Article
Materials Science, Multidisciplinary
Yufen Han, Yarong Lv, Jia Chen, Ming Yao, Ce Wang, Ping Hu, Yong Liu
Summary: In this study, vascular grafts loaded with puerarin were prepared using electrospinning technology, resulting in fibers with a core-shell structure similar to natural blood vessels. The puerarin-loaded fibers were found to be non-toxic to endothelial cells and had a prolonged drug release cycle.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Polymer Science
Se-Eun Kim, Sung-In Jeong, Kyung-Mi Shim, Kwangsik Jang, Jong-Seok Park, Youn-Mook Lim, Seong-Soo Kang
Summary: The effectiveness of small-diameter vascular grafts depends on their antithrombogenic properties and ability to undergo accelerated endothelialization. In this study, the researchers enhanced the antithrombogenicity of poly(epsilon-caprolactone) (PCL) biomaterial by grafting 2-aminoethyl methacrylate (AEMA) hydrochloride onto the PCL surface and developing a heparin-immobilized PCL nanofibrous scaffold. They also incorporated vascular endothelial growth factor (VEGF) into the scaffold to promote vascular endothelial cell proliferation and prevent thrombosis on the vascular grafts. The physicochemical properties of the grafts were evaluated, and in vivo experiments in rats showed that the modified grafts improved blood vessel function and prevented thrombosis, indicating their potential as functional vascular grafts in vascular tissue engineering.
Review
Engineering, Biomedical
Junpeng Zhu, Xinwang Wang, Lin Lin, Wen Zeng
Summary: Cardiovascular disease is a major cause of death worldwide, and there is a clinical demand for transplantable blood vessels. 3D bioprinting technology has shown significant progress in synthesizing blood vessel grafts with clinical effects. However, challenges remain in synthesizing vascular valves, small diameter vessels, and capillary networks. This review discusses the progress, limitations, and future prospects of 3D bioprinting in these areas.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Review
Biotechnology & Applied Microbiology
Yuanming Li, Ying Zhou, Weihua Qiao, Jiawei Shi, Xuefeng Qiu, Nianguo Dong
Summary: Coronary artery bypass grafting (CABG) is a commonly used procedure in cardiovascular surgery to treat severe coronary atherosclerotic heart disease. Small-diameter tissue-engineered vascular grafts can replace patient vessels, but they are prone to thrombosis and neoplastic endothelial hyperplasia. Improving early endothelialization and avoiding intravascular thrombosis are key to enhancing the long-term patency of these grafts.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Sabrina Rohringer, Christian Grasl, Katharina Ehrmann, Pia Hager, Clemens Hahn, Sophie J. Specht, Ingrid Walter, Karl H. Schneider, Lydia M. Zopf, Stefan Baudis, Robert Liska, Heinrich Schima, Bruno K. Podesser, Helga Bergmeister
Summary: Clinically available small-diameter synthetic vascular grafts (SDVGs) have unsatisfactory patency rates. Autologous implants are still the gold standard, but bioresorbable SDVGs may be an alternative. A new biodegradable, self-reinforcing SDVG is developed with improved biomechanical properties and excellent cyto- and hemocompatibility. Evaluation in rats shows promising results with no complications observed. These new SDVGs may be promising candidates for future clinical use.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Takashi Tanaka, Yasuyuki Abe, Chieh-Jen Cheng, Ryo Tanaka, Akira Naito, Tetsuo Asakura
Summary: The study developed a novel EL-SF double-raschel knitted vascular graft, which effectively prevented thrombus formation and intimal hyperplasia, promoted the adhesion of vascular endothelial cells and cell migration. When implanted into the abdominal aorta of rats, the grafts displayed good patency and remodeling ability without adverse reactions, indicating the potential usefulness of EL-SF artificial vascular grafts for small-diameter requirements.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Yuichi Matsuzaki, Anudari Ulziibayar, Toshihiro Shoji, Toshiharu Shinoka
Summary: The development of small-diameter tissue-engineered vascular grafts using biodegradable materials could revolutionize cardiovascular surgery, but the issue of acute thrombus occlusion remains a significant challenge. Research focuses on inhibiting thrombus formation and extending the release time of anticoagulant heparin, with results from large animal models presenting challenges for future clinical applications.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Biomedical
Yuan Yao, Aung Moe Zaw, Deirdre E. J. Anderson, YeJin Jeong, Joshua Kunihiro, Monica T. Hinds, Evelyn K. F. Yim
Summary: This study presents a promising strategy to stimulate in situ endothelialization on synthetic materials. By using a surface modification method with fucoidan and topography, the researchers achieved in situ endothelialization of polyvinyl alcohol, which is not adhesive to endothelial cells. The conjugation of aminated-fucoidan promoted endothelial monolayer formation and the 2 μm gratings increased endothelial cell migration. The strategy showed potential in improving the long-term performance of synthetic materials, as demonstrated in animal experiments.
