Article
Engineering, Biomedical
Ziv Azoulay, Polina Aibinder, Ayala Gancz, Jacob Moran-Gilad, Shiri Navon-Venezia, Hanna Rapaport
Summary: FKF, a tripeptide with potential antimicrobial activity, forms a pure peptide hydrogel phase made of natural amino acids. The hydrogel exhibits bactericidal activity against E. coli and P. aeruginosa, and reduces P. aeruginosa contamination in a rat skin lesion model.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Jingjing Zhou, Ruitao Cha, Zhiyu Wu, Chunliang Zhang, Yuhang He, Hanru Zhang, Kexin Liu, Muhammad Subaan Fareed, Zhaopeng Wang, Changyan Yang, Yifan Zhang, Wenjin Yan, Kairong Wang
Summary: In this study, a peptide hydrogel formed by natural antimicrobial peptide Jelleine-1 was reported and its potential use for MRSA-infected wounds was investigated. The results showed that the Jelleine-1 hydrogel exhibited broad spectrum of antimicrobial activity, excellent biocompatibility, and great potential in promoting wound healing in a mouse model with MRSA-infected burn wound.
Article
Chemistry, Applied
Huimin Chen, Tianrui Zhang, Yongqi Tian, Lijun You, Yan Huang, Shaoyun Wang
Summary: This study provides insights into the mechanism of peptide gelation, offering a way to control self-assembly behaviors and achieve a variety of nanostructures. The peptide assembly process involves five stages and is highly influenced by the charging status of terminal groups. Additionally, the successful loading of curcumin into different self-assembly nanostructures demonstrates high encapsulation efficiency and effective protection.
FOOD HYDROCOLLOIDS
(2022)
Review
Biotechnology & Applied Microbiology
Kun Fu, Hanguang Wu, Zhiqiang Su
Summary: The hierarchical formation of self-assembling peptide-based hydrogels (SAPHs) starts from peptide to nanofibers, forming hydrogels with nanofibrous network, which possess unique structure, exceptional biocompatibility, and diverse applications. This review introduces the fabrication, properties, and biological applications of SAPHs, along with systematic explanations on factors influencing synthesis process and properties of SAPHs products. The review also highlights current challenges and offers perspectives on future development of SAPHs in biotechnology.
BIOTECHNOLOGY ADVANCES
(2021)
Article
Biotechnology & Applied Microbiology
Yang Wang, Xiao Li, Juzheng Yuan, Xudan Wang, Kaishan Tao, Jin Yan
Summary: In this study, an injectable hydrogel with hemostatic and bactericidal function based on Bionic Self-Assembling Peptide (BSAP) was developed. The hydrogel showed rapid formation of a network structure in vivo and exhibited excellent physicochemical properties. It effectively reduced blood clotting time and bleeding volume, and also reduced inflammatory responses by blocking bacterial infection and promoting wound healing. The results provide a strategy for developing a high-biosecurity hydrogel with hemostatic and antibacterial properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Priyadarshi Chakraborty, Moran Aviv, Francesca Netti, Dana Cohen-Gerassi, Lihi Adler-Abramovich
Summary: Co-assembly of two different building blocks can harness both of their attributes and produce nanostructured macro-scale objects with improved physical properties and desired functional complexity.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Fang-Yi Wu, Hsin-Chieh Lin
Summary: Synthetic bioactive aromatic peptide amphiphiles are recognized as key elements of emerging biomedical strategies due to their biocompatibility, design flexibility, and functionality. We investigated the self-assembly driving force of two supramolecular materials and found ordered π-π interactions and secondary structures in both compounds. In cell experiments, PFB-IKVAV showed promise as a potential supramolecular biomaterial for biomedical applications.
Review
Chemistry, Multidisciplinary
Liangchun Li, Li Xie, Renlin Zheng, Rongqin Sun
Summary: This review discusses the design and structures of self-assembly linear dipeptide hydrogels, as well as the strategies for preparing the new generation of hydrogels. With a deeper understanding of the relationship between the structures and properties of dipeptides, it is believed that dipeptide hydrogels have great potential in preparing minimal biocompatible materials.
