Article
Cell Biology
Wenxin Tang, Chaoying Yan, Shuxuan He, Mengyu Du, Bo Cheng, Bin Deng, Shan Zhu, Yansong Li, Qiang Wang
Summary: Type 2 diabetes mellitus can lead to cognitive dysfunction due to mitochondrial dysfunction. Excessive mitochondrial fission and impaired mitophagy result in altered mitochondrial morphology and dysfunction, leading to neuronal damage. Cav-1 expression and function can improve this cognitive dysfunction.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Mineh Markarian, Robert P. Krattli, Jabra D. Baddour, Leila Alikhani, Erich Giedzinski, Manal T. Usmani, Anshu Agrawal, Janet Elizabeth Baulch, Andrea J. Tenner, Munjal M. Acharya
Summary: Recent research has shown that radiotherapy can lead to neuroinflammation and cognitive impairments in the brain, but genetic knockdown of C1q in a mouse model can alleviate these adverse effects.
Article
Biochemistry & Molecular Biology
Amanda J. Croft, Conagh Kelly, Dongqing Chen, Tatt Jhong Haw, Aaron L. Sverdlov, Doan T. M. Ngo
Summary: Obesity is associated with various metabolic disorders and cardiovascular diseases, causing increased hospitalizations, morbidity, and mortality. Dysfunction of adipose tissue due to chronic nutrient stress can lead to oxidative stress, mitochondrial dysfunction, inflammation, hypoxia, and insulin resistance. This study aimed to reduce adipose tissue oxidative stress by overexpressing the antioxidant mitochondrial catalase (mCAT) in adipose tissue to improve systemic metabolic function. The results showed that the AdipoQ-mCAT mice were protected from further metabolic impairment under obesogenic dietary conditions compared to obese wild-type mice, highlighting the critical role of physiological H2O2 signaling in metabolism and adipose tissue function.
Article
Biochemistry & Molecular Biology
Cheng-Wei Lu, Tzu-Yu Lin, Tai-Long Pan, Pei-Wen Wang, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang
Summary: Asiatic acid alleviates seizures and improves cognitive impairment in KA-treated rats by inhibiting calpain activation, increasing AKT activation, and enhancing synaptic and mitochondrial function.
Article
Biochemistry & Molecular Biology
Annett Eitner, Sylvia Mueller, Christian Koenig, Arne Wilharm, Rebecca Raab, Gunther O. Hofmann, Thomas Kamradt, Hans-Georg Schaible
Summary: IL-1 beta induces NO release and mitochondrial dysfunction, and both can be prevented by inhibiting iNOS with L-NIL. Additionally, enhancing cAMP or inhibiting AMPK can reduce the effects of IL-1 beta, preventing NO release and mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Abhishek Chandra, Anthony B. Lagnado, Joshua N. Farr, Madison Doolittle, Tamara Tchkonia, James L. Kirkland, Nathan K. LeBrasseur, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Joao F. Passos, David G. Monroe, Robert J. Pignolo, Sundeep Khosla
Summary: This study demonstrates that cellular senescence-driven radiation-induced osteoporosis is primarily mediated by p21(Cip1) rather than p16(Ink4a), based on the clearance of senescent cells using genetic models. This approach may be used to investigate the contributions of these pathways in other senescence-associated conditions, including aging across tissues.
Article
Neurosciences
Caroline Bitencourt Soares, Leticia Rossi Dare, Karine Ramires Lima, Luiza Freitas Lopes, Alexandre Garcia Dos Santos, Helen Lidiane Schimidt, Felipe Pivetta Carpes, Ana Lloret, Jose Vina, Pamela Billig Mello-Carpes
Summary: The study found that long-term multicomponent exercise training can prevent amyloid-beta neurotoxicity in the hippocampus, reducing oxidative stress, restoring antioxidant capacity, increasing glutathione levels, and ultimately preventing recognition memory deficits.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Francisca Villavicencio-Tejo, Margrethe A. Olesen, Alejandra Aranguiz, Rodrigo A. Quintanilla
Summary: Alzheimer's disease is characterized by memory and cognitive impairment, with the accumulation of amyloid beta-peptide and the presence of pathological forms of tau protein. Activation of the Nrf2 pathway has been found to protect against mitochondrial injury induced by pathological tau protein.
