期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 15, 期 5, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3497565
关键词
pulse modulation; second harmonic generation imaging; collagen modulation postchemotherapy; drug resistance
资金
- Institute of Bioengineering and Nanotechnology
- BMRC [R185-001-045-305]
- A*STAR of Singapore
- Ministry of Education [R-185-000-135-112]
- Janssen-Cilag [R-185-000-182-592]
- Singapore-MIT Alliance Computational and Systems Biology [C-382-603-004-001]
- SMART BioSyM and Mechanobiology Institute, Singapore
Pulse-modulated second harmonic imaging microscopes (PM-SHIMs) exhibit improved signal-to-noise ratio (SNR) over conventional SHIMs on sensitive imaging and quantification of weak collagen signals inside tissues. We quantify the spatial distribution of sparse collagen inside a xenograft model of human acute myeloid leukemia (AML) tumor specimens treated with a new drug against receptor tyrosine kinase (ABT-869), and observe a significant increase in collagen area percentage, collagen fiber length, fiber width, and fiber number after chemotherapy. This finding reveals new insights into tumor responses to chemotherapy and suggests caution in developing new drugs and therapeutic regimens against cancers. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3497565]
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