Article
Biochemistry & Molecular Biology
Anna Carla Culla, Corina Vater, Xinggui Tian, Julia Bolte, Tilman Ahlfeld, Henriette Bretschneider, Alexander Pape, Stuart B. Goodman, Michael Gelinsky, Stefan Zwingenberger
Summary: Composite materials and tissue-engineered bone grafts are important in bone repair. This study investigated the bone regenerative potential of hybrid scaffolds made of macroporous calcium phosphate cement (CPC) and microporous mineralized collagen matrix (MCM). The hybrid scaffolds showed more newly formed bone and enhanced biomechanical strength compared to other groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
M. Ethan Brown, Jennifer L. L. Puetzer
Summary: This study investigates the effect of compressive mechanical boundary conditions and the addition of beta-tricalcium phosphate (beta TCP) on the development of zonal ligament-to-bone entheses. The results show that compressive boundary clamps and beta TCP can guide ligament fibroblasts to produce zonal gradients in collagen organization, mineralization, and matrix composition, closely resembling immature ligament-to-bone attachments. This culture system provides a promising platform for understanding and promoting enthesis regeneration in graft repair and engineered replacements.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Ceramics
Manqi Yan, Yanan Zhao, Yue Dai, Xiaokang Yao, Honglian Dai
Summary: In this study, modified calcium magnesium phosphate bone cement (MCPC) composites were constructed by introducing gelatin solutions. The modified MCPC composites exhibited improved microenvironment, enhanced osteogenic differentiation and biomineralization. When incorporated with 1% and 5% of gelatin, the MCPC composites showed higher mechanical properties and osteogenic ability of BMSCs.
CERAMICS INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Yafei Yuan, Lipei Shen, Tiankun Liu, Lin He, Dan Meng, Qingsong Jiang
Summary: In this study, researchers developed a novel scaffold material for bone tissue engineering by encapsulating bone marrow mesenchymal stem cells (BMSCs) in alginate chitosan alginate (ACA) microcapsules and compounding them with calcium phosphate bone cement (CPC). The results showed that cells protected by microcapsules had better viability, proliferation, and adhesion compared to cells directly combined with CPC. The composite scaffold also exhibited better new bone formation function and degradability. These findings suggest that BMSCs encapsulated in ACA microcapsules combined with CPC composite scaffolds have promising applications in bone tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Lisha Meng, Yajin Li, Yu Wang, Jingshu Zhang, Yubiao Zhang, Yadong Chen, Tianxing Gong
Summary: This study developed a novel injectable bone cement for repairing bone fractures under osteoporotic conditions. LA-CPSC bone cement was found to enhance bone regeneration and reduce osteoclast activities, showing potential as a viable solution for bone fracture repair in osteoporotic patients.
BIOMEDICAL MATERIALS
(2021)
Review
Engineering, Multidisciplinary
Muhammad Aqib, Aneela Anwar, Humayun Ajaz, Samina Akbar, Ahsan Manzoor, Maham Abid, Zohaib Waheed, Qudsia Kanwal
Summary: In recent years, calcium phosphate cement has been widely used in biomedical applications due to its excellent biocompatibility, bioactivity, self-setting qualities, minimal setting degree, suitable toughness, and versatility in shape. Brushite, a type of calcium phosphate, is particularly attractive for bone repair and can also potentially serve as a drug delivery device. The addition of metal ions, such as magnesium, zinc, and strontium, into the calcium phosphate structure has become a major research focus. This paper provides a comprehensive analysis of the advancements and prospects of metal-doped brushite cement, including its impact on physical and chemical properties, as well as its potential applications in regenerative medicine.
JOURNAL OF BIONIC ENGINEERING
(2023)
Article
Materials Science, Ceramics
Zepeng Cai, Zhiwen Wu, Yi Wan, Tao Yu, Changren Zhou
Summary: The study prepared micronano calcium phosphate (MNC) with different Ca/P ratio and added it to CPC and CSC, showing significant improvements in mechanical properties and setting time of the cement. MNC promoted hydration reaction, affected crystal growth, and reduced porosity in the cement, delaying degradation.
CERAMICS INTERNATIONAL
(2021)
Article
Materials Science, Multidisciplinary
Jiawei Liu, Honglei Kang, Wenying Wei, Rong Tu, Takashi Goto, Feng Li, Honglian Dai
Summary: Bioactive calcium and magnesium phosphate bone adhesive (MPBA) is a promising material for the treatment of bone fractures and implant fixation. It has the advantages of easy preparation, strong adhesion, and biological activity, and can effectively restore bone strength and promote bone regeneration.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Polymer Science
Ioana Lacan, Marioara Moldovan, Codruta Sarosi, Ioan Ardelean
Summary: Calcium phosphate cements can be improved by adding additives such as chitosan. This study used nuclear magnetic resonance (NMR) to investigate the effect of chitosan on the hardening process of the cement and found that chitosan accelerates the hardening dynamics and reduces the amount of unreacted monomers.
