Article
Materials Science, Characterization & Testing
Lidong Feng, Sheng Xiang, Yanlong Liu, Xinchao Bian, Gao Li, Xuesi Chen
Summary: An analytical method using gas chromatography with an internal standard was developed to quantitatively determine residual monomers in PLCL, which showed high precision with RSD less than 5.6% and 4.3% for LA and CL measurements, respectively. The recovery rate of standard addition for LA and CL in PLCL was between 96.5%-101.5% and 98.4%-104.2%, with RSD not exceeding 2.0%, indicating the method was sufficiently accurate.
Article
Chemistry, Multidisciplinary
Begum Canan Yildiz, Asgar Kayan
Summary: Titanium (IV) silyliminophenolate complexes were synthesized and shown to be active catalysts for the ring-opening polymerization of epsilon-caprolactone and L-lactide. The structures of compounds were elucidated using spectroscopic and thermal analysis methods, and resulting polymers were characterized using gel permeation chromatography.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Polymer Science
Martin Castillo-Santillan, Jose Roman Torres-Lubian, Antonio Martinez-Richa, Silvia T. Huerta-Marcial, Maria C. Gutierrez, Katja Loos, Maria Guadalupe Perez-Garcia, Josue D. Mota-Morales
Summary: This work provides new insights into the ring-opening polymerization of L-lactide and e-caprolactone, leading to the synthesis of polymer blends and a block copolymer. The selection of parameters and catalysts allows for the production of polyesters with tunable properties and controlled degradation profiles.
Article
Immunology
Yingjie Wang, Shanqiu Jian, Wen Li, Ling Zhao, Gang Ye, Fei Shi, Lixia Li, Yuanfeng Zou, Xu Song, Xinghong Zhao, Zhongqiong Yin, Yinglun Li, Huaqiao Tang
Summary: This study evaluated the protective effect of epigallocatechin gallate (EGCG) on liver damage secondary to P. aeruginosa infection. The results showed that EGCG reduced liver function markers, improved histopathological changes, reduced oxidative stress and inhibited inflammation response. EGCG exerted its liver protective effect through regulation of multiple signaling pathways, providing a new therapeutic strategy for P. aeruginosa infection-related liver damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Chemistry, Applied
Takashi Tanaka, Miho Yasumatsu, Mayu Hirotani, Yosuke Matsuo, Na Li, Hong-Tao Zhu, Yoshinori Saito, Kanji Ishimaru, Ying-Jun Zhang
Summary: This study investigated the reaction of Theanaphthoquinone (TNQ) with epigallocatechin-3-O-gallate (EGCg) in black tea leaves, revealing the formation of novel reaction products and providing new insights into the formation of black tea pigment thearubigins.
Article
Materials Science, Multidisciplinary
Thannaphat Jenvoraphot, Boontharika Thapsukhon, Donraporn Daranarong, Robert Molloy, Chayarop Supanchart, Suttichai Krisanaprakornkit, Paul D. Topham, Brian Tighe, Anisa Mahomed, Winita Punyodom
Summary: In this research, a periodontal membrane with nanoporous structure and tetracycline drug loading was designed and fabricated to improve periodontal regeneration and anti-inflammatory effect.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Wei Xu, Xianying Song, Qingyun Qu, Zhihua Gong, Wenjun Xiao
Summary: This study found that an intervention using l-theanine (LTA) and epigallocatechin gallate (EGCG) can alleviate ovalbumin allergy (OVA-A) by modulating intestinal-specific immunity. The combination of LTA and EGCG has a better effect than using them separately. Moreover, LTA and EGCG also improve OVA-A by reducing the number of dendritic cells, inhibiting the Th2 immune response, and inhibiting mast cell degranulation.