FRONTIERS IN CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Naoki Tsutsumi, Akitaka Ito, Azumi Ishigamori, Masato Ikeda, Masayuki Izumi, Rika Ochi
Summary: In this study, a novel bola-amphiphilic glycosylated lipopeptide-type supramolecular hydrogelator is presented, exhibiting reversible thermochromism and gel-sol transition. The investigation focused on the effects of different numbers of F residues on gelation ability and morphology of self-assembled nanostructures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Gal Yosefi, Nitsan Eliraz, Sofiya Kolusheva, Hanna Rapaport, Ronit Bitton
Summary: This study reports on the formation and characterization of self-assembled membranes made with & lambda;-carrageenan and cationic & beta;-sheet peptides. The results show that the polysaccharide conformation, solution viscosity, and interactions between polysaccharides and peptides affect the properties of the membranes. The interplay between polymer-peptide interactions and polysaccharide chain stiffness could be used to control the structure-function relationship of the membranes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Xuejiao Yang, Honglei Lu, Yinghua Tao, Hongyue Zhang, Huaimin Wang
Summary: This study reports a method to control the fiber alignment, chirality, and stiffness of aromatic peptide hydrogels through heterodimerization of enantiomeric mixtures. The relative ratio of L and D enantiomers can also regulate the adhesion and morphology of mammalian cells. This work provides a new strategy for controlling supramolecular chirality in materials science.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yanxin Xiang, Can Liu, Shinan Ma, Xiaoting Wang, Linyong Zhu, Chunyan Bao
Summary: In this study, a pH-responsive peptide (MA-FIID) is designed and introduced into a poly(N-isopropyl acrylamide) backbone (PNIPAM) to construct bilayer and heterogeneous hydrogel actuators based on the assembly and disassembly of peptide molecules under different pH conditions. These peptide-containing hydrogel actuators can perform controllable bending, bucking, and complex deformation under pH stimulation. Meanwhile, the Hofmeister effect of PNIPAM hydrogels endows these peptide-containing hydrogels with enhanced mechanical strength, ionic stimulus response (CaCl2), and excellent shape-memory property.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Ting Li, Caihong Shi, Zhenan Mi, Hongjia Xu, Jinghua Xu, Linlin Wang, Xiangrong Zhang
Summary: This article explores the application of peptide self-assemble hydrogels as drug delivery vehicles. The network structure of the hydrogel and its interaction with puerarin were analyzed. The study found that the hydrogel can effectively release puerarin and has a positive effect on treating osteoarthritis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Polymer Science
Alexandra Lupu, Luiza Madalina Gradinaru, Vasile Robert Gradinaru, Maria Bercea
Summary: Hydrogels are three-dimensional networks that can absorb large amounts of water or biological fluids, release active compounds in a controlled manner, and be sensitive to external stimuli. This paper discusses the advantages of incorporating biomolecules (polysaccharides, proteins, and polypeptides) into hydrogels, emphasizing their structural aspects and specific properties. The suitable applications, including drug delivery, regenerative medicine, cell culture, wound dressings, 3D bioprinting, and food, are highlighted.
Article
Materials Science, Biomaterials
Alessia Ajovalasit, Carlos Redondo-Gomez, Maria Antonietta Sabatino, Babatunde O. Okesola, Kristin Braun, Alvaro Mata, Clelia Dispenza
Summary: This work presents a self-assembling hydrogel dressing that mimics the hierarchical structure of skin extracellular matrix by investigating the co-assembly behavior of a carboxylated variant of xyloglucan (CXG) with a peptide amphiphile (PA-H3) to generate hierarchical constructs with tuneable molecular composition, structure, and properties. The hydrogel dressing is characterized by its morphology and mechanical properties, and a preliminary biological evaluation has been carried out both in vitro with HaCat cells and in vivo in a mouse model.
REGENERATIVE BIOMATERIALS
(2021)
