期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 92A, 期 1, 页码 311-321出版社
WILEY
DOI: 10.1002/jbm.a.32366
关键词
polycaprolactone; scaffold; sodium hydroxide; surface roughness; calvaria
资金
- National Dental Centre, Sing-Health, Singapore [022/07-25380020]
- ExxonMobil-NUS Research Fellowship Award
Pretreatment of polycaprolactone-20% tricalcium phosphate (PCL-TCP) scaffolds under alkaline conditions can be utilized to alter surface characteristics for enhanced early bone formation. PCL-TCP scaffolds were treated with sodium hydroxide (NaOH) at various time intervals (group A: untreated, group B: 3M NaOH for 48 h, and group C: 3M NaOH for 96 h). In vitro results showed a greater degree of physical changes in the NaOH-treated scaffolds (B and Q than the untreated group (A). Clearly, the NaOH-treated scaffolds showed an increased surface roughness than the untreated ones. A significantly large number of channel-like pits and greater average pit sizes were detected in groups B (14.51 +/- 10.9 mu m) and C (20.27 +/- 14.3 mu m); and absent in group A. In addition, treated scaffolds had a significant reduction of the water contact angle (40.9-58.2%,). Favorably, the pore dimensions and scaffold rod thickness remained unchanged throughout the experiment. When implanted in the calvaria of rabbits, NaOH-treated scaffolds reported greater early matrix deposition and bone formation from scanning electron images and Micro-computed tomography analyses. In conclusion, pretreatment of PCL-TCP scaffolds with NaOH increases the wettability and surface area for initial matrix deposition and early bone ingrowth. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 92A: 311-321, 2010
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