Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Nan Yi, Hailiang Zhao, Juan He, Xike Xie, Liexin Liang, Guowen Zuo, Mingyue Xiong, Yunxiao Liang, Tingzhuang Yi
Summary: Almost 50% of esophageal adenocarcinoma (EAC) patients are progressed from Barrett's esophagus (BE). However, effective stratification and therapy methods for BE and EAC are still lacking. Differentially expressed genes (DEGs) between BE and EAC were identified through the analysis of two public datasets (GSE26886 and GSE37200), followed by bioinformatics analyses to explore potential biomarkers associated with BE-EAC. The results revealed a number of up- and down-regulated genes, which were highly involved in tumorigenesis according to the GO and KEGG enrichment analysis. In addition, the study identified several potential diagnostic and prognostic biomarkers in BE-EAC.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Elissa M. Ozanne, Elisabeth R. Silver, Sameer D. Saini, Joel H. Rubenstein, Iris Lansdorp-Vogelaar, Nicole Bowers, Sarah Xinhui Tan, John M. Inadomi, Chin Hur
Summary: Physicians' recommendations for BE surveillance cessation vary based on patient age, comorbidities, and BE length, with age showing the most significant variation in decisions. It appears that age and comorbidities influence BE surveillance cessation decisions, but with differences among clinicians. Clear guidelines balancing the risks and benefits of BE surveillance cessation are needed.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Franz Ludwig Dumoulin, Fabian Dario Rodriguez-Monaco, Alanna Ebigbo, Ingo Steinbruck
Summary: Esophageal adenocarcinoma is the most common subtype of esophageal cancer in Western societies and its incidence is increasing. The development and validation of artificial intelligence systems in the field of gastroenterology may help address unresolved issues in the prevention and surveillance of this cancer.
Review
Gastroenterology & Hepatology
Motasem Alkhayyat, Prabhat Kumar, Krishna O. Sanaka, Prashanthi N. Thota
Summary: The incidence of Barrett's esophagus and esophageal adenocarcinoma has been increasing, leading to a search for chemoprevention strategies. Proton-pump inhibitors and Aspirin have shown effectiveness in reducing cancer incidence in Barrett's patients. Other agents lack sufficient evidence for chemoprevention in these patients.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Chunyang Bao, Richard W. Tourdot, Gregory J. Brunette, Chip Stewart, Lili Sun, Hideo Baba, Masayuki Watanabe, Agoston T. Agoston, Kunal Jajoo, Jon M. Davison, Katie S. Nason, Gad Getz, Kenneth K. Wang, Yu Imamura, Robert Odze, Adam J. Bass, Matthew D. Stachler, Cheng-Zhong Zhang
Summary: By analyzing chromosomal copy-number evolution in early cancers and precancerous lesions of the esophagus, the authors reveal signatures of ongoing chromosomal instability and its role in promoting tumor progression.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Lei Chen, Farah Ballout, Heng Lu, Tianling Hu, Shoumin Zhu, Zheng Chen, Dunfa Peng
Summary: In this study, the gene expression of NEK family members in esophageal adenocarcinoma and its precancerous condition was analyzed. The findings suggest that upregulation of certain NEKs may be important in the development of esophageal adenocarcinoma.
Article
Oncology
Anshuman Panda, Gyan Bhanot, Shridar Ganesan, Manisha Bajpai
Summary: Stable cell lines derived from primary tissues and tumors are commonly used in medical research. This study evaluated gene expression profiles of esophageal tissues and cell lines, finding discrepancies in the gene expression profiles of Barrett's esophagus (BE) cell lines compared to primary BE tissues and esophageal adenocarcinoma (EAC) tumors. Exposure to an acidic bile environment did not alter the squamous-like gene expression pattern of a BE cell line. The findings underscore the importance of carefully selecting appropriate in vitro tools for studying esophageal adenocarcinoma.
