Article
Biochemical Research Methods
Guangqian Yang, Emile Mehanna, Chao Li, Hongyi Zhu, Chong He, Fang Lu, Ke Zhao, Yubin Gong, Zhao Wang
Summary: This study developed a deep learning method to automatically analyze stents with different thicknesses and vessels implanted with multiple stents, providing effective assistance for the evaluation of stent implantation and post-stent tissue coverage.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Biotechnology & Applied Microbiology
Gongpu Lan, Qun Shi, Yicheng Wang, Guoqin Ma, Jing Cai, Jinping Feng, Yanping Huang, Boyu Gu, Lin An, Jingjiang Xu, Jia Qin, Michael D. Twa
Summary: This study analyzed the natural frequency of corneal tissue using optical coherence tomography-based elastography. The results showed that the natural frequency can reveal local variations in tissue structure and can differentiate different types of tissues. This method could provide additional information on corneal properties and be a useful tool for clinical detection of ocular disease and evaluation of treatment outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Alexander G. Truesdell, Mirvat A. Alasnag, Prashant Kaul, Syed Tanveer Rab, Robert F. Riley, Michael N. Young, Wayne B. Batchelor, Akiko Maehara, Frederick G. Welt, Ajay J. Kirtane, ACC Interventional Counci
Summary: Coronary angiography has been the standard for diagnosing coronary artery disease and guiding percutaneous coronary intervention (PCI). Intravascular imaging (IVI) technologies are used in conjunction with angiography to better assess plaque morphology and optimize PCI. IVI has utility in preintervention assessment, procedural guidance, and postintervention evaluation. IVI's role in reducing major adverse cardiac events in complex lesions is emerging, and further studies are underway. This paper provides an overview of available IVI technologies, reviews evidence supporting their use in PCI, and advocates for broader utilization.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Biochemical Research Methods
Chongyang Wang, Jiang Zhu, Jiawei Ma, Xiaochen Meng, Zongqing Ma, Fan Fan
Summary: The biomechanical characterization of tissues is important for determining pathological status and assessing disease treatment. Optical coherence elastography (OCE) is a high-resolution imaging technique that can map the spatial elasticity distribution of biological tissue. This article reviews OCE methods and summarizes its current applications in biomedicine.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Optics
Yubao Zhang, Jiahui Luo, Xiao Han, Gang Shi, Qin Zhang, Xingdao He
Summary: This study developed and applied a shaker-based optical coherence elastography technique for non-destructive detection of tongue elasticity. The technique showed high resolution and sensitivity, making it potentially valuable in clinical applications.
Article
Medicine, General & Internal
Achuth Nair, Manmohan Singh, Salavat R. Aglyamov, Kirill V. Larin
Summary: The biomechanical properties of the cornea are crucial for the health and function of the eye. This study demonstrates the combined use of two elastography techniques to measure corneal stiffness in a live rabbit model, with the ability to detect changes in stiffness after collagen crosslinking.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemical Research Methods
Yusi Miao, Joseph J. Jing, Zhongping Chen
Summary: Recent advancement in high-speed long-range OCT endoscopy enables tissue compliance characterization, but limited by accurate measurement due to lack of reliable NURD correction method. A robust 2-step NURD correction algorithm was developed and applied in awake human subject to characterize local compliance in nasopharynx for the first time.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Cardiac & Cardiovascular Systems
Kenji Kawai, Yu Sato, Jason Y. Hokama, Rika Kawakami, Takao Konishi, Saikat Kumar B. Ghosh, Renu Virmani, Aloke Finn
Summary: In this study, the histologic effects of intravascular lithotripsy (IVL) on coronary calcified lesions were examined. IVL demonstrated a superior fracturing effect on coronary calcified lesions compared with plain old balloon angioplasty (POBA). Optical coherence tomography (OCT) failed to identify the presence of some calcium fractures and underestimated the depth of fracture when compared with micro-computed tomography (CT).
