Article
Biochemistry & Molecular Biology
Deepa Thomas, Neethu Mathew, Megha S. Nath
Summary: In this study, starch-modified alginate nanoparticles were developed for drug delivery application using a green facile technique. The nanoparticles demonstrated pH-dependent drug release characteristics and biocompatibility against L929 fibroblast cell lines. The preliminary investigation suggests the developed nanoparticles as a promising candidate for drug delivery application.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Agata Noelia Traverso, David Jose Fragale, Diego Luis Viale, Octavio Garate, Pablo Torres, Gaston Valverde, Alejandro Berra, Ana Vanesa Torbidoni, Juan Sebastian Yakisich, Mariano Grasselli, Martin Radrizzani
Summary: In this study, a two-step procedure for preparing biohybrid nanoparticles with a hydrophobic quantum dot core and a multilayer coating of human serum albumin is reported. These nanoparticles, decorated with proteins like human serum albumin or human transferrin, retained their fluorescent properties and showed no corona effect in the presence of serum. They were selectively taken up by lung cancer and neuroblastoma cells but not by non-cancerous cells or differentiated neurons. Moreover, digitoxin-loaded transferrin-decorated nanoparticles specifically reduced the number of lung cancer cells. Finally, the in vivo uptake of these biohybrid nanoparticles by retinal cells in mice demonstrated their excellent targeting and traceability.
Article
Chemistry, Multidisciplinary
Candace M. Day, Martin J. Sweetman, Yunmei Song, Sally E. Plush, Sanjay Garg
Summary: Functionalized nanoparticles have shown promising potential in targeted therapy through studies on loading capacity and release kinetics, contributing to the development of future stimuli-responsive nano-drug delivery systems.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Neera Raghav, Chanchal Vashisth, Nitika Mor, Priyanka Arya, Manishita R. Sharma, Ravinder Kaur, Surender P. Bhatti, John F. Kennedy
Summary: Polymers-based drug delivery systems are actively studied in the medicinal and pharmaceutical industries. Properties of polymers have been modified to enhance solubility, release kinetics, targeted action site, absorption, and therapeutic efficacy. Natural polymers are preferred due to their easy availability, accessibility, and non-toxicity. This review focuses on oral drug delivery systems using four natural polymers, cellulose, pectin, carrageenan, and alginate, and provides a concise and tabulated summary of relevant literature from the last five years.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Adelina-Gabriela Niculescu, Alexandru Mihai Grumezescu
Summary: Chitosan and alginate, two natural polymers, have attracted significant interest for their various applications in nano form. They have shown potential in biomedical, environmental protection, and food industry fields, serving as delivery vehicles, antimicrobial agents, and more. This paper discusses the latest applications of chitosan-alginate-based nanomaterials and serves as a starting point for further research.
Review
Polymer Science
Viktoria Hornok
Summary: This paper summarizes the research results on serum albumin-based nanoparticles for drug delivery purposes, focusing on their preparation techniques, synthesis parameters, and successful clinical applications. Despite promising possibilities, products made from different types of albumin nanoparticles, with the exception of a few, have not been invented yet. The paper also discusses promising applications of serum albumin nanoparticles for various biomedical purposes, such as carriers, delivery systems, and contrast agents.
Review
Chemistry, Multidisciplinary
Anna L. Neuer, Inge K. Herrmann, Alexander Gogos
Summary: The field of nanomedicine is rapidly advancing with a focus on inorganic and inorganic-organic composite nanomaterials. However, challenges remain in using these materials in clinical trials due to their complex chemistry and potential degradation. This review discusses recent advances in understanding the biochemical transformations of these materials, provides a refined terminology for primary reaction mechanisms, and highlights suitable analytical techniques. The review also highlights opportunities for diagnostic and therapeutic purposes, as well as current challenges and research priorities.
Review
Pharmacology & Pharmacy
Alaa Mansour, Maya Romani, Anirudh Balakrishna Acharya, Betul Rahman, Elise Verron, Zahi Badran
Summary: Modern drug discovery methods have led to the development of new drugs with significant potential, but properties like solubility and administration challenges may hinder their benefits. Biotechnology advances have also resulted in the development of molecules with short half-lives, requiring frequent administration. Controlled release systems are necessary to enhance treatment efficacy and improve patient compliance. This review provides an overview of different approaches used for drug delivery.
