Article
Biophysics
Smruta Koppaka, Allison Hess-Dunning, Dustin J. Tyler
Summary: This study compared the biomechanical properties of different tissues in nerves, including the Young's moduli and ultimate strains of the epineurium and perineurium. The forces required to insert into each tissue were measured, providing guidance for material selection for long-term implants. These results will help guide neural interface design.
JOURNAL OF BIOMECHANICS
(2022)
Article
Physics, Applied
J. Hope, M. Goodwin, F. Vanholsbeeck
Summary: This study investigates changes in optical coherence tomography (OCT) images in response to evoked neural activity in the sciatic nerve of rats in vitro. The observed changes in OCT signal intensity and frequency spectra during neural activity suggest the potential for detecting osmotic swelling from ion currents in myelinated fibers using OCT. This imaging technique opens up new possibilities for functional imaging in the peripheral and central nervous systems.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Biochemical Research Methods
Yong-Jae Lee, Eunwoo Park, Kwan Seob Park, Jun-Hyuk Lim, Sungmin Kim, Myung-Sun Kim, Tae Joong Eom
Summary: The study developed a quantification method using PS-OCT to evaluate the fibrous structure of tendons. A rat model with partial rupture of the Achilles tendon was used, and PS-OCT and histological analysis were performed to assess the structural changes of the injured tendon. The results demonstrated the accuracy of the proposed quantification method in evaluating the fibrous structural status of tendons.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Biochemical Research Methods
Shuang Chang, Jessica Handwerker, Giovanna A. Giannico, Sam S. Chang, Audrey K. Bowden
Summary: This study introduces a method for fabricating birefringent tissue phantoms using PDMS and demonstrates its application in mimicking bladder wall layers. PDMS allows precise control of tissue scattering and thickness, and exhibits controllable birefringent properties.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Neurosciences
Damon DePaoli, Daniel C. Cote, Brett E. Bouma, Martin Villiger
Summary: PSOCT technology has been used to delineate white matter fibers, and this study demonstrates the possibility of deep imaging within intact porcine brain tissue ex-vivo, with a mobile and clinically feasible system.
Article
Biochemical Research Methods
Wai Ching Lin, Robert A. Byers, Wei Li, Simon G. Danby, Michael J. Cork, Stephen J. Matcher
Summary: Research shows a weak correlation between visual scoring of SD using a clinical visible-light dermatological camera and measuring birefringence values of skin with polarization-sensitive optical coherence tomography. The SD datasets had significantly higher birefringence values compared to visually normal datasets.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Biochemical Research Methods
Bernhard Baumann, Danielle J. Harper, Pablo Eugui, Johanna Gesperger, Antonia Lichtenegger, Conrad W. Merkle, Marco Augustin, Adelheid Woehrer
Summary: Polarization-sensitive optical coherence tomography (PS-OCT) allows for 3D imaging of biological tissues based on scattering and polarization properties, particularly useful for mapping birefringence in fibrous tissues. Accuracy of birefringence measurements in PS-OCT is highly dependent on signal-to-noise ratio (SNR) and can be affected by mapping artifacts in low SNR situations. A noise bias correction method is proposed to improve accuracy of PS-OCT phase retardation and birefringence measurements by reducing the impact of noise on retardation measurements.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Biochemical Research Methods
Ilyas Saytashev, Yong-Chul Yoon, Benjamin J. J. Vakoc, Srikanth Vasudevan, Daniel X. X. Hammer
Summary: Modern optical volumetric imaging techniques, such as OCT, provide valuable information about living tissue. This study aims to improve in vivo OCT imaging during peripheral neurosurgery in small and large animals by increasing the visualized nerve volume and suppressing motion artifacts in the imaged area. The use of mirror prisms for axially imaged volumes significantly increased the OCT signal intensity.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Chemistry, Medicinal
Haili Xiao, Chao Wei, Huiying Liu, Zhiqiang Li, Cihua Zheng, Jun Luo
Summary: The natural drug lentinan has been found to regulate autophagy, promoting the clearance of myelin debris and enhancing nerve regeneration. The study demonstrated that lentinan activates the AMPK/mTOR signaling pathway, accelerating autophagic flux and promoting the phagocytosis of myelin debris by Schwann cells. These findings suggest that lentinan may be a cost-effective and natural treatment for peripheral nerve injury.
