期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 89A, 期 1, 页码 248-254出版社
WILEY-LISS
DOI: 10.1002/jbm.a.32025
关键词
thermoreversible gels; drug delivery; polymers; tissue engineering
Graft copolymers consisting of a poly(D,L-lactic acid-co-glycolic acid) backbone grafted with polyethylene glycol side chains were synthesized and formed thermoreversible gels in aqueous solutions that exhibited solution behavior at low temperature and sol-to-gel transitions at higher temperature. The composition of the polymer and relative amounts of polylactic acid, glycolic acid, and ethylene glycol were varied by controlling the precursor concentrations and reaction temperature. The gelation temperature could be systematically tailored from 1.5 to 34 degrees C by increasing the concentration of polyethylene glycol in the graft copolymer. The gelation temperature also depended on the polymer molecular weight and concentration. This work has importance for the development of water soluble gels with tailored compositions and gelation temperatures for use in tissue engineering and as injectable depots for drug delivery. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 89A: 248-254, 2009
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