Article
Chemistry, Applied
Sihan Zhang, Guanglei Zhao, Wei Ma, Yanghui Song, Cheng Huang, Chong Xie, Kebing Chen, Xiaofeng Li
Summary: A porous chitosan nanofiber scaffold (CSNFS) with an extracellular matrix-like structure was prepared through a cross-linking reaction, showing high porosity and adequate micro-scale pores. CSNFS has good mechanical strength and biocompatibility, and can be used as a repair material for bone tissue engineering.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Xing Fu, Qian-cheng Zhao, Dong Uk Ahn, Mei-hu Ma, Xi Huang
Summary: This study developed biomineralization scaffolds using eggshell membranes as the bio-template, which showed better mineralization potential and cell adhesion ability after enzyme treatment.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Hsu-Hsiang Lin, Pen-Hsiu Grace Chao, Wei-Chiu Tai, Po-Chun Chang
Summary: This study successfully developed a biomimetic microfibrous system to assist PDL regeneration and withstand functional load. Collagen-based microfibers were fabricated and PDL cells seeded on waveform microfibers showed enhanced growth and gene expression levels, indicating potential for promoting healing and regeneration under shear stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Ji Min Seok, Goeun Choe, Sang Jin Lee, Min-Ah Yoon, Kwang-Seop Kim, Jun Hee Lee, Wan Doo Kim, Jae Young Lee, Kangwon Lee, Su A. Park
Summary: The study demonstrates that using an ecofriendly mussel-inspired GO coating can effectively enhance the functionality and bioactivity of 3D-printed scaffolds. By regulating the amount of GO deposition and employing a non-toxic coating method, the surface properties are improved, aiding in promoting osteogenesis.
MATERIALS & DESIGN
(2021)
Article
Engineering, Biomedical
Wei Chen, Yongsheng Li, Yuting Huang, Yao Dai, Tingfei Xi, Zheng Zhou, Hairong Liu
Summary: The study indicates that quercetin-modified PHBV fibrous scaffold has the potential to promote cartilage regeneration in tissue engineering. By regulating related genes, it can inhibit chondrocyte apoptosis and reduce oxidative stress.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Review
Polymer Science
Antony V. V. Samrot, Mahendran Sathiyasree, Sadiq Batcha Abdul Rahim, Robinson Emilin Renitta, Kasirajan Kasipandian, Sivasuriyan Krithika Shree, Deenadhayalan Rajalakshmi, Nagarajan Shobana, Shanmugaboopathi Dhiva, Sasi Abirami, Sridevi Visvanathan, Basanta Kumar Mohanty, Gokul Shankar Sabesan, Suresh V. Chinni
Summary: Biological macromolecules, such as polysaccharides, proteins, and glycoproteins, have been widely used in tissue engineering due to their ability to mimic the extracellular matrix and their biocompatibility. Scaffolds made from these macromolecules have properties like tensile strength, biodegradability, and flexibility. This review discusses the fabrication methods and applications of scaffolds using various biological macromolecules and emphasizes the importance of natural polymers over synthetic ones due to their unique properties.
Article
Chemistry, Multidisciplinary
A. Dadashzadeh, S. Moghassemi, C. A. Amorim
Summary: This study demonstrated that PEGylated fibrin hydrogels enhanced scaffold stability, supported cell viability and proliferation. PEG:Fib 5:1 T50 showed a significantly higher cell density dynamic and a lower expression of caspase-3. In contrast, PEG:Fib 10:1 T50 hydrogels had uniform cell distribution and a higher rate of Ki67-positive cells.
MATERIALS TODAY CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Akbar Teguh Prakoso, Hasan Basri, Dendy Adanta, Irsyadi Yani, Muhammad Imam Ammarullah, Imam Akbar, Farah Amira Ghazali, Ardiyansyah Syahrom, Tunku Kamarul
Summary: Permeability is an important factor to consider in the design of porous scaffolds for cell migration and bone tissue regeneration. This study developed a porous scaffold based on the morphological indices of cancellous bone and analyzed fluid flow through the scaffold using computational fluid dynamics. The permeability of the scaffold was compared to that of natural cancellous bone and different scaffold types. The results showed that the Negative Schwarz Primitive (NSP) scaffold had similar permeability to natural cancellous bone and could be manipulated by changing the curvature to support cell migration and tissue regeneration.
