation of aligned fibrous scatterers using different groups of the backscattering Mueller matrix elements. Experiments on concentrically well-aligned silk fibers and unstained human papillary thyroid carcinoma tissues show that the m22, m33, m23, and m32 elements have better contrast but higher degeneracy for the extraction of orientation angles. The m12 and m13 elements show lower contrast, but allow us to determine the orientation angle for the fibrous scatterers along all directions. Moreover, Monte Carlo simulations based on the sphere-cylinder scattering model indicate that the oblique incidence of the illumination beam introduces some errors in the orientation angles obtained by both methods. Mapping the local orientation of anisotropic tissues may not only provide information on pathological changes, but can also give new leads to reduce the orientation dependence of polarization measurements. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
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