期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 100A, 期 1, 页码 18-25出版社
WILEY
DOI: 10.1002/jbm.a.33219
关键词
block copolymers; atomic force microscopy; X-ray photoelectron spectroscopy; protein conformation
资金
- NSF-DMR [0114098]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0114098] Funding Source: National Science Foundation
Conformational changes of fibronectin (Fn) deposited on poly(methyl methacrylate) and poly(acrylic acid) block copolymers with identical chemical compositions were detected using an antibody-functionalized atomic force microscope (AFM) tip. Based on the antibody-protein adhesive force maps and phase imaging, it was found that the nanomorphology of the triblock copolymer is conducive to the exposure of the arginine-glycine-aspartic acid (RGD) groups in Fn. For the first time, X-ray photoelectron spectroscopy was used to elucidate surface chemical composition and confirm AFM results. The findings demonstrate that block copolymer nanomorphology can be used to regulate protein conformation and potentially cellular response. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A: 18-25, 2012.
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