Orthopedic implant cobalt-alloy particles produce greater toxicity and inflammatory cytokines than titanium alloy and zirconium alloy-based particles in vitro, in human osteoblasts, fibroblasts, and macrophages

Danger Signaling through the Inflammasome Acts as a Master Switch between Tolerance and Sensitization

(2014) Hideki Watanabe et al.   JOURNAL OF IMMUNOLOGY

Pseudotumor With Dominant B-Lymphocyte Infiltration After Metal-On-Metal Total Hip Arthroplasty With a Modular Cup

(2011) Masahiro Hasegawa et al.   JOURNAL OF ARTHROPLASTY

Micrometer-Sized Titanium Particles Can Induce Potent Th2-Type Responses through TLR4-Independent Pathways

(2011) P. K. Mishra et al.   JOURNAL OF IMMUNOLOGY

Characterization of metal-wear nanoparticles in pseudotumor following metal-on-metal hip resurfacing

(2011) Zhidao Xia et al.   Nanomedicine-Nanotechnology Biology and Medicine

An In Vitro Assessment of Wear Particulate Generated From NUBAC

(2011) Tim Brown et al.   SPINE

Early Failure of Metal-on-Metal Artificial Disc Prostheses Associated with Lymphocytic Reaction

(2011) Richard D. Guyer et al.   SPINE

In vitro and in vivo evaluation of an alumina–zirconia composite for arthroplasty applications

(2010) Olivier Roualdes et al.   BIOMATERIALS

The in vitro genotoxicity of orthopaedic ceramic (Al2O3) and metal (CoCr alloy) particles

(2010) Aikaterini Tsaousi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Increased metal allergy in patients with failed metal-on-metal hip arthroplasty and peri-implant T-lymphocytic inflammation

(2009) P. Thomas et al.   ALLERGY

Periprosthetic tissue reactions observed at revision of total intervertebral disc arthroplasty

(2009) Ilona M. Punt et al.   BIOMATERIALS

Co–Cr–Mo alloy particles induce tumor necrosis factor alpha production in MLO-Y4 osteocytes: A role for osteocytes in particle-induced inflammation

(2009) Arihiko Kanaji et al.   BONE

Immunologic Adverse Reaction Associated with Low-carbide Metal-on-metal Bearings in Total Hip Arthroplasty

(2009) Panagiotis Aroukatos et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Retrieval Analysis of a ProDisc-L Total Disc Replacement

(2009) Theodore J. Choma et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: A novel mechanism for implant debris reactivity

(2008) Marco S. Caicedo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty

(2008) Nadim Hallab et al.   Journal of Orthopaedic Surgery and Research

Methotrexate Bearing Calcium Pectinate Microspheres: A Platform to Achieve Colon-Specific Drug Release

(2008) M. Chaurasia et al.   Current Drug Delivery

Titanium particles that have undergone phagocytosis by macrophages lose the ability to activate other macrophages

(2007) Zhiqing Xing et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS