期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 100B, 期 7, 页码 1989-2014出版社
WILEY
DOI: 10.1002/jbm.b.32772
关键词
stents; cardiovascular; biocompatibility; surface modification; cell-material interactions
资金
- National Biophotonics and Imaging Platform, Ireland
- Irish Government's Programme for Research in Third Level Institutions, Cycle 4
- Ireland's EU Structural Funds Programmes
- Competence Centre for Applied Nanotechnology
- Science Foundation Ireland and Health Research Board
- Natural Sciences and Engineering Research Council of Canada
Coronary artery disease (CAD) kills millions of people every year. It results from a narrowing of the arteries (stenosis) supplying blood to the heart. This review discusses the merits and limitations of balloon angioplasty and stent implantation, the most common treatment options for CAD, and the pathophysiology associated with these treatments. The focus of the review is heavily placed on research efforts geared toward the modification of stent surfaces for the improvement of stent-vascular compatibility and the reduction in the occurrence of related pathophysiologies. Such modifications may be chemical or physical, both of which are surveyed here. Chemical modifications may be passive or active, while physical modification of stent surfaces can also provide suitable substrates to manipulate the responses of vascular cells (endothelial, smooth muscle, and fibroblast). The influence of micro- and nanostructured surfaces on the in vitro cell response is discussed. Finally, future perspectives on the combination of chemical and physical modifications of stent surfaces are also presented. (C) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
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