BIOACTIVE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Peng Sun, Shujie Yan, Liwei Zhang, Cong Zhang, Haoliang Wu, Shunbo Wei, Boao Xie, Xiaofeng Wang, Hualong Bai
Summary: Recent studies have shown that egg shell membrane (ESM) has the potential to yield rapid re-endothelialization in vitro, making it a promising vascular graft in the clinic. Heparin-coated ESM (HESM) also showed strong anticoagulation properties in vitro and in vivo, indicating its potential for decreasing mural thrombus formation after rat aortic patch angioplasty.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Chunliang Zhang, Ruitao Cha, Chunyuan Wang, Xingming Chen, Zulan Li, Qian Xie, Liujun Jia, Yang Sun, Zhan Hu, Lin Zhang, Fengshan Zhou, Yan Zhang, Xingyu Jiang
Summary: Researchers developed a facile approach to prepare an Rm-functionalized poly-e-caprolactone/poly-D-lysine (Rm@PCL/PDL) tube, which showed excellent bioactivity and good hemocompatibility with great anti-inflammatory effects. The implantation of Rm@PCL/PDL tubes in the carotid artery of rabbits demonstrated good patency and quick remodeling within 21 days. This study highlights the significance of using Rm as a biomaterial for developing personalized or universal small-diameter vascular grafts (SDVGs) in the field of cardiovascular regenerative medicine and organ chip.
Article
Engineering, Biomedical
Jie Shi, Yanjiao Teng, Duo Li, Ju He, Adam C. Midgley, Xiaoqin Guo, Xiudan Wang, Xinran Yang, Shufang Wang, Yakai Feng, Qi Lv, Shike Hou
Summary: In this study, a tri-layered vascular graft was constructed using decellularized extracellular matrix (dECM) to mimic the defining features of native arteries. The results showed that dECM provided a bioactive environment for endothelial cell growth and migration. Additionally, it promoted smooth muscle regeneration and extracellular matrix deposition. This study provides a promising strategy for small-diameter vascular grafts.
MATERIALS TODAY BIO
(2023)
Article
Biotechnology & Applied Microbiology
Xinlong Xie, Qiying Wu, Yuhong Liu, Chunyang Chen, Zeguo Chen, Chao Xie, Mingzhe Song, Zhenlin Jiang, Xiaoke Qi, Sixi Liu, Zhenjie Tang, Zhongshi Wu
Summary: This study evaluated the effect of VEGF on neointimal hyperplasia and local inflammatory responses in decellularized small-diameter vascular grafts. The results showed that local administration of VEGF attenuated neointimal hyperplasia by inducing macrophage M2 polarization and modulating the inflammatory response.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
He Wang, Mengmeng Xing, Weiliang Deng, Meng Qian, Fei Wang, Kai Wang, Adam C. Midgley, Qiang Zhao
Summary: By immobilizing stem cell antigen-1 (Sca-1) antibody, the vascular graft can promote the role of vascular stem/progenitor cells (SPCs) in vascular regeneration and induce rapid vascular regeneration from local tissues and bone marrow.
BIOACTIVE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Sen Yang, Xueni Zheng, Meng Qian, He Wang, Fei Wang, Yongzhen Wei, Adam C. Midgley, Ju He, Hongyan Tian, Qiang Zhao
Summary: Nitrate-functionalized artificial small-diameter vascular grafts showed superior performance in promoting cell infiltration and enhancing cell layer formation compared to unmodified grafts in animal experiments. They also exhibited inhibition of calcification, which is crucial for improving and enhancing long-term successful implantation outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Chunliang Zhang, Qian Xie, Ruitao Cha, Li Ding, Liujun Jia, Lei Mou, Shiyu Cheng, Nuoxin Wang, Zulan Li, Yang Sun, Chuanjue Cui, Yu Zhang, Yan Zhang, Fengshan Zhou, Xingyu Jiang
Summary: Bilayer anticoagulant hydrogel tubes with inner layer containing NFC/PVA-heparin/poly-L-lysine nanoparticles and outer layer made of PCL sheaths were prepared and studied for use as small-diameter vascular grafts. The tubes exhibited prominent anticoagulation, sufficient burst pressure, good compliance, and potential for host cell infiltration and proliferation. The structure, anticoagulant property, and biocompatibility of the inner layer, as well as the impact of outer layer thickness on tube performance and mechanical properties, were investigated. The tissue compatibility and patency of the tubes were evaluated through implantation in animal models.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biophysics
Zhiwen Zeng, Dinghua Liu, Dejian Li, Xiumei Mo
Summary: This paper presents an injectable mussel inspired double cross-linked hydrogel adhesive with excellent biocompatibility and adhesion properties, which was further confirmed by in vivo experiments in mice model. The prepared hydrogel showed good cytocompatibility with L929 cells and human umbilical vein endothelial cells (HUVECs).