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Biochemical Research Methods
Gary R. Ge, Behrouz Tavakol, David B. Usher, Desmond C. Adler, Jannick P. Rolland, Kevin J. Parker
Summary: In this study, a high-resolution elastography method in combination with a custom optical coherence tomography system was used to track the biomechanical changes in individual corneal layers. The results showed that the reverberant three-dimensional optical coherence elastography (OCE) technique can identify the elasticity changes associated with CXL treatments and provide insights into the nonlinearity of the elasticity changes.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Computer Science, Artificial Intelligence
Arjun Balaji, Lachlan J. Kelsey, Kamran Majeed, Carl J. Schultz, Barry J. Doyle
Summary: The study aimed to develop a new model with a small memory footprint and fast inference time without sacrificing segmentation quality for automated extraction of geometrical data from IVOCT. By constructing a deep learning method based on capsules, the model showed comparable segmentation quality and robustness to state-of-the-art machine learning methods. The model achieved inference times up to 70% faster on GPU and up to 95% faster on CPU compared to other models.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2021)
Article
Medicine, Research & Experimental
Pin-Chieh Huang, Eric J. Chaney, Edita Aksamitiene, Ronit Barkalifa, Darold R. Spillman, Bethany J. Bogan, Stephen A. Boppart
Summary: This study explores the potential of using stiffness-based metrics to reveal the intrinsic biophysical changes of in vivo melanoma tumors after MH therapy, by exploiting the theranostic functionality of MNPs. It was found that the elasticity alteration of the melanoma tumor after MH treatment depends on both thermal dosage and the morphological features of the tumor. The study suggests that changes in tissue-level elasticity can be a meaningful metric and integrative therapeutic marker for MH treatment, and MM-OCE can be a suitable dosimetry technique.
Review
Cardiac & Cardiovascular Systems
Emrah Erdogan, Retesh Bajaj, Alexandra Lansky, Anthony Mathur, Andreas Baumbach, Christos Bourantas
Summary: Advancements in stent technology and endovascular devices have improved the safety and effectiveness of second-generation drug-eluting stents. However, in-stent restenosis and stent thrombosis still pose challenges in percutaneous coronary intervention. Recent studies have highlighted the value of intravascular imaging in identifying causes of stent failure and guiding therapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Fuxue Deng, Danni Li, Lei Lei, Qiang Yang, Qing Li, Hongtao Wang, Jie Deng, Qiangsun Zheng, Wei Jiang
Summary: The study found that the Apo B/A1 ratio was higher in ACS patients than CCS patients, and also higher in patients with plaque rupture, erosion, or thrombus. A high Apo B/A1 ratio was associated with a high percentage of vulnerable plaques, and negatively related to fibrous cap thickness in lipid-rich plaques.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Engineering, Biomedical
Ruofei Bu, Santosh Balakrishnan, Nicusor Iftimia, Hillel Price, Carlton Zdanski, Sorin Mitran, Amy L. Oldenburg
Summary: This study demonstrated the use of a custom-built anatomic optical coherence elastography system to assess airway wall compliance and severity of inhalation injuries. The results showed a negative correlation between airway compliance measured by aOCE and the severity of steam injuries. Additionally, spatially-resolved compliance maps revealed regional heterogeneity in airway properties.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Reza Fazel, Robert W. Yeh, David J. Cohen, Sunil Rao, Siling Li, Yang Song, Eric A. Secemsky
Summary: The use of intravascular imaging (IVI)-guided percutaneous coronary intervention (PCI) has been increasing among Medicare beneficiaries in the USA. IVI-guided PCI is associated with lower rates of major adverse cardiovascular events and target lesion revascularization compared with standard angiographic guidance.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Medicine, General & Internal
Adam A. Dmytriw, Abdullah Alrashed, Victor X. D. Yang
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2020)
Article
Medicine, General & Internal
