期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 100B, 期 8, 页码 2251-2260出版社
WILEY-BLACKWELL
DOI: 10.1002/jbm.b.32795
关键词
magnesium alloy; corrosion mechanism; in vivo implantation; transmission electron microscopy; interdiffusion
资金
- Korea Institute of Science and Technology project [2E21950]
- Pioneer Research Center Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0028287, 2011-0001704]
- Seoul R&BD program, Seoul Development Institute, Republic of Korea [SS100008]
We elucidated the in vivo corrosion mechanism of the biodegradable alloy Mg10 wt % Ca in rat femoral condyle through transmission electron microscope observations assisted by focused ion beam technique. The alloy consists of a primary Mg phase and a three-dimensional lamellar network of Mg and Mg2Ca. We found that the Mg2Ca is rapidly corroded by interdiffusion of Ca and O, leading to a structural change from lamellar network to nanocrystalline MgO. In contrast to the fast corrosion rate of the lamellar structure, the primary Mg phase slowly changes into nanocrystalline MgO through surface corrosion by O supplied along the lamellar networks. The rapid interdiffusion induces an inhomogeneous Ca distribution and interestingly leads to the formation of a transient CaO phase, which acts as a selective leaching path for Ca. In addition, the outgoing Ca with P from body fluids forms needle-type calcium phosphates similar to hydroxyl apatite at interior and surface of the implant, providing an active biological environment for bone mineralization. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
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