期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 96A, 期 1, 页码 75-82出版社
WILEY-BLACKWELL
DOI: 10.1002/jbm.a.32958
关键词
carbon nanotube; osteoblast; titanium; critical sized defect; mineralization
资金
- University of Minnesota
- NSF
The effects of a layer-by-layer assembled carbon nanotube composite (CNT-comp) on osteoblasts in vitro and bone tissue in vivo in rats were studied. The effects of CNT-comp on osteoblasts were compared against the effects by commercially pure titanium (cpTi) and tissue culture dishes. Cell proliferation on the CNT-comp and cpTi were similar. However, cell differentiation, measured by alkaline phosphatase activity and matrix mineralization, was better on the CNT-comp. When implanted in critical-sized rat calvarial defect, the CNT-comp permitted bone formation and bone repair without signs of rejection or inflammation. These data indicate that CNT-comp may be a promising substrate for use as a bone implant or as a scaffold for tissue engineering. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 96A: 75-82, 2011.
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