Article
Biophysics
Jian He, Zhidong Lin, Xulin Hu, Luyao Xing, Gaofeng Lian, Dongliang Chen, Junling An, Chengdong Xiong, Xiangchun Zhang, Lifang Zhang
Summary: The study developed bioactive scaffolds with favorable mechanical properties and osteogenesis promotion, which could be a promising alternative to bone cement in bone tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Mohammad Zamanifard, Mohammad Taghi Khorasani, Morteza Daliri
Summary: Despite the complexities of treatment for central nervous system injuries, this study developed a promising scaffold for nerve tissue engineering. Natural polyhydroxybutyrate and gelatin were used to create the scaffold, which was modified through exposure to ammonium gas plasma and coating with laminin and polyaniline nanoparticles. The modified scaffold showed improved properties, including decreased contact angle, increased residual weight, higher modulus, increased cell viability, and enhanced cell adhesion. This scaffold has potential applications in the treatment of central nervous system disorders.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Dana Jenkins, Karim Salhadar, Grant Ashby, Anita Mishra, Joy Cheshire, Felipe Beltran, Melissa Grunlan, Sebastien Andrieux, Cosima Stubenrauch, Elizabeth Cosgriff-Hernandez
Summary: The pore size of a scaffold has significant effects on various physical properties in tissue engineering. Manual measurements using ImageJ/FIJI are time-consuming and subjective. In this study, a new MATLAB algorithm called PoreScript was developed and validated using different scaffold fabrication methods. The results demonstrate the accuracy and versatility of PoreScript.
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Matthew McGrath, Karolina Zimkowska, Katelyn J. Genoud, Jack Maughan, Javier Gutierrez Gonzalez, Shane Browne, Fergal J. O'Brien
Summary: A biomimetic, bilayered antimicrobial collagen-based scaffold was developed to deal with the etiology of diabetic foot ulcers (DFUs). The scaffold exhibited high structural stability, successfully inhibited the growth and infiltration of Staphylococcus aureus, and supported the proliferation of epidermal cells and vascularization. These results suggest that the bilayered scaffold is a promising candidate for enhancing diabetic wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Ophthalmology
Kanika Bhardwaj, Uma Sridhar
Summary: The shortage of donor corneal tissue has prompted research on tissue engineering methods to create alternatives. In this study, a biodegradable scaffold was developed using a mixture of PDLLA and Eudragit polymers. The scaffold showed stability, porosity, and water retention capacity, making it suitable for in vitro growth of corneal epithelial stem cells. The scaffold made with a 70:30 ratio of PDLLA to Eudragit was found to promote the growth of laboratory corneal epithelial stem cells.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Panneerselvam Jithendra, Jamal Moideen Muthu Mohamed, Dinesh Annamalai, Rasha Hamed Al-Serwi, Ateya Megahed Ibrahim, Mohamed El-Sherbiny, Abraham Merlin Rajam, Mamdouh Eldesoqui, Nimer Mansour
Summary: The chondrogenic efficacy of aloe vera blended collagen-chitosan (COL-CS-AV) porous scaffold was investigated using articular chondrocytes. The scaffold showed higher chondrogenic efficacy compared to COL-CS, making it a suitable candidate for cartilage tissue engineering. The study utilized various assays and staining techniques to analyze cytocompatibility, GAG content, RNA content, and expression of cartilage-specific genes and collagen type II.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Xinshuai Gao, Honghua Wang, Shifang Luan, Guangyuan Zhou
Summary: This article introduces a new polymer material, PAEK-COOH, which is synthesized and fabricated into hierarchically controllable porous scaffolds via low-temperature 3D printing. The prepared scaffolds exhibit comparable mechanical strength to trabecular bone and the nanoporous surface promotes cellular adhesion and hydroxyapatite mineralization through electrostatic interaction. In vivo experiments demonstrate the superior osseointegration of the PAEK-COOH scaffolds compared to PEEK, without the need for additional active ingredients.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Agricultural Engineering
Zhiyuan Liu, Yunxin Zhu, Chenyu Zhao, Cheng Zhang, Jie Ming, Aditya Sharma, Guoping Chen, Yingnan Yang
Summary: A light stimulation strategy was investigated to promote bio-H-2 production. The optimal light condition increased H-2 yield and promoted efficient H-2 producing pathway. The microbial community was also affected by light stimulation. Long-term operation showed higher and more stable H-2 production in the light stimulated bioreactor.