Article
Gastroenterology & Hepatology
Edward H. Tsoi, Puneet Mahindra, Georgina Cameron, Richard Williams, Richard Norris, Paul Desmond, Spiro Raftopoulos, Darren Pavey, Arti Rattan, Luke F. Hourigan, Richard Lee, Michael J. Bourke, Naaz Sidhu, Rajvinder Singh, Andrew Chan, Sudarshan Krishnamurthi, Andrew C. F. Taylor
Summary: This study aimed to determine the proportion of prevalent HGD or EAC detected in Barrett's esophagus (BE) patients referred from the community with a recent diagnosis of low-grade dysplasia (LGD). The results showed that BERU assessment endoscopy identified more visible lesions than community referral endoscopy and identified HGD or EAC in 27% of patients referred from the community with a recent diagnosis of LGD. Reported progression rates from LGD to HGD or EAC may be overestimated.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Medicine, General & Internal
Kazumi Inokuchi, Takahiro Ochiya, Juntaro Matsuzaki
Summary: Esophageal adenocarcinoma (EAC) is the major histologic type of esophageal cancer in Western countries with a poor prognosis primarily due to late stage diagnosis. Barrett's esophagus (BE) is a precursor lesion of EAC. Extracellular microRNAs (miRNAs) may serve as non-invasive markers for the management of EAC in the future, with potential utility for diagnosis and treatment responses. Multiple studies have reported dysregulation of certain miRNAs in both EAC and BE, suggesting their potential as valuable biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Takuya Shijimaya, Tomomitsu Tahara, Jumpei Yamazaki, Yasushi Matsumoto, Naohiro Nakamura, Yu Takahashi, Takashi Tomiyama, Toshiro Fukui, Tomoyuki Shibata, Makoto Naganuma
Summary: The molecular mechanisms of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) in Japanese patients are still unclear. A study conducted on Japanese patients, mostly with short-segment BE (SSBE), found that methylation levels of the N33, DPYS, and SLC16A12 genes were higher in the ADJ and T groups compared to the N group.
MOLECULAR CARCINOGENESIS
(2023)
Article
Immunology
Cathryn M. Kolka, Julie Webster, Ailin Lepletier, Clay Winterford, Ian Brown, Renee S. Richards, Wioleta M. Zelek, Yilang Cao, Ramlah Khamis, Karthik B. Shanmugasundaram, Alain Wuethrich, Matt Trau, Sandra Brosda, Andrew Barbour, Alok K. Shah, Guy D. Eslick, Nicholas J. Clemons, B. Paul Morgan, Michelle M. Hill
Summary: This study confirms the increased formation of C5b-9 in esophageal adenocarcinoma (EAC) and demonstrates the capability and heterogeneity in C5b-9 formation and shedding in Barrett's Esophagus (BE) and EAC cell lines following sublytic C9 exposure.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Jitka Vaculova, Radek Kroupa, Zdenek Kala, Jiri Dolina, Tomas Grolich, Jakub Vlazny, David Said, Lydie Izakovicova Holla, Petra Borilova Linhartova, Vladimir Prochazka, Marek Joukal, Petr Jabandziev, Ondrej Slaby, Lumir Kunovsky
Summary: Confocal laser endomicroscopy (CLE) is a real-time microscopic imaging technique used mainly in gastroenterology, particularly in the diagnosis of Barrett's esophagus and esophageal adenocarcinoma. Although many studies have shown that CLE increases diagnostic accuracy in detecting neoplastic transformation of BE, it is still not widely used as a standard diagnostic tool in BE surveillance due to a lack of scientific evidence.
