Article
Food Science & Technology
Menglei Wang, Huanxin Zheng, Jiawen Chen, Yingmei Tang, Meixin Feng, Li Li
Summary: This study evaluated the toxicity risk of ZnO NPs in the treatment of inflammatory skin diseases. The results showed that ZnO NPs can activate protective cell autophagy and reduce the viability of inflammatory skin cells. The TRIM16-NRF2-p62 pathway plays a key role in the blockade of autophagy flux and the reduction of cell viability mediated by ZnO NPs.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Materials Science, Biomaterials
Estefania Echeverri, Charlotte Skjoldebrand, Paul O'Callaghan, Anders Palmquist, Johan Kreuger, Gry Hulsart-Billstrom, Cecilia Persson
Summary: Silicon nitride (SiN) coatings with added iron (Fe) and carbon (C) have the potential to reduce metal ion release from metallic implants. This study investigated the effect of Fe and C on the dissolution rate of SiN coatings and their impact on the viability of microglia cells expected at the implant site. The results showed that Fe and C additives reduced ion release and did not compromise cell viability, suggesting their potential for increasing the lifetime and functionality of SiN-coated metallic implants.
BIOMATERIALS SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Xiaohui Nan, Yan Teng, Jiesheng Tian, Zhiyuan Hu, Qiaojun Fang
Summary: BM shows good biocompatibility, but may have an impact on immune response at excessive concentrations, leading to activation of the complement system and inhibition of lymphocyte proliferation; BM can induce reactive oxygen species (ROS) production in macrophages in a dose-dependent manner, but only causes cell membrane damage and cell cycle arrest at high concentrations, approximately 40 times the clinical dosage.
Article
Biochemistry & Molecular Biology
Asmaa M. Abd El-Aziz, Azza El-Maghraby, Andrea Ewald, Sherif H. Kandil
Summary: Electrospun carbon nanofibers modified with hydroxyapatite were fabricated for bone cell proliferation substrate. The modified composites showed higher capability of bone regeneration.
Article
Materials Science, Multidisciplinary
Xinyi Li, Mengjie Ye, Yong-E. Gao, Shengxin Hou, Peng Jia, Peng Xue, Yuejun Kang, Zhigang Xu
Summary: Nanoparticle-based theranostics have become a preferential technology for the diagnosis and treatment of diseases. This study introduces a drug delivery system based on natural silk fibroin (SF NPs). It has been evaluated and found to have high stability, universal drug delivery ability, and good biosafety both in vitro and in vivo.
ADVANCED FIBER MATERIALS
(2022)
Article
Fisheries
Javier Mayor, Alberto Cuesta, Cristobal Espinosa-Ruiz, M. Angeles Esteban
Summary: This study investigated the effects of Astaxanthin (AX) on various fish pathogenic bacteria and fish cell lines. The results showed that AX had different effects on different bacteria and cell lines, providing valuable insights into the mechanism of action of AX in aquaculture.
AQUACULTURE REPORTS
(2023)
Article
Engineering, Biomedical
Claudia Reyes San-Martin, Yue Zhang, Thamir Hamoh, Lotte Berendse, Carline Klijn, Runrun Li, Alina Sigaeva, Hui Ting Li, Jian Tehrani, Aldona Mzyk, Romana Schirhagl, Jakub Kawalko
Summary: Nanodiamonds have various biomedical applications, but their biocompatibility needs to be assessed. This study investigated different sizes and concentrations of nanodiamonds on sperm cells and found that larger particles and lower concentrations are better tolerated. However, overall, nanodiamonds are not universally biocompatible, especially in the capacitated state of cells.