Article
Biochemistry & Molecular Biology
Jennifer Blankenburg, Johannes Vinke, Bianca Riedel, Sergej Zankovic, Hagen Schmal, Michael Seidenstuecker
Summary: In this study, the adaptation of biological shapes in 3D printing of ceramic-based scaffolds was investigated. By adjusting the layer rotation angle, sample shapes with a rotation angle of only 1 degree were successfully printed. The maximum failure load of the samples was increased by changing the strand diameter and arrangement.
Article
Materials Science, Ceramics
Min Wei, Yufei Tang, Lei Chen, Bo Zhang, Shitong Zhang, Kang Zhao, Zixiang Wu
Summary: This study successfully introduced montmorillonite (MMT) into calcium phosphate cement (CPC) to prepare CPC/MMT composite bone cement. The compressive strength of the composite cement was significantly enhanced, and the anti-washout ability was improved as well. The composite bone cement also exhibited outstanding cell adhesion and proliferation abilities.
CERAMICS INTERNATIONAL
(2022)
Article
Engineering, Multidisciplinary
Wenjuan Liu, Zhiguang Huan, Chengtie Wu, Zhihua Zhou, Jiang Chang
Summary: This study developed a composite bone cement with high compressive strength and desirable bioactivity by incorporating calcium silicate bioceramic into magnesium phosphate bone cement. The composite bone cement showed significantly higher compressive strength compared to traditional bone cements and demonstrated apatite mineralization ability and moderate degradation behavior.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Polymer Science
Kai-Chi Chang, Jian-Chih Chen, I-Tse Cheng, Ssu-Meng Haung, Shih-Ming Liu, Chia-Ling Ko, Ying-Sui Sun, Chi-Jen Shih, Wen-Cheng Chen
Summary: Biomolecule-based templates for carbonated apatite synthesis show promise in bone tissue regeneration applications. Heparin and ferulic acid templates were used to enhance bone mineralization in this study. The newly developed biocompatible CPC + F-CHA composites have great potential as osteoconductive bone fillers for bone tissue engineering, although caution is advised when using over 10% F-CHA in load-bearing areas.
Review
Biotechnology & Applied Microbiology
Abhishek Indurkar, Rajan Choudhary, Kristaps Rubenis, Janis Locs
Summary: Bone is a composite material consisting of inorganic calcium phosphate and organic collagen. The mineralization of collagen plays a crucial role in the formation of bone and tooth. It has been found that synthetic calcium phosphate undergoes a transformation to apatite nanocrystals before entering the collagen gap zone. However, this transformation is hindered by a nucleation catalyst. Organic macromolecules and low-molecular-weight carboxylic compounds present in bone and tooth can interact with both apatite and collagen, controlling nucleation, crystal growth, and particle size. These compounds also prevent the transformation of calcium phosphate into apatite before entering the collagen gap zone. Therefore, understanding the role of these organic compounds is important in regulating collagen mineralization.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Zilgma Irbe, Dagnija Loca
Summary: Premixed calcium phosphate cement pastes have been proposed as biomaterials for bone tissue repair and regeneration, with alpha-Tricalcium phosphate (alpha-TCP) based cements setting to form calcium deficient hydroxyapatite. The use of mixture of basic and acidic potassium phosphate salts showed the best overall results in terms of cohesion, pH value, hydrolysis, and compressive strength of the cement.
