期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 14, 期 6, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3269676
关键词
harmonic generation microscopy; dermatology; noninvasive; in vivo; human skin; high penetrability; high resolution
资金
- National Health Research Institute of Taiwan [NHRI-EX98-9201EI]
- NTU Research Center for Medical Excellence
- NTU [98R0036-01]
The ability to in vivo image deep tissues noninvasively with a high resolution is strongly required for optical virtual biopsy. Higher harmonic generation microscopy, combined with second- and third-harmonic generation microscopies, is applied to 17 Asian volunteers' forearm skin. After continuous observation for 30 min, no visible damage was found. Our study proves that harmonic generation biopsy (HGB) is able to satisfy the safety requirement and to provide high penetrability (similar to 300 mu m) and submicron resolution all at the same time and is a promising tool for future virtual biopsy of skin diseases. In contrast to a previous study on fixed human skin specimens, a much improved penetrability and much reduced resolution-degradation versus depth are found in this in vivo examination. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3269676]
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