PHYTOTHERAPY RESEARCH
(2023)
Article
Immunology
Yanlin Lang, William Robert Kwapong, Lingyao Kong, Ziyan Shi, Xiaofei Wang, Qin Du, Bo Wu, Hongyu Zhou
Summary: Optical coherence tomography (OCT)/OCT angiography (OCTA) measures were compared between patients with neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD), showing distinct structural and microvascular changes, indicating different pathological mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Optics
Vitaly Sukharenko, Simeon Bikorimana, Roger Dorsinville
Summary: This letter presents a new experimental technique of polarization sensitive quantum optical coherence tomography (PS-QOCT) for imaging and characterization of birefringent materials. The technique has many potential applications in the characterization of micro and nano structures, including biological samples.
Article
Immunology
Joachim Havla, Thivya Pakeerathan, Carolin Schwake, Jeffrey L. Bennett, Ingo Kleiter, Ana Felipe-Rucian, Stephanie C. Joachim, Amelie S. Lotz-Havla, Tania Kumpfel, Markus Krumbholz, Eva M. Wendel, Markus Reindl, Charlotte Thiels, Thomas Lucke, Kerstin Hellwig, Ralf Gold, Kevin Rostasy, Ilya Ayzenberg
Summary: Despite profound neuroaxonal retinal atrophy in both pediatric and adult MOGAD patients with optic neuritis (ON), children showed better visual recovery. Age significantly correlated with visual outcome regardless of retinal atrophy.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemical Research Methods
M. Q. Duan, Robert A. Byers, Simong G. Danby, Sura Sahib, Amy Cha, Chuanbo Zang, John Werth, Roni Adiri, Rosie N. Taylor, Michael J. Cork, Stephen J. Matcher
Summary: Crisaborole 2% ointment, a non-steroidal treatment for atopic dermatitis, may have fewer adverse effects compared to topical corticosteroids. A study using PS-OCT found a differential effect on dermal collagen between Crisaborole and betamethasone valerate (BMV).
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Neurosciences
Chao J. Liu, William Ammon, Viviana Siless, Morgan Fogarty, Ruopeng Wang, Alessia Atzeni, Iman Aganj, Juan Eugenio Iglesias, Lilla Zollei, Bruce Fischl, Jeremy D. Schmahmann, Hui Wang
Summary: The study utilized as-PSOCT to reconstruct human cerebellar tissue, revealing significant variability in granular layer thickness among individuals, while optical properties remained consistent within the same subjects. The high-resolution volumetric morphometry and optical property maps obtained through as-PSOCT have the potential to advance our understanding of cerebellar function and diseases.
Article
Optics
Jianan Fang, Kun Huang, E. Wu, Ming Yan, Heping Zeng
Summary: This article introduces an infrared 3D imaging system capable of detecting three-dimensional structure and reflectivity information. The system operates at single-photon sensitivity and femtosecond timing resolution, enabling imaging under low-light conditions. By nonlinear frequency upconversion and recording with a silicon camera, the presented system achieves high lateral and depth resolutions for 3D reconstruction. Additionally, a numerical denoiser based on spatiotemporal correlation allows the retrieval of object profile and reflectivity even with a detected flux below 0.05 photons/pixel/second. This infrared 3D imager features high detection sensitivity, precise timing resolution, and wide-field operation, offering new possibilities in life and material sciences.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Ophthalmology
Lisette M. Smid, Koenraad A. Vermeer, King T. Wong, Jose P. Martinez Ciriano, Jan H. de Jong, Valentina Davidoiu, Johannes F. de Boer, Mirjam E. J. van Velthoven
Summary: This study found that the combination treatment of PDT and IVB is effective for short-term treatment of type 3 neovascularization, with PDT showing slightly better initial treatment outcomes compared to IVB. Vascular and structural features were significantly improved in all patients, leading to better visual acuity at 18 weeks.