Article
Biochemistry & Molecular Biology
Susanne Flor, Claudia R. Oliva, Md Yousuf Ali, Kristen L. Coleman, Jeremy D. Greenlee, Karra A. Jones, Varun Monga, Corinne E. Griguer
Summary: Glioblastoma, the deadliest form of brain cancer, often becomes resistant to standard treatments due to the upregulation of antioxidant catalase (CAT) which enhances resistance to chemotherapy and radiation, decreases survival rates, and enriches glioma stem cell populations.
Article
Oncology
Saryleine Ortiz de Choudens, Rodney Sparapani, Jayashree Narayanan, Nicole Lohr, Feng Gao, Brian L. Fish, Monika Zielonka, Tracy Gasperetti, Dana Veley, Andreas Beyer, Jessica Olson, Elizabeth R. Jacobs, Meetha Medhora
Summary: This study observed the effects of radiation therapy on rats and found that it caused heart damage, with SS rats being more susceptible to mitochondrial dysfunction. Lisinopril helped mitigate the damage, independent of genetic background.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Biomedical
Zhaoyu Ma, Heyou Han, Yanli Zhao
Summary: Mitochondria play critical roles in regulating the proliferation and apoptosis of cancer cells. Targeted induction of mitochondrial dysfunction in cancer cells by multifunctional nanosystems has attracted increasing attention in recent years. Understanding the mechanisms of mitochondrial dysfunction is important for efficient disease treatment and translating therapeutic strategies into the clinic.
Article
Neurosciences
Afzal Misrani, Sidra Tabassum, Zai-yong Zhang, Shao-hua Tan, Cheng Long
Summary: The study found that urolithin A (UA) can reduce neuroinflammation and improve mitochondrial health, showing therapeutic effects in a sleep deprivation mouse model.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xuyun Liu, Jing Gao, Yizhen Yan, Eleftheria A. A. Georgiou, Jing Lou, Mengya Feng, Xing Zhang, Feng Gao, Jiankang Liu, Ioannis K. K. Kostakis, Lin Zhao
Summary: Mitochondria-targeted TPP-HT prevents lipotoxicity-induced endothelial dysfunction by enhancing mitochondrial function and redox balance through promoting FoxO1 and Nrf2 nuclear translocation.
Review
Pharmacology & Pharmacy
Tanzeel Khan, Rashid Waseem, Zainy Zehra, Ayesha Aiman, Priyanka Bhardwaj, Jaoud Ansari, Md. Imtaiyaz Hassan, Asimul Islam
Summary: Mitochondria are essential organelles involved in various cellular functions, and their dysfunction can lead to the development of various diseases. Targeted drug delivery to mitochondria has become a promising strategy for the diagnosis, treatment, and prevention of diseases. Recent advancements in nanoformulations, such as polymeric nanoparticles and liposomes, have shown potential in overcoming the challenges associated with delivering therapeutic molecules to the mitochondria.
Article
Biology
Nastaran Daneshgar, Andrew W. Baguley, Peir-In Liang, Fei Wu, Yi Chu, Michael T. Kinter, Gloria A. Benavides, Michelle S. Johnson, Victor Darley-Usmar, Jianhua Zhang, Kung-Sik Chan, Dao-Fu Dai
Summary: Investigation of mitochondrial dysfunction in ADPKD and potential therapeutic agents suggests that overexpression of mCAT or treatment with SS31 may slow cystogenesis by targeting oxidative stress and mitochondrial dysfunction.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Sarah M. Smith, Erich Giedzinski, Maria C. Angulo, Tiffany Lui, Celine Lu, Audrey L. Park, Sharon Tang, Vahan Martirosian, Ning Ru, Nicole N. Chmielewski, Yaxuan Liang, Janet E. Baulch, Munjal M. Acharya, Charles L. Limoli
STEM CELLS TRANSLATIONAL MEDICINE
(2020)
Review
Neurosciences
Adam D. Bachstetter, Josh M. Morganti, Colleen N. Bodnar, Scott J. Webster, Emma K. Higgins, Kelly N. Roberts, Henry Snider, Shelby E. Meier, Grant K. Nation, Danielle S. Goulding, Matthew Hamm, David K. Powell, Moriel Vandsburger, Linda J. Van Eldik, Jose F. Abisambra
EXPERIMENTAL NEUROLOGY