Article
Reproductive Biology
Ricassio S. Barberino, Thae Lanne B. G. Lins, Alane P. O. Monte, Regina Lucia S. Silva, Kscyla O. Andrade, Daniela S. P. Campinho, Raimundo C. Palheta Junior, Johan E. J. Smitz, Maria Helena T. Matos
Summary: This study evaluated the protective effects of EGCG against ovarian toxicity in cyclophosphamide-treated mice and identified potential mechanisms involving phosphorylated Akt, FOXO3a, and rpS6. The results showed that pretreatment with EGCG preserved normal follicular morphology, prevented follicle loss, reduced atresia, inflammation, and mitochondrial damage, and increased GSH concentrations. EGCG also regulated phosphorylated Akt, FOXO3a, and rpS6 levels. These findings suggest that short-term pretreatment with EGCG can protect against ovarian damage induced by cyclophosphamide.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Immunology
Huanhuan Xu, Titi Liu, Yuankan Jia, Jin Li, Li Jiang, Caijiang Hu, Xuanjun Wang, Jun Sheng
Summary: EGCG in green tea can inhibit osteoclastogenesis by interfering with the interaction between RANK and RANKL, suppressing the phosphorylation of key regulatory factors, and negatively regulating NF-kappa B and MAPK signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
So-Ra Kim, Kyung-Joo Seong, Won-Jae Kim, Ji-Yeon Jung
Summary: EGCG protects microglia from hypoxia-induced inflammation and oxidative stress through inhibition of the NF-κB pathway and activation of the Nrf-2/HO-1 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chengyu Jiang, Li Wang, Xin Huang, Song Zhu, Chaoyang Ma, Hongxin Wang
Summary: Vinyl stearate was used in the enzymatic transesterification of EGCG to enhance its lipophilicity and antioxidant abilities, achieving a stearyl derivative with significantly improved lipid oxidation and potential applications in high-fat foods.
Review
Biochemistry & Molecular Biology
Ryuuta Fukutomi, Tomokazu Ohishi, Yu Koyama, Monira Pervin, Yoriyuki Nakamura, Mamoru Isemura
Summary: Various studies suggest that plant polyphenols in diets have beneficial effects on diseases like cancer, obesity, diabetes, cardiovascular diseases, and NDDs. Representative polyphenols include epigallocatechin-3-O-gallate, chlorogenic acids, resveratrol, and curcumin. Human studies show the benefits of these foods on NDDs, while cellular animal experiments provide molecular basis for their effects.
Article
Materials Science, Multidisciplinary
Fanny Bonnet, Bernard Miranda Campos, Gaelle Fontaine, Serge Bourbigot, Gregory Stoclet
Summary: In this study, PLLA-based/glass fabric composites with poly(L-lactide-co-e-caprolactone) as the matrix were reported, displaying high wettability and toughness.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Shweta Sagar, Kulsum Bano, Alok Sarkar, Kuntal Pal, Tarun K. Panda
Summary: A novel sulfur-supported magnesium complex was developed as a catalyst for ring-opening polymerization of rac-lactide and epsilon-caprolactone. This catalyst showed high selectivity for rac-lactide polymerization, resulting in isoselective PLA with a P-i value of 0.77. The polymerization proceeded under mild reaction conditions without the need for an external initiator, and the resulting polyesters exhibited good control over the molecular weight.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Engineering, Biomedical
Ganchimeg Davaa, Jin Young Hong, Jung-Hwan Lee, Min Soo Kim, Jennifer O. Buitrago, Yu-Meng Li, Hae-Hyoung Lee, Dong Wook Han, Kam W. Leong, Jung Keun Hyun, Hae-Won Kim
Summary: Neural stem cells (NSC) have the potential to regenerate injured neural tissues, but suffer from low survival and uncontrolled differentiation. This study demonstrates that mechanically-tuned protein hydrogels can protect and enhance the long-term survival of reprogrammed NSC, alleviate neural inflammation, promote differentiation, and improve locomotor functions in treating injured spinal cord.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Seon Yeong Chae, Sangheon Jeon, Dong-Wook Han, Suck Won Hong
Summary: Researchers have investigated the excellent antibacterial activity of graphene-based materials, which utilize the unique mechanical, electrical, and surface properties of graphene, to address the challenges of bacterial drug resistance and emerging infectious diseases. The antibacterial mechanism involves physical damage and chemical interactions between graphene and bacterial membranes. A simple manufacturing process was also developed to create three-dimensionally arranged graphene oxide films, which exhibited antibacterial activity.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Review
Biochemistry & Molecular Biology
Moon Sung Kang, Jinju Jang, Hyo Jung Jo, Won-Hyeon Kim, Bongju Kim, Heoung-Jae Chun, Dohyung Lim, Dong-Wook Han
Summary: This review focuses on the advances and innovations of 3D bioprinted skin for skin regeneration. By improving materials, structures, and functions, the clinical potential of 3D bioprinted skin has been enhanced. With state-of-the-art printing technology and novel biomaterials, highly developed skin comprising stratified epidermis, dermis, and hypodermis with blood vessels, nerves, muscles, and skin appendages can be fabricated. We hope that this review will guide future research and clinical applications.
Article
Nanoscience & Nanotechnology
Sangmun Choi, Iruthayapandi Selestin Raja, Aravindha Raja Selvaraj, Moon Sung Kang, Tae-Eon Park, Ki Su Kim, Suong-Hyu Hyon, Dong-Wook Han, Jong-Chul Park
Summary: Carbon nanotubes are commonly used one-dimensional carbonaceous nanomaterials in tissue engineering, while other forms of one-dimensional nanomaterials, such as carbon nanowires and carbon nanofibers, have not been extensively explored for biomedical applications. In this study, activated carbon nanofiber nanoparticles (ACNF NPs) were synthesized from polyacrylonitrile electrospun nanofibers. Two different types of ACNF NPs-containing electrospun polycaprolactone (PCL) nanofiber mats were prepared and evaluated for their potential as skin tissue engineering scaffolds. The results showed that ACNF NPs exhibited a graphitization degree with an I-D/I-G ratio of 1.05, and had a diameter of 280 +/- 100 nm and a length of 565-3322 nm. NPs with a concentration above 30 μg/mL exhibited toxicity to NIH3T3 fibroblasts. The ACNF-PCL nanofiber mats demonstrated better cell proliferation compared to PCL and ACNF@PCL mats. Therefore, it can be concluded that ACNF-PCL mats with a lower concentration of ACNF NPs have greater potential to support cellular growth and impact skin tissue regeneration.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2023)
Review
Engineering, Biomedical
Iruthayapandi Selestin Raja, Moon Sung Kang, Suck Won Hong, Hojae Bae, Bongju Kim, Yu-Shik Hwang, Jae Min Cha, Dong-Wook Han
Summary: Biofabrication approaches, such as 3D bioprinting of hydrogels, have gained increasing attention for their ability to construct complex 3D tissue and organ structures. However, the stability and shape fidelity of printed gels can be affected by various factors. To address this, researchers have incorporated different nanomaterials into polymeric hydrogels. This review discusses CFNs-containing printable gels in various biomedical applications, including the types of bioprinters, prerequisites of bioink and biomaterial ink, and the progress and challenges in this field.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Biochemistry & Molecular Biology
Gyeonghyeon Kim, Dong-Wook Han, Jong Hun Lee
Summary: In this study, baicalein was found to have antioxidant effects and could protect HaCaT keratinocytes from H2O2-induced oxidative stress by maintaining mitochondrial homeostasis and cellular tight junctions.
Article
Multidisciplinary Sciences
Seok Hyun Lee, Moon Sung Kang, Sangheon Jeon, Hyo Jung Jo, Suck Won Hong, Bongju Kim, Dong-Wook Han
Summary: Contemporary advances in 3D bioprinting have allowed for the creation of personalized live 3D tissue mimetics. The development of bioink materials that accurately replicate the composition of native extracellular matrix and mimic cell properties has been emphasized. In this study, MXene-incorporated GelMA/HAMA bioinks were prepared to investigate their potential for spontaneous osteodifferentiation of human mesenchymal stem cells (hMSCs) when used for 3D printing. The GelMA/HAMA-MXene hydrogels were found to provide favorable matrices for hMSCs growth and survival, and hMSCs were shown to differentiate into osteoblasts in the GelMA-HAMA/MXene composites, creating a favorable microenvironment for bone regeneration. These findings suggest that MXene-incorporated GelMA/HAMA bioink has significant biofunctional advantages for the development of effective scaffolds in bone tissue regeneration.
