期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 91B, 期 1, 页码 181-190出版社
WILEY
DOI: 10.1002/jbm.b.31388
关键词
gelatin; poly(D,L-lactide); hydroxyapatite; nanofibers; biomineralization
资金
- National Natural Science Foundation of China [50773065]
- Ministry of Education of China [NCET-07-0719]
- Sichuan Prominent Young Talent Program [08ZQ026-040]
A novel biodegradable polymer-ceramic nanocomposite was prepared using the in situ preparation method, which consisted of gelatin (gel), poly (D,L-lactide) (PDLLA), and hydroxyapatite (HA) nanofibers. In this article, the HA nanofibers with length/diameter (L/D) ratio of 19.8 in gel/PDLLA/HA nanocomposites were synthesized and precipitated in polymeric matrix by one-step hydrothermal mineralization. The crystalline phases, structural morphology, mechanical characterization, and chemical interaction of gel/PDLLA/HA nanocomposites were investigated by X-ray diffraction, transmission electron microscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, mechanical test, and Fourier transform infrared spectroscopy. The results showed that the crystalline HA nanofibers were uniformly mineralized in gel and PDLLA matrix and the interaction between Ca2+ in HA (nanofibers and negative-charged functional groups in gel and PDLLA molecular chains was formed. Thus, the schematic model of two polymeric chains bridged by inorganic nanofibers was designed on the basis of the experimental results. Moreover, it can clearly explain why the mechanical properties of gel/PDLLA/HA nanocomposites turned strong. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 91B: 181-190, 2009
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