Article
Pharmacology & Pharmacy
Yang Yang, Fuwei Yang, Xiaotian Shan, Jiamin Xu, Wenjie Fang, Juan Zhou, Lipeng Qiu, Jinghua Chen
Summary: The pH/reduction dual sensitive PCT polymers have been synthesized to promote rapid release of drug-loaded micelles at tumor site, showing strong cytotoxicity against tumor cells and better inhibitory effect on tumor growth compared to control micelles. The PCT micelles can be depolymerized in intracellular acidic and reductive environment to release drugs rapidly, indicating great potential for intercellular delivery of antitumor drugs.
Article
Medicine, Research & Experimental
Samara Bonesso dos Reis, Juliana de Oliveira Silva, Fernanda Garcia-Fossa, Elaine Amaral Leite, Angelo Malachias, Gwenaelle Pound-Lana, Vanessa Carla Furtado Mosqueira, Monica Cristina Oliveira, Andre Luis Branco de Barros, Marcelo Bispo de Jesus
Summary: pH-sensitive liposomes showed fast accumulation and intracellular release of doxorubicin in tumor cells, leading to apoptosis. The cytotoxicity of pH-sensitive liposomes can be enhanced by chloroquine and E64d.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Carolina Henriques Cavalcante, Renata Salgado Fernandes, Juliana de Oliveira Silva, Caroline Mari Ramos Oda, Elaine Amaral Leite, Geovanni Dantas Cassali, Ives Charlie-Silva, Bianca Helena Ventura Fernandes, Lucas Antonio Miranda Ferreira, Andre Luis Branco de Barros
Summary: The developed pH-sensitive micelles encapsulating DOX showed promising results with small diameter, high stability, low toxicity, and significantly better inhibition of tumor growth compared to other forms of DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yi Li, Hong Yu Yang, Doo Sung Lee
Summary: Injectable hydrogels are a unique type of hydrogels formed upon injection into living bodies, with various features and potential applications. Biodegradability is an important property of injectable hydrogels, allowing removal after tasks completion.
Article
Biochemical Research Methods
Arun Mondal, Shreya Das, Sk. Mursed Ali, Soumya Kolay, Arunima Sengupta, Mijanur Rahaman Molla
Summary: Dynamic covalent poly(disulfide)-based cross-linked nanonetworks with pH-and redox-responsive degradation features were fabricated for stable noncovalent encapsulation and triggered cargo release. A bioderived lipoic acid-based Gemini surfactant-like amphiphilic molecule was synthesized for the preparation of nanonetworks. The nanonetworks showed stable self-assembled structure in the presence of blood serum and below the critical aggregation concentration.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Polymer Science
Chao Lv, Jia Gao, Kun An, Jingjing Nie, Junting Xu, Binyang Du
Summary: A series of pH-sensitive and thermosensitive amphiphilic pentablock copolymers were self-assembled into micelles with different morphologies and structures, exhibiting varying thermosensitive behavior and nanostructures under different pH conditions.
Article
Chemistry, Physical
Chufen Yang, Delin Wang, Wenyao Liu, Zexiong Yang, Teng He, Fang Chen, Wenjing Lin
Summary: In this study, folate (FA) modified dual pH/reduction-responsive mixed polymeric micelles were successfully assembled for high loading, controlled release, and active targeted delivery. The micelles showed excellent drug loading capacity and encapsulation efficiency, and demonstrated well-controlled release performance in neutral and acidic environments. Cytotoxicity assays further revealed the superior inhibitory effect of FA-modified micelles on cancer cells. These findings suggest that the developed micelles have great potential for anticancer drug delivery.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Biochemical Research Methods
Hongping Li, Ru Zhou, Jinlin He, Mingzu Zhang, Jian Liu, Xingwei Sun, Peihong Ni
Summary: This study successfully constructed biocompatible, biodegradable nanoparticles sensitive to glucose for insulin release in high blood glucose environments. The nanoparticles showed promising potential for diabetes treatment through controlled insulin release.
BIOCONJUGATE CHEMISTRY
(2021)
Review
Chemistry, Physical
Jiahao Shi, Bin Ma, Yuhe Zhang, Haiyang Yong, Zhili Li, A. Sigen, Xiaobei Huang, Dezhong Zhou
Summary: Cancer therapy is a global challenge, but a variety of promising anticancer therapeutics have been developed. However, their direct administration often fails to achieve the desired efficacy due to low bioavailability and poor tissue selectivity. Polymers offer advantages for drug delivery, yet are generally poorly targeted to the tumor microenvironment (TME). The relatively lower acidity of the TME provides a specific trigger for the development of polymers for targeted delivery, and this article summarizes the strategies, mechanisms, and applications of acidity-sensitive polymers for delivering various anticancer therapeutics.