ACTA OPHTHALMOLOGICA
(2021)
Article
Optics
Benjamin Lochocki, Ksenia Abrashitova, Johannes F. de Boer, Lyubov Amitonova
Summary: Compressive imaging using sparsity constraints offers improved spatial resolution and overcomes traditional limits; the use of speckle illumination and single-pixel detection in experimental setups is crucial; oversampling may decrease the resolution and reconstruction quality of compressive imaging.
Article
Biology
Benjamin Lochocki, Baayla D. C. Boon, Sander R. Verheul, Liron Zada, Jeroen J. M. Hoozemans, Freek Ariese, Johannes F. de Boer
Summary: The study conducted comprehensive investigation of amyloid deposits in frozen AD human brain tissue utilizing high-resolution fluorescence and spectroscopic imaging techniques. Variations in plaque types were observed, with Raman spectroscopy indicating changes in protein structure in cored amyloid deposits. Carotenoids were identified as a potential marker for distinguishing plaque areas from non-plaque areas without prior knowledge of their location.
COMMUNICATIONS BIOLOGY
(2021)
Article
Ophthalmology
Milica A. Margeta, Kitiya Ratanawongphaibul, Edem Tsikata, Michele Zemplenyi, Courtney L. Ondeck, Janice Kim, Anne L. Coleman, Fei Yu, Johannes F. de Boer, Teresa C. Chen
Summary: The presence of optic disc hemorrhages in open-angle glaucoma patients was associated with localized neuroretinal rim thickness progression, but not with other progression parameters. Glaucoma progression detected through high-density 3D SD-OCT measurements often preceded the occurrence of DH, indicating that DHs are indicators of ongoing glaucoma progression rather than discrete events causing subsequent progression.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Optics
Liron Zada, Bart Fokker, Heather A. Leslie, A. Dick Vethaak, Johannes F. de Boer, Freek Ariese
Summary: Two simulation programs were developed for optimizing the parameter settings of a stimulated Raman scattering microscopy (SRS) imaging system with lock-in amplifier (LIA) detection. The programs estimated signal focal spot diameters, calibrated signal and noise propagation, and simulated LIA behavior to propose optimal parameter choices. The ultimate goal was to optimize image quality, acquisition speed, resolution, and crosstalk.
JOURNAL OF THE EUROPEAN OPTICAL SOCIETY-RAPID PUBLICATIONS
(2021)
Article
Biochemical Research Methods
Joy Willemse, Reinier R. Wener, Fabio Feroldi, Margherita Vaselli, Johanna M. Kwakkel-van Erp, Eduard A. van de Graaf, Erik Thunnissen, Johannes F. de Boer
Summary: The research utilized PS-OCT imaging to assess airway remodeling in healthy and diseased lungs, finding an increase in airway smooth muscle in diseased lungs except for COPD. The preliminary results require further ex vivo and in vivo studies for confirmation.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Ophthalmology
Ali Riza Cenk Celebi, Elli A. Park, Alice Chandra Verticchio Vercellin, Edem Tsikata, Ramon Lee, Eric Shieh, Hussein Antar, Madeline Freeman, Jing Zhang, Christian Que, Huseyin Simavli, Michael McClurkin, Rong Guo, Tobias Elze, Johannes F. de Boer, Teresa C. Chen
Summary: This study evaluated the structure-function relationship in glaucoma using HVF perimetry and a three-dimensional neuroretinal rim parameter derived from SD-OCT volume scans. The results showed that MDB neuroretinal rim thickness has a strong correlation with visual function, highlighting the potential for improving in vivo imaging in glaucoma using 3D OCT algorithms.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Optics
Christos Messinis, Theodorus T. M. van Schaijk, Nitesh Pandey, Armand Koolen, Ilan Shlesinger, Xiaomeng Liu, Stefan Witte, Johannes F. de Boer, Arie den Boef
Summary: This paper introduces a compact dark-field digital holographic microscope for overlay metrology, with aberration calibration and correction method using nano-sized point scatterers. The method utilizes computational imaging techniques to recover wavefront error and correct for lens aberrations.