(2020)
Review
Biochemistry & Molecular Biology
Yong Qin Koh, Chia Jie Tan, Yi Long Toh, Siu Kwan Sze, Han Kiat Ho, Charles L. Limoli, Alexandre Chan
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Immunology
Barrett D. Allen, Amber Syage, Mattia Maroso, Al Anoud D. Baddour, Valerie Luong, Harutyun Minasyan, Erich Giedzinski, Brian L. West, Ivan Soltesz, Charles L. Limoli, Janet E. Baulch, Munjal M. Acharya
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Immunology
Alexandria N. Early, Amy A. Gorman, Linda J. Van Eldik, Adam D. Bachstetter, Josh M. Morganti
JOURNAL OF NEUROINFLAMMATION
(2020)
Review
Chemistry, Medicinal
Bellamkonda Bosebabu, Sri Pragnya Cheruku, Mallikarjuna Rao Chamallamudi, Madhavan Nampoothiri, Rekha R. Shenoy, Krishnadas Nandakumar, Vipan K. Parihar, Nitesh Kumar
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2020)
Article
Oncology
Yasaman Alaghband, Samantha N. Cheeks, Barrett D. Allen, Pierre Montay-Gruel, Ngoc-Lien Doan, Benoit Petit, Patrik Goncalves Jorge, Erich Giedzinski, Munjal M. Acharya, Marie-Catherine Vozenin, Charles L. Limoli
Review
Oncology
Gajalakshmi Ramanathan, Brianna M. Hoover, Angela G. Fleischman
Article
Oncology
Gajalakshmi Ramanathan, Brianna Craver-Hoover, Rebecca J. Arechavala, David A. Herman, Jane H. Chen, Hew Yeng Lai, Samantha R. Renusch, Michael T. Kleinman, Angela G. Fleischman
Article
Medicine, Research & Experimental
Vaishali Jayashankar, Elizabeth Selwan, Sarah E. Hancock, Amandine Verlande, Maggie O. Goodson, Kazumi H. Eckenstein, Giedre Milinkeviciute, Brianna M. Hoover, Bin Chen, Angela G. Fleischman, Karina S. Cramer, Stephen Hanessian, Selma Masri, Nigel Turner, Aimee L. Edinger
Summary: Compounds targeting mitochondrial dynamics are ineffective at blocking ceramide-induced fission, while targeting endolysosomal trafficking events can rapidly and effectively prevent disruptions in mitochondrial form and function caused by ceramide.
EMBO MOLECULAR MEDICINE
(2021)
Article
Oncology
Nicole Chmielewski-Stivers, Benoit Petit, Jonathan Ollivier, Virginie Monceau, Pelagia Tsoutsou, Ana Quintela Pousa, Xiaomeng Lin, Charles Limoli, Marie-Catherine Vozenin
Summary: This study identified sex- and organ-specific responses to systemic paclitaxel administration and localized radiotherapy, with female mice showing protection against neurotoxicity and cardiotoxicity compared to males. RhoB was revealed as a molecular determinant driving estrogen-dependent cardioprotection in female mice.
Review
Oncology
Nicole N. Chmielewski, Charles L. Limoli
Summary: This review explores the sex-specific mechanisms of action and clinical outcomes in taxane drug toxicity, providing a novel framework to investigate common sex differences observed in clinical and pre-clinical research. It also highlights the importance of studying taxane-induced sex-specific mechanisms and toxicities to improve cancer treatment outcomes.
Article
Oncology
Charles L. Limoli, Eniko A. Kramar, Aymeric Almeida, Benoit Petit, Veljko Grilj, Janet E. Baulch, Paola Ballesteros-Zebadua, Billy W. Loo Jr, Marcelo A. Wood, Marie -Catherine Vozenin
Summary: Long-term potentiation (LTP) was used to assess the effects of conventional and FLASH dose rates on synaptic transmission. The findings showed that after 10 fractions of 3 Gy conventional radiotherapy, LTP was significantly inhibited. However, both 10x3Gy FLASH radiotherapy and the control group exhibited normal LTP.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Brianna M. Craver, Thanh Kim Nguyen, Jenny Nguyen, Hellen Nguyen, Christy Huynh, Sarah J. Morse, Angela G. Fleischman
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2020)
Article
Hematology
Brianna M. Craver, Gajalakshmi Ramanathan, Summer Hoang, Xinyue Chang, Laura F. Mendez Luque, Stefan Brooks, Hew Yeng Lai, Angela G. Fleischman