CHEMISTRY OF MATERIALS
(2023)
Article
Materials Science, Biomaterials
Alexandra Sousa, Vegard Boroy, Agnethe Baeverud, Kjersti Julin, Annette Bayer, Morten Strom, Mona Johannessen, Natasa Skalko-Basnet, Sybil Obuobi
Summary: Nucleic acid-based materials have great potential for antimicrobial drug delivery. This study focuses on the stability and antibacterial properties of micellar nanocarriers derived from amphiphilic DNA strands against bacterial biofilms. By using a cationic amphiphilic antibiotic, the stability of the micelles is enhanced, their antibacterial activity remains intact, and they can penetrate bacterial biofilms and impact their metabolic activity. The PMB micelles are also highly safe and biocompatible, making them suitable for application against P. aeruginosa biofilm-colonized skin wounds.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
Mohamed Alaa Mohamed, Ajay Singh, Paras N. Prasad, Chong Cheng
Summary: Delivery of chemotherapeutics to cancer cells using polymeric micelles is a promising strategy for cancer treatment. However, the limited stability of micelles, premature drug release, and off-target effect hinder their utilization as effective drug delivery systems. In this study, pH-sensitive crosslinked polymeric micelles were designed to address these challenges and showed remarkable promise as smart drug delivery systems for cancer therapy.
Article
Polymer Science
Avnish Kumar Mishra, Junsub Lim, Jaeyong Lee, Soyeong Park, Yeseong Seo, Heedong Hwang, Jin Kon Kim
Summary: pH-sensitive and stable PNVP-b-P4VP micelles with low critical micelle concentration were successfully synthesized and showed excellent drug release capabilities under different pH conditions. The release of DOX could be effectively regulated by controlling pH, demonstrating high drug loading efficiency and good biocompatibility.
Article
Biotechnology & Applied Microbiology
Shudi Yang, Weiliang Chen, Wei Li, Jingcheng Song, Yue Gao, Wenhui Si, Xiaoping Li, Baowei Cui, Tongtong Yu
Summary: The study prepared CD44-targeted pH-responsive micelles for efficient delivery and release of doxorubicin based on the overexpressed CD44 receptor and mild acidic microenvironment of tumor cells. These micelles exhibited enhanced cellular uptake and cytotoxicity, as well as excellent tumor-targeting effects in vitro and improved anti-tumor effects with reduced side effects in vivo.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lei Shi, Shuting Lu, Tiedong Sun, Gaolei Xi, Zhifei Chen, Kejing Xu, Xu Zhao, Meihua Shen, Tao Jia, Xiuhua Zhao
Summary: Stimuli-responsive polymeric micelle is a research hotspot as a drug carrier material, which can reduce damage of anticancer drugs to healthy tissues and enrich drug concentration at tumor sites. SRPM with fluorescence imaging capability can be used for drug delivery and therapy monitoring, providing a promising approach for developing new pharmaceutical preparations.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Iloh Son, Yujin Lee, Jinsu Baek, Miran Park, Daeho Han, Seung Kyu Min, Dongwon Lee, Byeong-Su Kim
Summary: A novel hydrophobic epoxide monomer with a pH-responsive cleavable linkage was successfully synthesized to form amphiphilic block copolymer micelles, demonstrating high loading capacity, excellent stability, tunable release efficiency, and high cell viability. Quantum mechanical calculations showed the monomer's higher hydrophobicity compared to other analogues, and cellular uptake and in vivo therapeutic efficacy confirmed the enhanced stability and pH-responsive degradation of the micelles. This study provides a new platform for versatile smart polymeric drug delivery systems with high loading efficiency and tailorable release profiles.
