期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 97A, 期 1, 页码 27-36出版社
WILEY
DOI: 10.1002/jbm.a.33013
关键词
implant; titanium alloy; cell adhesion; biocompatibility; cell differentiation
资金
- Council of Scientific and Industrial Research
- Department of Biotechnology, Government of India [GAP0220, GAP0311]
- ARC
- Indo-Australian Biotechnology Fund
The success of an implant used for bone regeneration and repair is determined by the events that take place at the cell-material interface. An understanding of these interactions in vitro gives insights into the formulation of ideal conditions for their effective functioning in vivo. Thus, it is not only important to understand the physico-chemical properties of the materials but, also necessary to assess the cellular responses to them to determine their long-term stability and efficacy as implants. In the present study, we have compared the physico-chemical and biological properties of titanium (Ti) and two Ti-based alloys, namely: Ti-Zirconium (TiZr) and Ti-Niobium (TiNb). The morphology, chemical analysis, surface roughness, and contact angle measurements of the alloys were assessed by scanning electron microscopy (SEMI, X-ray photoelectron spectroscopy (XPS), profilometer, and contact angle goniometer, respectively whereas the biological properties of the materials were evaluated by measuring the adhesion, proliferation, and differentiation of MC3T3-E1 osteoblast cells on the surfaces of these alloys. Our results indicate that the biological properties of osteoblasts were better on TiZr surface than on TiNb surface. Furthermore, the surface energy and substrate composition influenced the superior biological activity of the TiZr alloy. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 97A: 27-36, 2011.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据