Article
Dentistry, Oral Surgery & Medicine
Martin Prager, Mark Pierce, Pablo J. Atria, Camila Sampaio, Eduardo Caceres, Mark Wolff, Marcelo Giannini, Ronaldo Hirata
DENTAL MATERIALS JOURNAL
(2018)
Article
Biochemical Research Methods
Laura M. Higgins, Vidya Ganapathy, Harini Kantamneni, Xinyu Zhao, Yang Sheng, Mei-Chee Tan, Charles M. Roth, Richard E. Riman, Prabhas V. Moghe, Mark C. Pierce
JOURNAL OF BIOMEDICAL OPTICS
(2018)
Review
Dentistry, Oral Surgery & Medicine
Christine C. Sahyoun, Hrebesh M. Subhash, Deborah Peru, Roger P. Ellwood, Mark C. Pierce
Article
Optics
John P. Dumas, Muhammad A. Lodhi, Batoul A. Taki, Waheed U. Bajwa, Mark C. Pierce
Article
Multidisciplinary Sciences
Megan Heenan, Jose D. Rojas, Z. Maria Oden, Rebecca Richards-Kortum
Article
Chemistry, Analytical
Mary E. Natoli, Megan M. Chang, Kathryn A. Kundrod, Jackson B. Coole, Gladstone E. Airewele, Venee N. Tubman, Rebecca R. Richards-Kortum
Summary: A rapid and low-cost nucleic acid test for detecting the point mutation in SCD has been developed in this study, showing high sensitivity and specificity with a turnaround time of less than 30 minutes. The test can be performed near the point of care and may be adapted for detecting other disease-causing point mutations in genomic DNA.
ANALYTICAL CHEMISTRY
(2021)
Editorial Material
Chemistry, Multidisciplinary
Emilie Newsham, Rebecca Richards-Kortum
ACS CENTRAL SCIENCE
(2021)
Article
Engineering, Biomedical
Catherine E. Majors, Michal E. Pawlowski, Tomasz S. Tkaczyk, Queen Dube, Rebecca Richards-Kortum
Summary: The study demonstrates that LeukoScope can assist in measuring WBC counts in pediatric patients but faces challenges in accurately assessing WBC counts in neonatal patients.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Pediatrics
Jennifer Carns, Sara Liaghati-Mobarhan, Aba Asibon, Alfred Chalira, Norman Lufesi, Elizabeth Molyneux, Maria Z. Oden, Rebecca Richards-Kortum, Kondwani Kawaza
Summary: The study revealed a significant improvement in survival rates for neonates weighing 1.0-1.3 kg after the implementation of CPAP in Malawi government hospitals, with the improvement sustained during the follow-up period. This demonstrates the effectiveness of a nurse-led CPAP program in improving outcomes for this neonatal population.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Engineering, Biomedical
Jesse K. Adams, Dong Yan, Jimin Wu, Vivek Boominathan, Sibo Gao, Alex Rodriguez, Soonyoung Kim, Jennifer Carns, Rebecca Richards-Kortum, Caleb Kemere, Ashok Veeraraghavan, Jacob T. Robinson
Summary: Lensless microscopy with a designed phase mask allows for imaging of biological tissue in vivo, overcoming the limitations of existing techniques. The low-cost and small form factor of this lensless imaging method makes it suitable for clinical use in inaccessible areas of the body.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Huayu Hou, Ruchika Mitbander, Yubo Tang, Ahad Azimuddin, Jennifer Carns, Richard A. Schwarz, Rebecca R. Richards-Kortum
Summary: This article reviews the recent development and application of low-cost optical imaging technologies, emphasizing the integration of artificial intelligence to improve in vivo cancer detection accuracy in low-resource settings. The article also discusses the challenges and future prospects of applying optical imaging technologies in clinical practice.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2023)
Article
Pediatrics
Sonia E. Sosa Saenz, Mary Kate Hardy, Megan Heenan, Z. Maria Oden, Rebecca Richards-Kortum, Queen Dube, Kondwani Kawaza
BMJ PAEDIATRICS OPEN
(2020)
Article
Biochemical Research Methods
John-Paul Dumas, James Y. Jiang, Evan M. Gates, Brenton D. Hoffman, Mark C. Pierce, Nada N. Boustany
JOURNAL OF BIOMEDICAL OPTICS
(2019)
Article
Chemistry, Multidisciplinary
Catherine E. Majors, Michal E. Pawlowski, Daniel C. Burke, Tomasz S. Tkaczyk, Alyssa Rieber, Rebecca Richards-Kortum
Article
Engineering, Biomedical
Sonia Parra, Eduardo Carranza, Jackson Coole, Brady Hunt, Chelsey Smith, Pelham Keahey, Mauricio Maza, Kathleen Schmeler, Rebecca Richards-Kortum
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2020)