BIORESOURCE TECHNOLOGY
(2022)
Article
Engineering, Environmental
Cheng Zhang, Na Liu, Jie Ming, Aditya Sharma, Qiansu Ma, Zhiyuan Liu, Guoping Chen, Yingnan Yang
Summary: The novel Linear fresnel photoreactor (LFP) developed in this study optimizes sunlight for wastewater treatment by flexibly controlling mirrors according to solar position and weather conditions. This reactor shows great potential in improving wastewater treatment efficiency in densely populated areas through effective adjustment of light irradiance and temperature.
Article
Materials Science, Biomaterials
Linawati Sutrisno, Huajian Chen, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: The study developed a bifunctional PLGA-collagen-BPNS composite scaffold with high mechanical strength, photothermal ablation capability, and promotion of skin tissue regeneration.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Yongtao Wang, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: This study investigates the impact of cell density on gene transfection of mesenchymal stem cells. It shows that moderate cell density is beneficial for gene transfection, while low and high cell densities have negative effects. The influence of cell density on gene transfection is strongly correlated with its effect on cellular uptake capacity and DNA synthesis.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Engineering, Biomedical
Yan Xie, Linawati Sutrisno, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: Interconnected scaffolds promote the chondrogenic differentiation of stem cells. In this study, collagen scaffolds with interconnected pore structures were fabricated using PLGA sponge templates and were used to culture human bone marrow-derived mesenchymal stem cells (hMSCs). The results showed that the interconnected scaffolds can enhance the chondrogenic differentiation of stem cells and improve the production of cartilaginous matrices and the mechanical properties of the implants after subcutaneous implantation.
BIOMEDICAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Yoshiki Komatsu, Toru Yoshitomi, Kinji Furuya, Takafumi Ikeda, Azusa Terasaki, Aoi Hoshi, Naoki Kawazoe, Guoping Chen, Hirofumi Matsui
Summary: A tissue-adhesive porphyrin with polycations has been developed in this study, which can effectively mark tissues during laparoscopic surgery. This is a promising technique for tumor localization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Jie Ming, Xiang Sun, Qiansu Ma, Na Liu, Cheng Zhang, Naoki Kawazoe, Guoping Chen, Yingnan Yang
Summary: Pathogenic contamination is a major cause of clean water shortage and poses a risk to human health. This study introduced g-C3N4 (CN) into Ag/Ag2O/BiPO4/Bi2WO6 (Ag/P/BWO) to construct a novel composite CN-Ag/P/BWO for disinfecting Enterococcus sp. contaminated water. The composite showed excellent disinfection performance under simulated solar light irradiation, attributed to improved light absorption ability, charge carries separation/transfer efficiency, and surface wettability. The disinfection mechanism involved photogenerated active species working together and damaging bacterial cells. The composite also exhibited high practicability and stability for different environmental factors and real lake water disinfection, providing an efficient method for water disinfection.
Article
Materials Science, Biomaterials
Huajian Chen, Rui Sun, Tianjiao Zeng, Jing Zheng, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: This study developed a smart platform for stepwise photothermal therapy (PTT) and chemotherapy, which effectively achieved synergistic effects of PTT and chemotherapy while minimizing damage to normal cells. The temperature and drug release from the composite scaffolds could be controlled, allowing for high local temperatures during PTT and controlled drug release during chemotherapy. In vitro and in vivo experiments demonstrated the strong synergistic effect of the combined therapy, with a mild hyperthermia effect after degradation of black phosphorus (BP). Additionally, the composite scaffolds supported the proliferation of mesenchymal stem cells after complete drug release.
BIOMATERIALS SCIENCE
(2022)
Article
Materials Science, Biomaterials
Huajian Chen, Rui Sun, Jing Zheng, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: Synergistic photothermal therapy and chemotherapy using a smart platform was developed for breast cancer treatment, which effectively eliminated cancer cells in the early stage and promoted stem cell activities in the late stage.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Jing Zheng, Yongtao Wang, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: This study investigated the effects of cell culture medium viscosity on the differentiation of hMSCs with controlled cell morphology using micropatterns. The results showed that viscosity could influence the osteogenic and adipogenic differentiation of hMSCs, and this effect was dependent on cell morphology.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Multidisciplinary
Yan Xie, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: The study introduced a new method for preparing collagen scaffolds using synthetic PLGA mesh as a template, resulting in different structures of collagen meshes that supported cell adhesion and proliferation. Among them, collagen mesh-S showed superior promotive effects, aiding in dermal tissue regeneration.
MATERIALS ADVANCES
(2022)