期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 15, 期 5, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3486543
关键词
phase-sensitive measurement; spectral domain optical coherence tomography; tissue nanomotion; organ of Corti; hearing
资金
- National Institute of Deafness and other Communication Disorders [R01DC010399, R01DC010201, R01DC00141]
Hearing loss can mean severe impairment to the quality of life. However, the biomechanical mechanisms of how the hearing organ, i.e., the organ of Corti (OC), responds to sound are still elusive, largely because there is currently no means available to image the 3-D motion characteristics of the OC. We present a novel use of the phase-sensitive spectral domain optical coherence tomography (PSOCT) to characterize the motion of cellular compartments within the OC at a subnanometer scale. The PSOCT system operates at 1310 nm with a spatial resolution of similar to 16 mu m and an imaging speed of 47,000 A-lines/s. The phase changes of the spectral interferograms induced by the localized tissue motion are used to quantify the vibration magnitude. Fourier transform analysis of the phase changes improves the system sensitivity to sense minute vibrations smaller than 1 nm. We demonstrate that the PSOCT system is feasible to image the meaningful vibration of cellular compartments within the OC with an unprecedented sensitivity down to similar to 0.5 angstrom (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3486543]
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