Article
Engineering, Biomedical
Julian F. Ashby, Julien Schmidt, K. C. Neelima, Armand Kurum, Caroline Koch, Alexandre Harari, Li Tang, Sam H. Au
Summary: This study presents a novel microfluidic approach based on fluid shear stress to identify and recover highly potent T cell clones through probing cellular avidity. The method demonstrates efficient and rapid recovery of high-purity T cells from mixed populations, and markers of cytotoxicity, activation, and avidity persist upon exposure to fresh tumor cells.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Bradley Burden, Juan Sebastian Rodriguez-Alvarez, Nicole Levi, F. Scott Gayzik
Summary: Eighty percent of bacterial infections associated with living tissue and medical devices are linked to drug-resistant biofilms. Laser-induced hyperthermia can disrupt cell proliferation within biofilms and increase susceptibility to antibiotics. Survival analysis was employed to estimate bacterial cell proliferation post-treatment to provide a quantitative framework for future studies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qingduo Kong, Dengshuai Wei, Peng Xie, Bin Wang, Kunyi Yu, Xiang Kang, Yongjun Wang
Summary: Ovarian cancer, with the highest mortality rate among gynecologic tumors, is mainly treated with platinum-based chemotherapy in advanced cases. Combining photothermal therapy with platinum drugs in a new delivery system could potentially enhance treatment efficacy. Nanoparticles containing Pt (IV) and IR1048 showed increased DNA damage and endoplasmic reticulum stress under NIR II light, suggesting a promising approach for ovarian cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Saeedeh Kabiri, Fatemeh Rezaei
Summary: This paper studies the effectiveness of integrating microwave field irradiation and laser emission in liver cancer therapy with the aid of gold nanorods. The results show that the injection of gold nanorods significantly increases the tumor necrosis rate, and the combination of microwave antenna and laser illumination can completely eradicate tumor tissue.
SCIENTIFIC REPORTS
(2022)
Review
Biotechnology & Applied Microbiology
Laura Gonzalez-Rodriguez, Sara Perez-Davila, Miriam Lopez-Alvarez, Stefano Chiussi, Julia Serra, Pio Gonzalez
Summary: This paper reviews the relevant parameters and results of in vitro and in vivo studies on near-infrared laser-induced hyperthermia using graphene oxide (GO) and reduced graphene oxide (rGO). The results show that GO and rGO are effective photothermal conversion agents for controlled hyperthermia. Evaluating the potential to use lower temperatures in each application is possible.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemical Research Methods
Elharith M. Ahmed, Gary D. Noojin, Michael L. Denton
Summary: Physics-based models provide comprehensive risk assessments for laser-induced damage by simulating temperature rises. This study aims to derive a nonisothermal form of the damage integral to accurately predict damage induced by short laser exposures and identify the role of heating rate. The study successfully derived a modified damage integral that takes nonisothermal heating into account and presents a new option for laser damage modelers.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Pharmacology & Pharmacy
Siva Sankari Sivasoorian, Ritesh Urade, Chien-Chih Chiu, Li-Fang Wang
Summary: This study synthesized a neuropeptide-functionalized gold nanorod and evaluated its cellular uptake and photothermal effects on glioma cells. The results showed that the functionalized nanorods had higher cellular uptake and induced higher rates of apoptosis and ROS production under laser irradiation. The study provides insights into the effective time point for maximum cellular uptake and potential improvements in anti-glioma therapy.
Article
Nanoscience & Nanotechnology
Geng Yang, Qingqing Su, Jiazhen Lv, Yue Zheng, Ting Song, Hanxi Zhang, Mengyue Li, Wanyi Zhou, Tingting Li, Xiang Qin, Shun Li, Chunhui Wu, Xiaoling Liao, Yiyao Liu, Hong Yang
Summary: In this study, a mussel-inspired multifunctional nanomedicine (ZS-MB@P) was designed for inhibiting tumor growth and metastasis through amplified oxidative stress and photothermal/magnetothermal/photodynamic triple-combination therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Xuefeng He, Rong Chen, Xun Zhu, Qiang Liao, Shuzhe Li
Summary: This study demonstrates localized fluid manipulation in microchannels using infrared laser-induced phase change process, investigating dynamic behaviors and effects of laser power, spot speed, and channel structure. Results show that actuation speed can be tuned by laser power, and flow direction can be controlled by laser spot trajectory. Long distance actuation performance is affected by fluid volume and flow resistance, providing efficient fluid manipulation in microfluidic channels for various applications.