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
Xianrui Xie, Dan Li, Yujie Chen, Yihong Shen, Fan Yu, Wei Wang, Zhengchao Yuan, Yosry Morsi, Jinglei Wu, Xiumei Mo
Summary: The gelatin nanofiber sponge offers great potential as an absorbable hemostatic agent for rapid hemostasis, with low density, high surface area, compressibility, and ultrastrong liquid absorption capacity. Studies have shown good cytocompatibility, biocompatibility, and hemostatic capacity of the gelatin nanofiber sponge in both in vitro and in vivo assessments.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Polymer Science
Ahmed A. El-Shanshory, Mona M. Agwa, Ahmed I. Abd-Elhamid, Hesham M. A. Soliman, Xiumei Mo, El-Refaie Kenawy
Summary: This study aimed to develop a composite metronidazole immobilized nanofibrous scaffold based on biopolymers to accelerate the healing of secondary intention wounds. The properties of the scaffold were evaluated, including SEM, FTIR, TGA, water uptake, contact angle, porosity, mechanical properties, and antibacterial activity. In vitro cytocompatibility and in vivo wound healing experiments were also conducted. The results showed that the scaffold significantly accelerated wound healing by augmenting the transforming growth factor signaling pathway and suppressing the pro-inflammatory cytokine IL-6.
Review
Polymer Science
AbdElAziz A. Nayl, Ahmed I. Abd-Elhamid, Nasser S. Awwad, Mohamed A. Abdelgawad, Jinglei Wu, Xiumei Mo, Sobhi M. Gomha, Ashraf A. Aly, Stefan Braese
Summary: This review provides an overview of recent progress in the use of electrospun nanofibers for water purification and oil/water separation, highlighting the importance of the distinctive characteristics of these nanofibers in removing pollutants and achieving efficient separation.
Review
Polymer Science
Abd El Aziz A. Nayl, Ahmed I. Abd-Elhamid, Nasser S. Awwad, Mohamed A. Abdelgawad, Jinglei Wu, Xiumei Mo, Sobhi M. Gomha, Ashraf A. Aly, Stefan Braese
Summary: Electrospinning is a promising and flexible technique to fabricate ultrafine fiber materials with unique characteristics. Electrospun nanofibers have gained considerable attention in the biomedical field, especially in tissue and organ regeneration and mimicking collagen fiber structures. Functionalization of electrospun nanofibers enhances their performance in biomedical applications.
Article
Engineering, Biomedical
Binan Zhao, Yuanzhen Zhang, Dandan Li, Xiumei Mo, Jianfeng Pan
Summary: Compared with other types of hydrogels, natural derived hydrogels possess intrinsic advantages of degradability and biocompatibility. However, their potential applications in biomedical areas are limited due to low mechanical strength. In this study, Hofmeister effect-enhanced gelatin/oxidized dextran hydrogels with improved mechanical properties and biocompatibility were developed to accelerate wound healing. The type of anions induced different physical crosslinking domains, and H2PO4 - treated hydrogels showed enhanced mechanical strength and better biocompatibility. The Hofmeister effect by essential inorganic anions is a promising method to improve natural hydrogels for their medical applications.
ACTA BIOMATERIALIA
(2022)
Correction
Nanoscience & Nanotechnology
W. Wang, W. Nie, D. Liu
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yihong Shen, Xiao Yu, Jie Cui, Fan Yu, Mingyue Liu, Yujie Chen, Jinglei Wu, Binbin Sun, Xiumei Mo
Summary: Cardiovascular disease is the leading cause of death. Biodegradable polymeric stents have attracted significant attention and research interest for their potential in cardiovascular disease treatment due to their degradability. This article reviews the advanced methods for fabricating biodegradable polymeric stents and introduces their functional modifications and future perspectives.
Article
Chemistry, Multidisciplinary
Changming Su, Jing Chen, Xianrui Xie, Zhongfei Gao, Zhenxin Guan, Xiumei Mo, Chunhua Wang, Guige Hou
Summary: Considerable advances have been made in developing materials that promote wound healing and inhibit scar formation. This study presents a multifunctional wound dressing that effectively promotes wound healing and inhibits scar formation, with better results than commercial products in an animal model.