Review
Chemistry, Applied
Jaya R. Lakkakula, Pratik Gujarathi, Prachi Pansare, Swastika Tripathi
Summary: Combining alginate with other materials as a drug delivery system can effectively enhance the targeted therapeutic effects of doxorubicin on cancer, showing great potential for widespread applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Environmental
Han Luo, Jianyong Sheng, LinLin Shi, Xiaoyu Yang, Jitang Chen, Tianhao Peng, Qibing Zhou, Jiangling Wan, Xiangliang Yang
Summary: The one-step Fenton method offers a unique and green solution to produce protein NPs, which demonstrated promising antitumor efficacy, pharmacokinetic profiles, and safety. This approach is applicable not only to BSA NPs but also to other proteins, providing a novel strategy for effective drug delivery carrier production in biomedical applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Dinakar Swastha, Nambolan Varsha, Suresh Aravind, Kavassery Balasubramanian Samyuktha, Muruganandam Mohaneswari Yokesh, Akshad Balde, Bakthavatchalam Loganathan Ayilya, Soottawat Benjakul, Se -Kwon Kim, Rasool Abdul Nazeer
Summary: Inflammatory bowel disease (IBD) is a common inflammatory disorder affecting the gastrointestinal tract. Alginate (AG), as a marine-derived polysaccharide, has been extensively studied for its properties in drug delivery systems for IBD treatment. AG-based carrier systems, including nanotechnology-based systems and hydrogels, have shown potential in targeted drug delivery and tissue regeneration. This review focuses on the pathogenesis of IBD, currently studied medications, AG-based drug delivery systems, and their properties for alleviating IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Victoria Soares Soeiro, Ricardo Silva-Carvalho, Daniela Martins, Pier Parpot, Denise Grotto, Marco Vinicius Chaud, Francisco Miguel Portela da Gama, Angela F. Jozala
Summary: Nanocomplexes systems made up natural polymers have pharmacotechnical advantages by increasing water solubility and decreasing drug toxicity. By covering Amphotericin B with nanocrystals from bacterial cellulose, the nanocomplexes showed improved biocompatibility and reduced cytotoxicity, making them a potentially non-toxic alternative for drug delivery.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Huanhuan Guo, Zongguang Tai, Fang Liu, Jing Tian, Nan Ding, Zhongjian Chen, Shen Gao
Summary: Over the past decade, the dose of nanoparticles given to solid tumors has remained relatively consistent. The majority of nanoparticles are trapped in the mononuclear phagocyte system, with Kupffer cells representing 85% of this system. This study investigates the threshold doses of bovine serum albumin nanoparticles for uptake by Kupffer cells and demonstrates the improved antitumor effect and safety of albumin-bound paclitaxel when using the threshold doses of nanoparticles.
Article
Chemistry, Medicinal
Aruzhan Saparbayeva, Juho Lee, Shwe Phyu Hlaing, Jihyun Kim, Dongmin Kwak, Hyunwoo Kim, Eun Hee Lee, Seonghwan Hwang, Min-Soo Kim, Hyung Ryong Moon, Yunjin Jung, Jin-Wook Yoo
Summary: Colon-targeted oral drug delivery systems using nanoparticles and microparticles show promise in treating ulcerative colitis (UC) by reducing side effects and increasing local drug concentration.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Shuxia Cui, Hanzhe Liu, Guanglin Cui
Summary: Oral squamous cell carcinoma (OSCC) is a common malignancy worldwide. Current medical therapies for OSCC, such as chemotherapy, radiotherapy, and immunotherapy, are not ideal due to their low efficiency. To overcome this limitation, nanotechnology has been utilized to develop nanoparticles (NPs) as a more effective drug delivery system (DDS). NPs formulated with anticancer drugs have shown promising results in improving drug release and concentration at the tumor site, suggesting their potential as DDSs for the treatment of OSCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Carmen Guadalupe Rodriguez-Gonzalez, Ana Herranz-Alonso, Vicente Escudero-Vilaplana, Maria Aranzazu Ais-Larisgoitia, Irene Iglesias-Peinado, Maria Sanjurjo-Saez
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2019)
Article
Pharmacology & Pharmacy
Nuria Montero, Elena Perez, Marta Benito, Cesar Teijon, Jose Maria Teijon, Rosa Olmo, M. Dolores Blanco
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Health Care Sciences & Services
Maria Belen Marzal-Alfaro, Vicente Escudero-Vilaplana, Carmen Guadalupe Rodriguez-Gonzalez, Eva Gonzalez-Haba, Aitana Calvo, Santiago Osorio, Irene Iglesias-Peinado, Ana Herranz, Maria Sanfurjo
Summary: This study aimed to analyze the prevalence of errors and associated costs with the implementation of an image-based workflow management system during the antineoplastic compounding process. Results showed that Phocus Rx system effectively prevented errors reaching patients and was cost-effective from the hospital's perspective.
