Article
Polymer Science
Xiaochun Yin, Meixia Du, Zhongming Sun, Hai Zhu, Pei Xu, Huiyao Wang
Summary: Keratin/chitosan hybrid hydrogels were developed by integrating keratin with chitosan through alkaline freeze-thaw cycles. The resulting hydrogels exhibited honeycomb-like structures and excellent mechanical properties. Hydrogel C, with a keratin/chitosan ratio of 3/2, showed the highest compressive stress and strain. It also demonstrated effective controlled release profiles for different drugs at varying pH and temperatures.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Zhishu Bao, Ailing Yu, Hui Shi, Yuhan Hu, Bo Jin, Dan Lin, Mali Dai, Lei Lei, Xingyi Li, Yuqin Wang
Summary: In this study, a glycol chitosan/oxidized hyaluronic acid hydrogel film for dual ophthalmic drug delivery was fabricated successfully. The hydrogel films exhibited a stepwise release of levofloxacin and dexamethasone, demonstrating potent antibacterial and anti-inflammatory activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Multidisciplinary Sciences
Wenjun Feng, Zhengke Wang
Summary: Chitosan (CS) and graphene oxide (GO) nanocomposites have great potential in biomedical applications. Nanocomposites based on CS and GO, with the synergistic effect between them, can be used in various forms for drug delivery, wound healing, bone tissue engineering, and biosensors.
Article
Pharmacology & Pharmacy
Minoo Ghanavi, Ali Khoshandam, Shaghayegh Aslzad, Marziyeh Fathi, Abolfazl Barzegari, Elaheh Dalir Abdolahinia, Khosro Adibkia, Jaleh Barar, Yadollah Omidi
Summary: Due to the unique structure of the human eye, ocular drug delivery faces challenges such as low bioavailability. In-situ gel-forming mucoadhesive hydrogels can improve ocular bioavailability. Chitosan has been used in the preparation of these hydrogels. Water-soluble chitosan was obtained and gel formation was accomplished using sodium beta-glycerophosphate and sodium bicarbonate. The prepared hydrogel showed sustained-release and antibacterial activity in vitro.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Ming Sun, Lidi Cheng, Zexian Xu, Liqiang Chen, Yanshan Liu, Yaoxiang Xu, Dongyang Zhou, Xiuxiu Zhang, Qihui Zhou, Jian Sun
Summary: This study aims to explore the potential feasibility of a novel temperature-sensitive hydrogel-based dual sustained-release system for the repair and treatment of infectious jaw defects. The results indicate that the system shows outstanding sustained-release ability, biocompatibility, and antibacterial properties. This study provides new insights for the treatment of infectious jaw defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kazharskaia Mariia, Muhammad Arif, Jie Shi, Fulai Song, Zhe Chi, Chenguang Liu
Summary: A novel polysaccharide composite hydrogel has been developed in this study through a freeze-dried process, showing improved microstructure and excellent drug release performance. The experimental results suggest that the hydrogel has the potential to enhance wound healing efficiency.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Niloufar Khosravi, Leila Youseftabar-Miri, Faten Divsar, Sara Hallajian, Kaynaz Hafezi
Summary: A biocompatible and biodegradable hydrogel nanocomposite was synthesized for controlled and sustained release of gabapentin. The hydrogel composite exhibited high drug encapsulation and loading efficiency, and the drug release followed the Higuchi kinetics model and Fick-ian diffusion mechanism. The chitosan-based hydrogel showed excellent biocompatibility and thermosensitive properties, making it a promising drug carrier.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Jon Andrade del Olmo, Leyre Perez-Alvarez, Virginia Saez Martinez, Sandra Benito Cid, Leire Ruiz-Rubio, Raul Perez Gonzalez, Jose Luis Vilas-Vilela, Jose Maria Alonso
Summary: In the biomedical community, there has been a focus on developing antibacterial coatings to prevent implant-associated infections. Traditional mono-functional antibacterial strategies have not been sufficient for long-term success. Researchers have recently turned their attention to novel bifunctional or multifunctional antibacterial coatings that combine multiple antibacterial mechanisms. In this study, chitosan-based hydrogel coatings with genipin and polyethylene glycol crosslinking agents were created on a Ti6Al4V surface. These hydrogel coatings demonstrated excellent biocompatibility, as well as the ability to promote cell proliferation and differentiation. Additionally, they showed outstanding bacteria-repelling and contact killing ability. The controlled release of drugs could further enhance their multifunctional antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Jie Cai, Jiaming Guo, Shige Wang
Summary: Postoperative adhesion is a common complication after surgery, involving the formation of fibrous bridges between different layers of tissues. Despite progress in understanding the mechanism, effective prevention of adhesion is still challenging. Hydrogels, as water-expanding polymers with drug-loading capability, have shown promising antifouling abilities for preventing postoperative adhesion. This review summarizes the current research status of hydrogels as anti-adhesion barriers, highlights their characteristics in preventing adhesion, and discusses future research directions.
