期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 98A, 期 4, 页码 554-566出版社
WILEY
DOI: 10.1002/jbm.a.33148
关键词
bacterial cellulose; RGD; cellulose-binding module; blood compatibility; vascular grafts
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil)
- Programa Operacional Factores de Competitividade (COMPETE)
- Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) [PTDC/EDB/EBI/112170/2009]
- Fundação para a Ciência e a Tecnologia [PTDC/EBB-EBI/112170/2009] Funding Source: FCT
Among the strategies to improve a material's hemocompatibility, pre-coating with the tripeptide Arg-Gly-Asp (RGD) is used to favor endothelialization thus lowering thrombogenicity. The blood compatibility of native and RGD-modified bacterial cellulose (BC) was studied in this work for the first time. The plasma recalcification time and whole blood clotting results demonstrate the hemocompatibility of BC. A significant amount of plasma protein adsorb to BC fibres, however, according to analysis by intrinsic tryptophan fluorescence techniques when albumin, gamma-globulin, and fibrinogen from pure protein solutions adsorb to BC do not undergo detectable conformational modifications. Human microvascular endothelial cells cultured on RGD-modified BC readily form a confluent cell layer, inhibiting the adhesion of platelets. As a general conclusion, both native and RGD-modified BCs may be classified as hemocompatible materials. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 98A: 554-566, 2011.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据