Article
Biophysics
Tonghe Zhu, Jingjing Zhu, Shuyang Lu, Xiumei Mo
Summary: The lack of mechanically matched materials with excellent blood compatibility is the main reason for the failure of artificial blood vessel transplantation. In this study, electrospun biodegradable polyurethane fibers were prepared and analyzed for their chemical structure, microstructure, and thermal properties. The designed PCL-based material is expected to be applied in vascular tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Jie Cui, Xiao Yu, Yihong Shen, Binbin Sun, Wanxin Guo, Mingyue Liu, Yujie Chen, Li Wang, Xingping Zhou, Muhammad Shafiq, Xiumei Mo
Summary: Tissue engineering has gained widespread attention as a method of producing patient-specific tissue constructs for tissue repair. Different types of scaffold materials have been developed, and the choice of materials should consider their mechanical properties, biodegradability, biocompatibility, and bioresorbability. Inorganic materials, with their broad range of physico-chemical properties, can be used as scaffold fillers and offer a good alternative for tissue engineering. This review focuses on the use of inorganic components in electrospun membranes and emphasizes the biological advantages of incorporating inorganic materials in tissue repair.
Article
Biophysics
Muhammad Shafiq, Zhengchao Yuan, Muhammad Rafique, Shinichi Aishima, Hou Jing, Liang Yuqing, Hiroyuki Ijima, Shichao Jiang, Xiumei Mo
Summary: Skin regeneration is hindered by poor vascularization, inflammation, and scar tissue formation. This study uses multiple bioactive peptides to promote wound healing in both healthy and diabetic rat models. The deployment of these peptides in core/shell fibers effectively induces blood vessel regeneration, resolves inflammation, and recruits host cells for skin repair.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Multidisciplinary
Yifan Wu, Lili Song, Muhammad Shafiq, Hiroyuki Ijima, Soo Hyun Kim, Ran Wei, Deling Kong, Xiumei Mo, Kai Wang
Summary: Cardiovascular injuries have significant global morbidity and mortality rates. Synthetic biodegradable polymers offer a promising platform for arterial reconstructions, but current graft options have limitations. This study explored the use of VEGF-binding peptide and SDF-1a peptide to enhance neovascularization and stem/progenitor cell mobilization for vascular regeneration. The peptides were successfully conjugated with a polymer and blended with a high molecular weight polymer to create bioactive vascular grafts. In vivo tests showed that the dual peptide modified grafts had superior patency and tissue regeneration compared to control grafts. These findings have implications for the in situ regeneration of artificial blood vessels.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Kholoud H. Hamza, Ahmed A. El-Shanshory, Mona M. Agwa, Mohamed I. Abo-Alkasem, Esmail M. El-Fakharany, Abdallah S. Abdelsattar, Ali A. El-Bardan, Taher S. Kassem, Xiumei Mo, Hesham M. A. Soliman
Summary: A multifunctional antibacterial biopolymer-based tri-layered hierarchically nanofibrous scaffold was constructed with hydrophilic silk fibroin (SF), fish skin collagen (COL), and hydrophobic poly-3-hydroxybutyrate (PHB) containing amoxicillin (AMX) for wound healing. The scaffold exhibited excellent biocompatibility, significant antimicrobial activity, and accelerated full-thickness wound healing in a rat model. The results suggest its potential as an effective wound dressing scaffold.
Article
Materials Science, Biomaterials
Jing Wang, Yuan Liu, Minmin Lv, Xiaoli Zhao, Kwok Fai So, Hui Li, Mohamed EL-Newehy, Hany EL-Hamshary, Yosry Morsi, Xiumei Mo
Summary: An ideal nerve conduit with topological guidance and biochemical and electrical signal transduction mechanisms is needed for the treatment of peripheral nerve injury. In this study, aligned conductive nanofibrous scaffolds were fabricated and loaded with nerve growth factor (NGF) and Lycium barbarum polysaccharides (LBP). LBP accelerated axon regeneration after severe peripheral nerve injury, and the combination of LBP and NGF promoted nerve cell proliferation and neurite outgrowth. Multiwalled carbon nanotubes (MWCNTs) were introduced to increase electrical conductivity and enhance directional growth and neurite extension of neurons. The combination of conductive fibrous scaffolds and electrical stimulation further promoted cell differentiation and axon outgrowth.
REGENERATIVE BIOMATERIALS
(2023)