Article
Materials Science, Biomaterials
Shan Gao, Wanlin Zhang, Xingxing Zhai, Xue Zhao, Jianxin Wang, Jie Weng, Jianshu Li, Xingyu Chen
Summary: Researchers have developed a double-layer drug-loaded microneedle patch with antibacterial and angiogenesis-promoting properties, which can accelerate the healing of diabetic wounds.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Xinyuan Xu, Peiyu Qiu, Mingyang Sun, Jun Luo, Peng Yu, Libang He, Jianshu Li
Summary: Composites have been widely used in various industries, especially in the dental and orthopedic fields. However, the traditional methods of improving mechanical strength and visibility have drawbacks such as complexity, poor distribution, and long production times. Therefore, developing an integrated material with both reinforced fillers and radiopacity is of great economic and social significance.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Cheng Cheng, Jiayun Ma, Jinling Zhao, Haiying Lu, Yang Liu, Chuanshi He, Man Lu, Xiaohong Yin, Jianshu Li, Mingming Ding
Summary: Based on disulfide-enriched multiblock copolymer vesicles, this study presents a straightforward sequential drug delivery system with dual-redox response that releases hydrophilic doxorubicin hydrochloride (DOX center dot HCl) and hydrophobic paclitaxel (PTX) under oxidative and reductive conditions, respectively. When compared to concurrent therapeutic delivery, the spatiotemporal control of drug release allows for an improved combination antitumor effect. The simple and smart nanocarrier has promising applications in the field of cancer therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Xian Qin, Li Zhu, Yuan Zhong, Yi Wang, Guicheng Wu, Juhui Qiu, Guixue Wang, Kai Qu, Kun Zhang, Wei Wu
Summary: Biomimetic cell membrane camouflaged technology is a feasible and efficient way to realize the biological functions of nanoparticles. However, the self-assembly and pathological dependent on-demand cargo release of cell membrane camouflaged nanocarriers limit their practical applications. In this study, a spontaneously right-side-out-orientated coupling-driven ROS-sensitive nanotherapeutic has been constructed for target endothelial cells repair through the synergistic effects of spontaneously right-side-out-orientated camouflaging. The findings provide a powerful and universal approach for developing the biomimetic cell membrane camouflaged nanotechnology.
Review
Food Science & Technology
Yimeng Fang, Jiahui Ma, Pengyu Lei, Lei Wang, Junying Qu, Jing Zhao, Fan Liu, Xiaoqing Yan, Wei Wu, Libo Jin, Hao Ji, Da Sun
Summary: T2DM is difficult to prevent and cure, leading to the development of a treatment strategy combining diet therapy and traditional medication. Konjac flour and its derivatives, especially Konjac glucomannan (KGM), have gained popularity as a natural and healthy product. KGM plays an important role in T2DM by extending gastric emptying time, increasing satiety, promoting liver glycogen synthesis, improving intestinal flora and the metabolic system through various molecular pathways, and protecting the liver and kidneys. This article outlines the physicochemical features of KGM and emphasizes its advantages as a meal for special medical purposes in T2DM.
Article
Engineering, Biomedical
Haojie Chen, Pengyu Lei, Hao Ji, Qinsi Yang, Bo Peng, Jiahui Ma, Yimeng Fang, Linkai Qu, Hua Li, Wei Wu, Libo Jin, Da Sun
Summary: With the advancement in the study of bacteria within the human body, bacterial-based drug delivery system has emerged as a biomimetic platform that can retain biological functions. Escherichia coli Nissle 1917 (ECN) has gained attention as a biological carrier in the treatment of inflammatory bowel disease and tumor due to its biocompatibility and targeting ability. ECN acts as a natural capsule and can be modified or genetically engineered to enhance its function and survival in harsh environments. This review discusses the properties of ECN, its relationship with inflammation and tumor, and strategies to modify it as a delivery carrier for disease treatment.
MATERIALS TODAY BIO
(2023)
Article
Nanoscience & Nanotechnology
Yongping Lu, Wenjin Ye, Weiqi Kang, Shuaibing Wang, Zhongqiang Zhu, Xingyu Chen, Jianshu Li
Summary: In this study, a low-cost and highly efficacious wound-healing material, keratin-hyperbranched polymer hydrogel-M (KHBP-M), was developed by mixing reduced keratin, hyperbranched polymer (HBP), and MnO2 nanoparticles. The composite gel showed antibacterial effects against both Gram-positive and Gram-negative bacteria and had excellent ROS-scavenging ability. In an animal model of infected wounds, the KHBP-M hydrogel treated with near-infrared light exhibited the fastest wound-healing rate, reaching 82.98% on day 15.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Kai Xu, Jie Weng, Jianshu Li, Xingyu Chen
Summary: Microneedles (MNs) are a new drug delivery method that has gained attention for their effectiveness, safety, and painlessness. To improve their application, the concept of intelligent stimuli-responsive MNs has been proposed. These MNs can exhibit unique biomedical functions according to changes in the internal and external environment.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Biotechnology & Applied Microbiology
Bangchang Lin, Jiahui Ma, Yimeng Fang, Pengyu Lei, Lei Wang, Linkai Qu, Wei Wu, Libo Jin, Da Sun
Summary: Diabetic foot ulcers cause significant suffering and financial burden for the healthcare system. Negative factors associated with diabetes, such as bacterial biofilms and impaired healing mechanisms, hinder the normal wound healing process and can result in amputations. Establishing an animal experimental model, particularly using zebrafish, contributes to in-depth research on diabetic wound pathology and treatment. This review examines the reasons behind delayed diabetic wound healing, summarizes studies using zebrafish as a diabetic wound model, and provides strategies for improving the zebrafish model.