Article
Biotechnology & Applied Microbiology
Yeokyung Kang, Jungsung Kim, Jae Ang Sim, Myeong Moon, Jong-Chul Park, Sung Ha Cho, Byung Hoon Lee
Summary: Proximal fibular osteotomy effectively relieves stress and redistributes the load in patients with medial compartment knee osteoarthritis. The study used finite element method to evaluate the clinical effect of fibular osteotomy and found a significant reduction in stress in the medial direction of meniscus and cartilage.
BIOENGINEERING-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Xiaoting Ma, Won-Hyeon Kim, Jong-Ho Lee, Dong-Wook Han, Sung-Ho Lee, Jisung Kim, Dajung Lee, Bongju Kim, Dong-Myeong Shin
Summary: The study developed an air-barrier device to reduce bioaerosol contamination in dental environments. Through simulation and experiments, it was demonstrated that the air-barrier device effectively reduces the generation of bioaerosols in dental environments. This study shows that air-barrier devices play an effective role in reducing contaminating particles in dental environments.
BIOENGINEERING-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Hee Jeong Jang, Moon Sung Kang, Won-Hyeon Kim, Hyo Jung Jo, Sung-Ho Lee, Eun Jeong Hahm, Jung Hyun Oh, Suck Won Hong, Bongju Kim, Dong-Wook Han
Summary: We used 3D printing to fabricate graphene oxide (GO)-incorporated polylactic acid (PLA) films and explored their benefits as barrier membranes in guided bone regeneration (GBR). Our results showed that the 3D printed GO-PLA films provided a favorable environment for preosteoblasts and promoted new bone formation in rat calvarial bone defect models.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Anara Molkenova, Lazzat Serik, Alina Ramazanova, Kamila Zhumanova, Bakyt Duisenbayeva, Ainur Zhussupbekova, Kuanysh Zhussupbekov, Igor V. Shvets, Ki Su Kim, Dong-Wook Han, Timur Sh. Atabaev
Summary: Metal-doped carbon dots, specifically terbium-doped CDs, have been studied as a potential contrast agent for computed tomography. Physicochemical analysis showed that the prepared Tb-CDs have small sizes, high terbium concentration, and good colloidal stability. Preliminary tests also indicated that Tb-CDs have negligible cytotoxicity and demonstrate high X-ray absorption performance.
Article
Energy & Fuels
Dongkyu Choi, Hyuksang Kwon, Seonguk Lim, Taekyun Jeong, Heechul Jung, Yong-Il Kim, Dongwook Han
Summary: Ti-doped orthorhombic LiMn1-xTixO2 serves as a Co-and Ni-free cathode material for Li-ion rechargeable batteries with stable oxygen/cation site occupancy and cycling-dependent phase transition. The Ti doping improves the structural stability and reduces imperfections of the oxygen/cation lattices in LiMnO2. The electrochemically inactive cLiTiO2 phase suppresses the structural collapse of Ti-doped LiMnO2, resulting in higher discharge capacity and superior cycling performance compared to pristine LiMnO2.
Review
Chemistry, Physical
Moon Sung Kang, Hee Jeong Jang, Hyo Jung Jo, Iruthayapandi Selestin Raja, Dong-Wook Han
Summary: The emergence of 2D nanomaterials, especially graphene and Xene materials, has revolutionized biomedical applications such as bioimaging, drug delivery, and tissue engineering. This review focuses on comparing the use of graphene and Xene materials for fabricating tissue engineering scaffolds, and discusses methods to improve their clinical potential.
NANOSCALE HORIZONS
(2023)
Article
Engineering, Biomedical
Yeokyung Kang, Dasol Lim, Doo-Hoon Sun, Jong-Chul Park, Jungsung Kim
Summary: This study proposes three-dimensional printable bone augments as an alternative to surgeries for patients with severe bone defects in total hip arthroplasty. The bone augments are designed to bond from various angles and have good structural safety. Further research is needed to study the clinical applications of these bone augments.
BIO-DESIGN AND MANUFACTURING
(2023)