期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 14, 期 2, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3088029
关键词
multiphoton microscopy; human esophageal stroma; diagnosis
资金
- National Natural Science Foundation of China [60508017, 60678054]
- Natural Science Foundation of Fujian Province of China [2007J0007, C0720001]
- Science and Technology Planning Key Program of Fujian Province [2008Y0037]
- Program for New Century Excellent Talents in University [NCET-07-0191]
Intrinsic two-photon excited fluorescence (TPEF) and second-harmonic generation (SHG) signals are shown to differentiate between normal and neoplastic human esophageal stroma. It was found that TPEF and SHG signals from normal and neoplastic stroma exhibit different organization features, providing quantitative information about the biomorphology and biochemistry of tissue. By comparing normal with neoplastic stroma, there were significant differences in collagen-related changes, elastin-related changes, and alteration in proportions of matrix molecules, giving insight into the stromal changes associated with cancer progression and providing substantial potential to be applied in vivo to the clinical diagnosis of epithelial precancers and cancers. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3088029]
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