BIOENGINEERING-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Peng Yu, Yanyan Li, Hui Sun, Hongbo Zhang, Han Kang, Peng Wang, Qiangwei Xin, Chunmei Ding, Jing Xie, Jianshu Li
Summary: A photothermal dual-bionic nanozyme, mimicking antioxidases and hyaluronan synthase, has been developed for effective osteoarthritis (OA) therapy. It can produce heat, scavenge free radicals, and promote chondrogenesis even under inflammatory conditions. This nanozyme regulates anabolic and catabolic processes simultaneously, thereby effectively restoring joint homeostasis and demonstrating an admirable photothermally therapeutic effect on OA.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Yongping Lu, Linming Fan, Jun Wang, Mingxiang Hu, Baogang Wei, Ping Shi, Jianshu Li, Jinyan Feng, Yu Zheng
Summary: The nanodelivery system has limitations in its effectiveness due to short biological half-life and inadequate tumor targeting. The integration of cancer cell membranes (CCM) and nanoparticles has led to the emergence of CCM-based nanoplatforms (CCM-NPs), which have gained significant attention for their unique properties. CCM-NPs not only prolong the blood circulation time of core nanoparticles, but also target tumors effectively. This article discusses the history and development of CCM-NPs, as well as their applications in biomedical research, particularly in cancer therapy.
Review
Chemistry, Multidisciplinary
Xiaoning Sun, Chunmei Ding, Meng Qin, Jianshu Li
Summary: Hydrogel-based biosensors are highly promising for the detection and monitoring of bacterial infections. This review summarizes the recent advancements in this field and discusses the challenges and future development of hydrogel biosensors for bacterial infections.
Article
Nanoscience & Nanotechnology
Qiangwei Xin, Zhengxin Ma, Shiran Sun, Hongbo Zhang, Yan Zhang, Liangrui Zuo, Yifei Yang, Jing Xie, Chunmei Ding, Jianshu Li
Summary: In orthodontic treatment, bacterial infections are a risk to oral health. A self-healing coating based on supramolecular bonding was prepared to improve the antifouling properties of orthodontic appliances. The coating showed excellent antimicrobial activity, surface antifouling properties, and the ability to restore antibiofouling properties at oral temperature and humidity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Miao Zhang, Xu Peng, Yuan Ding, Xiang Ke, Kai Ren, Qiangwei Xin, Meng Qin, Jing Xie, Jianshu Li
Summary: Enhanced joint synergistic lubrication combined with anti-inflammatory therapy is an effective strategy to delay the progression of early osteoarthritis. A pH-responsive cyclic brush zwitterionic polymer (CB) with high drug-loading efficiency was developed, demonstrating superlubrication, sequence controlled release, and anti-inflammatory effects. The CB shows promise as a long-acting lubricating therapeutic agent for OA treatment or other diseases.
MATERIALS HORIZONS
(2023)
Review
Materials Science, Biomaterials
Yongping Lu, Xinyuan Xu, Jianshu Li
Summary: Adhesive materials, both natural and synthetic, have the ability to stick to mucus or epithelial cells. They are widely used in biomedicine due to their unique properties, such as adhesion, biocompatibility, and surface characteristics. They can target specific areas in the human body, improving therapeutic effects and preventing bacterial infections. This review systematically introduces the properties and mechanisms of different types of adhesive materials and explores their applications in drug delivery, antibacterials, tissue repair, and other biomedical fields. The prospects and challenges of using adhesive materials in biomedicine are also discussed.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
