期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 88B, 期 1, 页码 250-253出版社
WILEY
DOI: 10.1002/jbm.b.31175
关键词
murine model; continuous infusion; particles
资金
- NIH [R21 AR053189-01]
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR055650, R21AR053189] Funding Source: NIH RePORTER
Continued production of wear debris affects both initial osseointegration and subsequent bone remodeling of total joint replacements (TJRs). However, continuous delivery of clinically relevant particles using a viable, cost effective, quantitative animal model to simulate the scenario in humans has been a challenge for orthopedic researchers. In this study, we successfully infused blue-dyed polystyrene particles, similar in size to wear debris in humans, to the intramedullary space of the mouse femur for 4 weeks using an osmotic pump. Approximately 40% of the original particle load (85 mu L) was delivered into the intramedullary space, an estimate of 3 X 109 particles. The visible blue dye carried by the particles confirmed the delivery. This model demonstrated that continuous infusion of particles to the murine bone-implant interface is possible. In vivo biological processes associated using wear debris particles can be studied using this new animal model. (C) 2008 Wiley Periodicals. Inc. J Biomed Mater Res Part B: Appl Biomater 88B: 250-253, 2009
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