Article
Optics
Loes Ettema, Benjamin Lochocki, Jeroen J. M. Hoozemans, Johannes F. de Boer, Freek Ariese
Summary: This study presents a combination of label-free and non-invasive techniques to study the biomolecular composition of Alzheimer's disease (AD) human brain tissue. The results show the presence of autofluorescent carotenoids in the plaques and confirm it using Raman microscopy. The researchers also used stimulated Raman scattering (SRS) microscopy to investigate the shift of the beta-sheet Amide I peak in plaques.
Article
Engineering, Electrical & Electronic
Theodorus T. M. van Schaijk, Christos Messinis, Nitesh Pandey, Armand Koolen, Stefan Witte, Johannes F. de Boer, Arie den Boef
Summary: This study developed an overlay sensor based on digital holographic microscopy that can perform overlay measurements at infrared wavelengths while maintaining functionality at visible wavelengths. The experiments demonstrated good linearity and sensitivity to structures at the top of the wafer. The results show the feasibility of a visible and infrared light-sensitive overlay sensor for integrated circuit material selection.
JOURNAL OF MICRO-NANOPATTERNING MATERIALS AND METROLOGY-JM3
(2022)
Proceedings Paper
Optics
Joy Willemse, Reinier R. Wener, Fabio Feroldi, Margherita Vaselli, Johanna M. Kwakkel-van Erp, Eduard A. van de Graaf, Erik Thunnissen, Johannes F. de Boer
Summary: Polarization-sensitive optical coherence tomography was used to image healthy and diseased lungs ex vivo, revealing differences in alveoli size and airway smooth muscle thickness.
OPTICAL COHERENCE IMAGING TECHNIQUES AND IMAGING IN SCATTERING MEDIA IV
(2021)
Proceedings Paper
Engineering, Biomedical
Benjamin Lochocki, Ksenia Abrashitova, Johannes F. de Boer, Lyubov Amitonova
Summary: Fiber-based endoscopic compressive imaging is a promising field for minimal invasive, in vivo imaging below the diffraction limit and enhanced acquisition time, with potential to surpass the theoretical limits of speckle-based compressive imaging.
ADVANCES IN MICROSCOPIC IMAGING III
(2021)
Article
Ophthalmology
Kitiya Ratanawongphaibul, Edem Tsikata, Michele Zemplenyi, Hang Lee, Milica A. Margeta, Courtney L. Ondeck, Janice Kim, Billy X. Pan, Paul Petrakos, Anne L. Coleman, Fei Yu, Johannes F. de Boer, Teresa C. Chen
Summary: The study compared the onset times of glaucoma progression among different tests and found that high-density 3D SD OCT neuroretinal rim measurements detected glaucoma progression earlier than other structural tests such as DP and 2D RNFL thickness measurements.
OPHTHALMOLOGY GLAUCOMA
(2021)
Proceedings Paper
Engineering, Industrial
T. T. M. van Schaijk, C. Messinis, N. Pandey, V. T. Tenner, K. Koolen, S. Witte, J. F. de Boer, A. J. den Boef
Summary: Digital holographic microscopy provides access to the complex electric field and enables computational propagation of light, allowing for computational corrections of lens aberrations without the need for antireflective coatings on the lens. It is a promising candidate for overlay metrology on semiconductor wafers, as a single holographic image can contain all necessary data for computing the overlay. Additionally, by incoherently adding multiple measurements on a camera using a source with limited coherence length, the reproducibility of the experiment can be improved by eliminating common noise sources typically present in single overlay measurements.
OPTICAL MEASUREMENT SYSTEMS FOR INDUSTRIAL INSPECTION XII
(2021)
Meeting Abstract
Ophthalmology
Kitiya Ratanawongphaibul, Teresa C. Chen, Edem Tsikata, Michele Zemplenyi, Hang Lee, Milica Margeta, Courtney Ondeck, Janice Kim, Billy Pan, Paul Petrakos, Anne L. Coleman, Fei Yu, Johannes de Boer
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)