期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 92A, 期 4, 页码 1476-1486出版社
WILEY-LISS
DOI: 10.1002/jbm.a.32439
关键词
titanium alloy; laser; biomechanics; focused ion beam; TEM (transmission electron microscopy); interface
资金
- Swedish Research Council [K2006-73X-09495-16-3]
- LUA project [ALFGBG-11128]
- VINNOVA ForskaVax [200602247]
- VINNOVA VinnVaxt Program Biomedical Development in Western Sweden
- BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Integrum AB
The aim of this study was to evaluate the biomechanical properties and ultrastructure of the bone response of partly laser-modified Ti6Al4V implants compared with turned, machined implants after 8 weeks in rabbit. The surface analyses performed with interference microscopy and electron microscopy showed increased surface topography with micro- and nano-sized surface features as well as increased oxide thickness of the modified surface. The biomechanical testing demonstrated a 270% increase in torque value for the Surface modified implants compared with the control implants. Histological evaluation of ground sections of specimens subjected to biomechanical testing revealed ongoing bone formation and remodeling. A histological feature exclusively observed at the laser-modified surface was the presence of fracture in the mineralized bone rather than at the interface between the bone and implant. Transmission electron microscopy (TEM) was performed on Focused Ion Beam (FIB) prepared samples of the intact bone-implant interface, demonstrating a direct contact between nanocrystalline hydroxyapatite and the oxide of the laser-modified implant surface. In conclusion, laser-modified titanium alloy implants have significantly stronger bone anchorage compared with machined implants and show no adverse tissue reactions. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 92A: 1476-1486, 2010
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