Michael D. Hill, Mayank Goyal, Bijoy K. Menon, Raul G. Nogueira, Ryan A. McTaggart, Andrew M. Demchuk, Alexandre Y. Poppe, Brian H. Buck, Thalia S. Field, Dar Dowlatshahi, Brian A. van Adel, Richard H. Swartz, Ruchir A. Shah, Eric Sauvageau, Charlotte Zerna, Johanna M. Ospel, Manish Joshi, Mohammed A. Almekhlafi, Karla J. Ryckborst, Mark W. Lowerison, Kathy Heard, David Garman, Diogo Haussen, Shawna M. Cutting, Shelagh B. Coutts, Daniel Roy, Jeremy L. Rempel, Axel C. R. Rohr, Daniela Lancu, Demetrios J. Sahlas, Amy Y. X. Yu, Thomas G. Devlin, Ricardo A. Hanel, Volker Puetz, Frank L. Silver, Bruce C. Campbell, Rene Chapot, Jeanne Teitelbaum, Jennifer L. Mandzia, Timothy J. Kleinig, David Turkel-Parrella, Donald Heck, Michael E. Kelly, Aditya Bharatha, Oh Young Bang, Ashutosh Jadhav, Rishi Gupta, Donald F. Frei, Jason W. Tarpley, Cameron G. McDougall, Staffan Holman, Joung-Ho Rha, Ajit S. Puri, Marie-Christine Camden, Gotz Thomalla, Hana Choe, Stephen J. Phillips, Joseph L. Schindler, John Thornton, Simon Nagel, Ji Hoe Heo, Sung- Sohn, Marios-Nikos Psychogios, Ronald F. Budzik, Sidney Starkman, Coleman O. Martin, Paul A. Burns, Sean Murphy, George A. Lopez, Joey English, Michael Tymianski
Article
Biochemical Research Methods
Chaoliang Chen, Weisong Shi, Joel Ramjist, Victor X. D. Yang
BIOMEDICAL OPTICS EXPRESS
(2020)
Article
Clinical Neurology
A. A. Dmytriw, J. C. Ku, V. X. D. Yang, N. Hui, K. Uchida, T. Morimoto, J. Spears, T. R. Marotta, J. D. B. Diestro
Summary: Men undergoing endovascular thrombectomy for large-vessel occlusion have better 90-day clinical outcomes compared to women, while the outcomes of recanalization, 90-day mortality, and symptomatic intracranial hemorrhage were comparable between men and women.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Engineering, Multidisciplinary
Ming Zhang, Haofei Liu, Zongxi Cai, Cuiru Sun, Wei Sun
Summary: This study improved analytical methods for estimating residual stress in the aorta by addressing the limitations related to residual deformations, load-free conditions, and mismatches in residual stretch. The proposed method showed tensile residual stresses in both circumferential and axial directions in the media, contrasting with other methods. The method also demonstrated significant influences of axial residual stretch and opening angles on residual stress and in vivo stress distribution.
APPLIED MATHEMATICAL MODELLING
(2021)
Article
Mechanics
Jun Li, Chuanwei Li, Linan Li, Qi Wang, Zhiyong Wang, Shibin Wang, Cuiru Sun
Summary: This study focuses on the fracture behavior of stiff-thin-film-on-soft-substrate structures (STFSS) under biaxial stress state, using a self-developed biaxial tension rig for experimental research. The analysis and discussion include the design and fabrication of specimens, as well as the influence of biaxial loading ratio and prefab cracks on STFSS fracture behavior. The experimental results align well with the theoretical model, validating the feasibility of the investigation for STFSS.
INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
(2021)
Article
Engineering, Biomedical
Ming Zhang, Haofei Liu, Zongxi Cai, Cuiru Sun, Wei Sun
Summary: This study presents a framework combining experiments, constitutive modeling, and computer simulation to quantify the subject-specific three-dimensional residual stress field of the aortic wall. The proposed framework was effective in quantifying the three-dimensional subject-specific residual stress field and yielded accurate results in terms of residual stress estimation for the aortic sample.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Cardiac & Cardiovascular Systems
Qingyi Guo, Jinlong Chen, Haofei Liu, Cuiru Sun
Summary: In this study, we developed a vascular inflation test method using intravascular optical coherence tomography and inverse parametric estimation. The proposed method allows for measuring the mechanical properties of each layer of a blood vessel without splitting up the wall. Experimental results demonstrated the accuracy of the method, making it a useful tool for characterizing the mechanical properties of blood vessels.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2023)
Article
Optics
Xianglong Lin, Jinlong Chen, Yongzheng Hu, Xiaowei Feng, Haosen Wang, Haofei Liu, Cuiru Sun
Summary: This study proposes an image evaluation index CMGG based on OCT-DVC, which comprehensively considers the attenuation of OCT signals and the breadth and dispersion of the gray level distribution of OCT images. The validity of CMGG is demonstrated through virtual deformation experiments and deformation measurement experiments on pork meat.