Article
Materials Science, Multidisciplinary
Shaghayegh Aslzad, Pouria Savadi, Elaheh Dalir Abdolahinia, Yadollah Omidi, Marziyeh Fathi, Jaleh Barar
Summary: Ophtalmic drug therapy is a major pharmaceutical challenge due to ocular barriers. The development of novel ophthalmic delivery systems is necessary to overcome these barriers. In this study, an in situ forming composite hydrogel was developed using natural polymers to deliver betamethasone to the eye.
MATERIALS TODAY COMMUNICATIONS
(2022)
Review
Polymer Science
Karen Guillen-Carvajal, Benjamin Valdez-Salas, Ernesto Beltran-Partida, Jorge Salomon-Carlos, Nelson Cheng
Summary: Hydrogels are versatile biomaterials with three-dimensional, cross-linked, highly hydrated polymeric networks. They have a variety of biochemical and biophysical properties, allowing for diffusion of diverse molecules and control of cellular interactions. Hydrogels can be molded into different structures resembling surrounding tissues and bone defects. Their application in bone tissue engineering has garnered significant attention due to the beneficial bone improvement results achieved. Synthetic polymers have played a key role, but there is a trend towards using biological precursors like chitosan, collagen, and gelatin for their high biocompatibility, degradability, and mechanical control.
Article
Nanoscience & Nanotechnology
Sreekanth Reddy Obireddy, Wing-Fu Lai
Summary: In this study, a new type of nanocomposites was designed as a carrier for controlled delivery of bioactive agents. The nanocomposites showed pH-responsive behavior, reactive oxygen species (ROS)-generating capacity, and cell type-dependent toxicity. This research demonstrates the high potential of the nanocomposites for use in bioactive agent delivery and their potential as pH-responsive carriers for therapeutic applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Polymer Science
Regina R. Vildanova, Svetlana F. Petrova, Sergey V. Kolesov, Vitaliy V. Khutoryanskiy
Summary: Preparation of stable hydrogels using charge-complementary polyelectrolyte chains offers practical advantages over the use of organic crosslinking agents. This study utilizes natural polyelectrolytes-chitosan and pectin-with their biocompatibility and biodegradability. Different molecular weights of pectin are used to prepare hydrogels with varying rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels can release the cytostatic drug cisplatin over an extended period, potentially improving the effectiveness of cancer treatment.
Review
Chemistry, Applied
Amol D. Gholap, Satish Rojekar, Harshad S. Kapare, Nikhar Vishwakarma, Sarjana Raikwar, Atul Garkal, Tejal A. Mehta, Harsh Jadhav, Mahendra Kumar Prajapati, Uday Annapure
Summary: Chitosan, a natural polysaccharide derived from chitin, holds great potential as a biomaterial in various biomedical applications due to its biocompatibility, biodegradability, antibacterial activity, and ease of modification. This review provides an overview of the use of chitosan scaffolds in tissue engineering, regenerative medicine, and drug delivery systems. It highlights the structural and biological properties of chitosan and explores different fabrication methods, such as gelation, electrospinning, and 3D printing. The review emphasizes the role of chitosan scaffolds in promoting cell adhesion, proliferation, and differentiation for tissue regeneration, as well as their potential in wound healing and infection management. Additionally, it discusses the challenges and future objectives in scaffold design, mechanical properties, and understanding interactions with host tissues.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Xiaodan Zhang, Danyi Wei, Yang Xu, Qiang Zhu
Summary: Hyaluronic acid, a naturally-occurring polysaccharide in ophthalmic tissues, has a wide range of applications in the treatment of ocular diseases. Recent advances in HA-based drug delivery systems have shown the importance of rational selection of molecular weight and amount of HA for diverse delivery systems.
CARBOHYDRATE POLYMERS
(2021)