JOURNAL OF PATIENT SAFETY
(2021)
Article
Health Care Sciences & Services
Mbelen Marzal-Alfaro, Carmen Guadalupe Rodriguez-Gonzalez, Vicente Escudero-Vilaplana, Jose Luis Revuelta-Herrero, Eva Gonzalez-Haba, Sara Ibanez-Garcia, Irene Iglesias-Peinado, Ana Herranz-Alonso, Maria Sanjurjo Saez
HEALTH INFORMATICS JOURNAL
(2020)
Article
Pharmacology & Pharmacy
Roberto Collado-Borrell, Vicente Escudero-Vilaplana, Almudena Ribed, Rosa Romero Jimenez, Irene Iglesias Peinado, Ana Herranz-Alonso, Maria Sanjurjo-Saez
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2020)
Article
Pharmacology & Pharmacy
Estrella Diaz Gomez, David Suarez Del Olmo, Laura Corregidor Luna, Irene Iglesias-Peinado, Benito Garcia Diaz
Summary: This study evaluates the risk of bleeding in patients with renal insufficiency during treatment or prophylaxis with dalteparin and finds that patients with renal insufficiency are at a higher risk of bleeding than those with normal renal function.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2022)
Article
Health Care Sciences & Services
Roberto Collado-Borrell, Vicente Escudero-Vilaplana, Almudena Ribed, Cristina Gonzalez-Anleo, Maite Martin-Conde, Rosa Romero-Jimenez, Irene Iglesias-Peinado, Ana Herranz-Alonso, Maria Sanjurjo-Saez
JMIR MHEALTH AND UHEALTH
(2020)
Article
Pharmacology & Pharmacy
Lorena de Agustin Sierra, Jaime Rodriguez Salazar, Ana Belen Jimenez-Munoz, Maria Jesus Molina Hernandez, Paloma Bermejo Bescos, Irene Iglesias Peinado, Benito Garcia Diaz
Summary: Compared the prevalence of potentially inappropriate medication in the elderly using PRISCUS list, STOPP criteria, and Beers criteria. Found that explicit criteria are useful for identifying inappropriate medication use in elderly patients, with further research needed for adaptation and improvement of prescription practices.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Silvia Pena-Cabia, Ana Royuela Vicente, Ruth Ramos Diaz, Fernando Gutierrez Nicolas, Angela Penalver Vera, Isabel Siso Garcia, Ricardo Hitt Sabag, Concepcion Garcia Lacalle, Ana Pena-Cabia, Irene Iglesias-Peinado, Benito Garcia Diaz, Ana Lopez-Martin
Summary: Limited literature is available on the exposure-response relationship of bevacizumab, and no concentration threshold is associated with optimal disease control. This real-life observational study aimed to evaluate the relationship between bevacizumab concentrations at steady state and disease control in patients with metastatic colorectal cancer. While no positive association was found with clinical benefit, a higher median Ctrough, SS was associated with better overall survival. More controlled randomized studies are needed to confirm these findings.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Polymer Science
Ana Maria Martinez-Relimpio, Marta Benito, Elena Perez-Izquierdo, Cesar Teijon, Rosa Maria Olmo, Maria Dolores Blanco
Summary: Utilizing folate-targeted crosslinked nanoparticles based on BSA and alginate mixtures loaded with paclitaxel (PTX) has shown promising results in cancer treatment by enhancing the drug's antineoplastic activity against solid tumors. The sustained release of PTX from the nanoparticles led to a gradual decrease in cell viability, demonstrating the efficacy of the targeted nanocarriers in delivering the drug to cancer cells with overexpressed folate receptors.
Article
Immunology
Gonzalo Ruiz-Perez, Samuel Ruiz de Martin Esteban, Sharai Marques, Noelia Aparicio, M. Teresa Grande, Irene Benito-Cuesta, Ana M. Martinez-Relimpio, M. Andrea Arnanz, Rosa M. Tolon, Maria Posada-Ayala, Benjamin F. Cravatt, Jose A. Esteban, Julian Romero, Rocio Palenzuela
Summary: The study investigates the cellular and molecular mechanisms associated with improving neurodegeneration in 5xFAD mouse model by modulating the endocannabinoid system. The results demonstrate that increasing endocannabinoid tone rescues hippocampal synaptic plasticity and triggers augmented microglial activation and amyloid beta phagocytosis, leading to reversal of the neuronal phenotype associated with Alzheimer's disease.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Pharmacology & Pharmacy
Samuel Ruiz de Martin Esteban, Irene Benito-Cuesta, Itziar Terradillos, Ana M. Martinez-Relimpio, M. Andrea Arnanz, Gonzalo Ruiz-Perez, Claudia Korn, Catarina Raposo, Roman C. Sarott, Matthias V. Westphal, Izaskun Elezgarai, Erick M. Carreira, Cecilia J. Hillard, Uwe Grether, Pedro Grandes, M. Teresa Grande, Julian Romero
Summary: The cannabinoid CB2 receptors are found to be significantly elevated in chronic neuroinflammatory states associated with neurodegenerative diseases such as Alzheimer's disease, suggesting a potential therapeutic target in modulating amyloid metabolism through microglial CB2 receptors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Elsa Izquierdo-Garcia, Ismael Escobar-Rodriguez, Jose Manuel Moreno-Villares, Irene Iglesias-Peinado
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2020)