CERAMICS INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Fang Li, Michael D. Weir, Jihua Chen, Hockin H. K. Xu
Article
Dentistry, Oral Surgery & Medicine
Fang Li, Michael D. Weir, Ashraf F. Fouad, Hockin H. K. Xu
Article
Engineering, Biomedical
Mary Anne S. Melo, Lei Cheng, Michael D. Weir, Ru-Ching Hsia, Lidiany K. A. Rodrigues, Hockin H. K. Xu
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2013)
Article
Dentistry, Oral Surgery & Medicine
Bashayer H. Baras, Jirun Sun, Mary Anne S. Melo, Franklin R. Tay, Thomas W. Oates, Ke Zhang, Michael D. Weir, Hockin H. K. Xu
Article
Dentistry, Oral Surgery & Medicine
Hong Chen, Yunhao Tang, Michael D. Weir, Jianghong Gao, Satoshi Imazato, Thomas W. Oates, Lei Lei, Suping Wang, Tao Hu, Hockin H. K. Xu
Article
Dentistry, Oral Surgery & Medicine
Wen Zhou, Xian Peng, Xuedong Zhou, Michael D. Weir, Mary Anne S. Melo, Franklin R. Tay, Satoshi Imazato, Thomas W. Oates, Lei Cheng, Hockin H. K. Xu
Article
Dentistry, Oral Surgery & Medicine
Xiuzhi Fei, Yuncong Li, Michael D. Weir, Bashayer H. Baras, Haohao Wang, Suping Wang, Jirun Sun, Mary A. S. Melo, Jianping Ruan, Hockin H. K. Xu
Article
Cell & Tissue Engineering
Gengtao Qiu, Mingguang Huang, Jin Liu, Ping Wang, Abraham Schneider, Ke Ren, Thomas W. Oates, Michael D. Weir, Hockin H. K. Xu, Liang Zhao
Summary: The novel CPCC + DOX scaffold demonstrated excellent mechanical properties and strong antibacterial activity, while also supporting proliferation and osteogenic differentiation of hPDLSCs. This scaffold has the potential to enhance bone regeneration and combat bone infections in dental, craniofacial, and orthopedic applications.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Heba Mitwalli, Rashed AlSahafi, Ebtehal G. Albeshir, Quan Dai, Jirun Sun, Thomas W. Oates, Mary Anne S. Melo, Hockin H. K. Xu, Michael D. Weir
Summary: The study developed a new bioactive nanocomposite with antibacterial and remineralizing properties by incorporating DMAHDM and nCaF2. The composites demonstrated good mechanical properties, potent antibacterial activity against biofilms, and high F and Ca ion releases, showing potential for preventing caries.
JOURNAL OF DENTISTRY
(2021)
Article
Engineering, Biomedical
Christopher J. Panebianco, Sanjna Rao, Warren W. Hom, James H. Meyers, Tiffany Y. Lim, Damien M. Laudier, Andrew C. Hecht, Michael D. Weir, Jennifer R. Weiser, James C. Iatridis
Summary: This study developed an injectable composite biomaterial using degradable oxidized alginate microbeads for delivering annulus fibrosus cells to injured intervertebral discs. The composite material achieved a balance between biomechanical and biological demands, providing promising results for cell delivery and repair.
Article
Dentistry, Oral Surgery & Medicine
Rashed AlSahafi, Heba Mitwalli, Abdullah Alhussein, Mary Anne S. Melo, Frederico Martinho, Christopher D. Lynch, Thomas W. Oates, Hockin H. K. Xu, Michael D. Weir
Summary: This study investigated the efficacy of a novel resin cement containing DMAHDM and NACP in inhibiting saliva microcosm biofilm. The results showed that the cement exhibited strong antibacterial action and continuous ion release, indicating its potential for remineralization.
JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hanan Filemban, Ghalia Bhadila, Xiaohong Wang, Mary Ann S. Melo, Thomas W. Oates, Gary D. Hack, Christopher D. Lynch, Michael D. Weir, Jirun Sun, Hockin H. K. Xu
Summary: This study developed a bioactive low-shrinkage-stress composite with antibacterial and remineralizing properties. After thermal cycling, the composite demonstrated good mechanical properties and maintained its strong antibacterial activity. This material shows great potential in inhibiting recurrent caries and increasing restoration longevity.
JOURNAL OF DENTISTRY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Wen Zhou, Hong Chen, Michael D. Weir, Thomas W. Oates, Xuedong Zhou, Suping Wang, Lei Cheng, Hockin H. K. Xu
Summary: This review provides an overview of cutting-edge research on the development of new bioactive restorations to inhibit secondary caries in enamel and dentin under biofilms. Novel bioactive materials are categorized based on their remineralization and antibacterial biofunctions. However, there is still a need for new intelligent and pH-responsive materials, and the evaluation should be performed using more clinically relevant biofilm-based secondary caries models.
JOURNAL OF DENTISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Ghalia Y. Bhadila, Bashayer H. Baras, Abdulrahman A. Balhaddad, Mary Ann Williams, Thomas W. Oates, Michael D. Weir, Hockin H. K. Xu
Summary: This study reviewed different recurrent caries models used to evaluate restorative materials and compared their methodology and parameters. Specific recommendations for future investigations were also provided.
JOURNAL OF DENTISTRY
(2023)
Article
Engineering, Biomedical
Michael D. Weir, Papatya Kaner, Alexander Marin, Alexander K. Andrianov
Summary: The study used novel polyphosphazenes to modify tooth surfaces, improving the stability of the bonded interface between composite restorations and teeth. Results showed significant and stable adsorption of polyphosphazenes onto teeth, potentially leading to a more stable bonded interface.
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2021)