Article
Optics
Hao Wu, Jiaqiu Wang, Jorge Alberto Amaya Catano, Cuiru Sun, Zhiyong Li
Summary: In this study, a digital volume correlation (DVC)-based optical coherence elastography (OCE) method with inverse compositional Gauss-Newton (IC-GN) algorithm and second-order shape function is proposed. The OCE method achieved measurement errors of displacement and strain less than 0.2 voxel and 4 x 10-4, respectively. The use of a second-order shape function improved the matching of complex deformation and reduced speckle rigidity-induced error. Compared to conventional methods, this OCE method could track a larger strain range up to 0.095 and reduce relative error by 30-50%. This OCE method has the potential to be an effective tool for characterizing the mechanical properties of biological tissue.
Article
Materials Science, Multidisciplinary
J. Chen, H. Wang, H. Zhang, Q. Guo, X. Lin, H. Liu, C. Sun
Summary: This study introduces an improved optical coherence elastography (OCE) method that uses digital volume correlation (DVC) and distortion correction to measure full-field vascular deformation. Refractive index normalization and refractive distortion correction were used to recover the actual shape of the vascular wall imaged by optical coherence tomography (OCT). The displacement fields calculated by DVC were also corrected. The proposed method has the potential to be an effective nondestructive measurement method of vascular mechanics.
EXPERIMENTAL MECHANICS
(2023)
Article
Engineering, Biomedical
Han Han, Baolei Guo, Peng Gao, Fan Yang, Cuiru Sun, Nicholas A. A. Hill, Haofei Liu
Summary: Computer modeling and numerical simulation are crucial in studying aortic dissection, but tear propagation has not been adequately modeled. In this study, a cohesive zone method with a bilinear traction-separation law is used to model in-plane dissection propagation between elastic lamellae. The model allows quantitative predictions and reveals new findings on the influence of geometrical parameters, loading conditions, residual stress, and pressure difference on tear propagation. The findings include the role of axial stretch, residual stress, and damage modes in determining the critical pressure for tear propagation.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2023)
Article
Biochemical Research Methods
Xianglong Lin, Jinlong Chen, Cuiru Sun
Summary: This study proposes an OCE-DVC method for measuring deeper biological tissue deformation, which uses a reliability layer guided displacement tracking strategy and parallel computing to achieve measurement in deep regions of OCT images, increasing the depth of quantitative characterization of displacement and strain.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Optics
Xianglong Lin, Jinlong Chen, Xiaowei Feng, Haosen Wang, Ruixin Li, Hao Liu, Haofei Liu, Cuiru Sun
Summary: This article introduces a tissue engineering scaffold optical coherence elastography (TES-OCE) method for visualizing the full-field 3D strain fields of tissue engineering scaffolds and exploring the relationship between mechanical stimulation and cell differentiation. The semi-continuous digital volume correlation (SC-DVC) method based on a material component identification algorithm is used to automatically extract scaffold architecture information and obtain accurate 3D strain fields. The experimental results show that the loads and water absorption of the scaffold significantly affect the 3D tissue shear strain field, and thus cell differentiation fate can be modulated by loading culture and scaffold pore structure.
OPTICS AND LASERS IN ENGINEERING
(2023)
Article
Chemistry, Physical
Zhixin Liu, Weidong Liu, Qi Chen, Yongzheng Hu, Yurun Li, Xiaoya Zheng, Dian Fang, Hai Liu, Cuiru Sun
Summary: In this study, a real-time and high-resolution viscoelastic response-optical coherence elastography (VisR-OCE) method based on acoustic radiation force (ARF) excitation and optical coherence tomography (OCT) imaging was proposed. The optimal experimental parameters were determined through numerical simulation, and the influences of material parameters were evaluated. The accuracy of the VisR-OCE method was validated by comparing with the tensile test, showing a difference of about 3% in the relaxation time constant of phantoms.