MICROFLUIDICS AND NANOFLUIDICS
(2021)
Article
Chemistry, Multidisciplinary
Penghao Ji, Shenyan Zhang, Peilei Liu, Xi Li, Weichao Bao, Xiangzhi Cui, Minfeng Huo, Jianlin Shi
Summary: Programmed cell death (PCD) plays a crucial role in combating tumors in the field of biomedicine. However, malignant tumor cells often develop resistance to commonly used anticancer drugs. A newly designed nanoassembly OA@IR820 targets mitochondria and releases ATP synthase inhibitor OA, leading to ATP synthesis inhibition and mitochondrial dysfunction, thereby promoting oxidative stress-mediated pyroptosis and offering a potential therapeutic strategy for malignant tumor treatment.
Article
Cell Biology
Ana Mesquita, James Glenn, Andreas Jenny
Summary: Autophagy is a major catabolic pathway crucial for cellular homeostasis and stress response. Endosomal microautophagy can be induced under stress conditions and regulated by various signaling pathways, suggesting its important role in disease prevention.
Article
Materials Science, Multidisciplinary
Michaela Welch, Deborah A. Flusberg, Peter Hsi, Nerses J. Haroutunian, Jose A. Santos, Ernest S. Kim, Stacey Markovic, Jonathan R. Coppeta, Charles A. Lissandrello, Jenna L. Balestrini, Vishal Tandon
Summary: Autologous cellular therapies have shown great success in treating hematological cancers and have potential for various indications. However, manufacturing these therapies at a rapid pace and low cost remains challenging, especially due to the genetic modification of target cells using expensive viral vectors. This study presents a microfluidic continuous-flow electroporation device that offers high throughput processing, high performance, and potential for automation, making it suitable for large-scale clinical manufacturing.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Inorganic & Nuclear
Imran Ali, Jun Chen, Saeed Ahmed Khan, Yasir Jamil, Aqeel Ahmed Shah, Abdul Karim Shah, Sadaf Jamal Gilani, May Nasser Bin Jumah, Yusra Fazal, Yunxiang Pan, Zhonghua Shen
Summary: Magneto-plasmonic Ag/Ni and Ag/Fe nanoparticles were synthesized using a dual-pulsed Q-switched Nd:YAG 1064 nm laser ablation method. The optical and magnetic properties were investigated, and the morphologies and phase structures of the nanoparticles were characterized. The synthesized nanoparticles exhibited plasmonic hyperthermia properties, reaching high temperatures when irradiated with a NIR 808 nm laser. These findings suggest the potential use of silver-based plasmonic nanoparticles for hyperthermia treatment.
Article
Mechanics
Chuyang Luo, Shuai Wang, Weidong Li, Liying Zhang, Lijian Pan
Summary: This study investigates the tensile properties of composite T-joints after laser ablation. The results of the ablation test show that the area of ablation pits and heat affected zones decrease, while the ablation depth and mass loss rate increase as the spot diameter decreases. Coarse and fine cracks are observed around the ablation zone, which significantly impact the tensile strength and failure mode of the T-joints. Tensile test results indicate a dramatic decrease in failure load after laser ablation with decreasing spot diameter.
COMPOSITE STRUCTURES
(2022)
Review
Biochemistry & Molecular Biology
Jac A. Nickoloff, Aruna S. Jaiswal, Neelam Sharma, Elizabeth A. Williamson, Manh T. Tran, Dominic Arris, Ming Yang, Robert Hromas
Summary: Replicative DNA polymerases are obstructed by various DNA damage, leading to DNA replication stress that threatens genome stability. Cellular responses to replication stress include cell cycle arrest, replication fork collapse, DNA repair induction, and programmed cell death. Nucleases play critical roles in these responses, promoting repair and restart of stressed replication forks. Understanding biological responses to genome-wide replication stress can inform novel cancer treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)