MATERIALS TODAY BIO
(2023)
Article
Polymer Science
Selma Usturk, Ergul Mutlu Altundag, Elvan Yilmaz
Summary: Pullulan/polyHEMA cryogels were synthesized using ECH and EGDMA as crosslinkers, exhibiting different microstructures. The IPN sample showed a more hydrophobic surface and smaller pore size compared to the graft copolymer. Gravimetric studies revealed the degradability of the cryogels in aqueous media, and cell viability tests demonstrated non-toxicity and promotion of cell proliferation for colon carcinoma cells.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Immunology
Yue Zhu, Zhuo Wang, Chao Gao, Lei Zhang, Rubo Sui
Summary: Alzheimer's disease is a global neurological disease that affects the elderly. Current drugs only alleviate symptoms without targeting the underlying causes. Aβ25-35 peptide aggregation is a common mechanism for AD development. Recent research has discovered oxymatrine, a potential neuroprotective agent that inhibits acetylcholinesterase, protects against mitochondrial damage, and prevents Aβ25-35 peptide aggregation. In vitro and in vivo studies have shown the efficacy and safety of oxymatrine, making it a promising multifunctional drug for treating Alzheimer's disease.
INFLAMMOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Adina Gavrila, Rodica Tatia, Ana-Maria Seciu-Grama, Isabela Tarcomnicu, Cristina Negrea, Ioan Calinescu, Christina Zalaru, Lucia Moldovan, Anca D. Raiciu, Ioana Popa
Summary: The aim of this study was to determine the optimal conditions for ultrasound assisted extraction of saponins from Hedera helix L. leaves and evaluate the in vitro biocompatibility of the richest saponin extracts. The study found that the best extraction conditions were a temperature of 50 degrees C, an ultrasound amplitude of 40%, an extraction time of 60 min, a plant material to solvent ratio of 1:20 (w:v), and 80% ethanol as solvent. The extracts were cytocompatible with L929 fibroblast cell lines at concentrations below 200 μg/mL after 48 h of treatment.
Review
Chemistry, Multidisciplinary
Akesh Babu Kakarla, Ing Kong
Summary: This review assesses the role and characteristics of boron nitride nanotubes in biocompatibility studies, providing important information for their potential applications in biomedicine.
Article
Engineering, Biomedical
Dae Hyun Cho, Thomas Avey, Kyoung Hyup Nam, David Dean, Alan A. Luo
Summary: In this study, biodegradable Mg-Zn-Ca-Mn alloys were prepared by squeeze casting, and it was found that increasing Mn content can improve the microstructure and corrosion resistance of the alloys. Samples with Mn showed the best mechanical properties and biocompatibility.
ACTA BIOMATERIALIA
(2022)
Article
Polymer Science
Adam Wawrzynkiewicz, Wioletta Rozpedek-Kaminska, Grzegorz Galita, Monika Lukomska-Szymanska, Barbara Lapinska, Jerzy Sokolowski, Ireneusz Majsterek
Summary: This study evaluated the in vitro biocompatibility of four specific universal dental adhesives and found significant differences in their toxicity, with G-Premio BOND showing significant in vitro toxicity while the other three did not exhibit significant toxic effects towards SC cell line. In vitro toxicity assessment should be considered prior to in vivo and clinical studies, and flow cytometry can enhance research accuracy and should be incorporated into standardization criteria.
Article
Metallurgy & Metallurgical Engineering
Jun-xiu Chen, Yang Yang, Iniobong P. Etim, Li -li Tan, Ke Yang, R. D. K. Misra, Jian-hua Wang, Xu-ping Su
Summary: The addition of nano-Y2O3 to micro-arc oxidation coating on magnesium alloys improves the wear resistance and degradation resistance. The nano-Y2O3 particles stabilize the coating and seal the micro-pores, resulting in improved coating properties. The degradation rate and volume loss of the coating are significantly reduced.
TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA
(2023)
Article
Cell & Tissue Engineering
M. G. Wiesli, J-P Kaiser, E. Gautier, P. Wick, K. Maniura-Weber, M. Rottmar, P. Wahl
Summary: The study found that ceftriaxone has a dose-dependent cytotoxic effect on human bone progenitor cells. It is recommended to keep the concentration of ceftriaxone below 250 mg/l when locally applied to reduce the risk of poor osseointegration of prosthetic implants.
BONE & JOINT RESEARCH
(2021)
