Article
Physiology
Ramon Paniagua, Elvia Garcia-Lopez, Marcela Avila-Diaz, Maria-de-Jesus Ventura, Oscar Orihuela, Maria-del-Carmen Prado-Uribe, Juan-Manuel Gallardo-Montoya, Bengt Lindholm
Summary: During peritoneal dialysis treatment with icodextrin solutions, females show higher levels of icodextrin metabolites in serum, which may lead to an increase in blood volume and blood pressure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Jose Emilio Sanchez, Catalina Ulloa, Carmen Merino Bueno, Elena Astudillo, Carmen Rodriguez-Suarez
Summary: The aim of this study was to evaluate the impact of PD strategy on technique and patient survival. The results showed that the use of APD and APD/icodextrin had a positive impact on patient survival, while age and Charlson Index had a negative impact. Age and early peritoneal infection also significantly impacted technique survival.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
David A. Jaques, Andrew Davenport
Summary: The study found that factors such as fast transport type, serum sodium levels, and diabetes were positively associated with sodium to water clearance, while PD mode and the use of 2.27% glucose dialysate were negatively associated. This indicates that CAPD, fast transport, and high serum sodium levels may allow more sodium to be removed compared to water.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Nutrition & Dietetics
Gordon Chun Kau Chan, Win Hlaing Than, Bonnie Ching Ha Kwan, Ka Bik Lai, Ronald Cheong Kin Chan, Jeremy Yuen Chun Teoh, Jack Kit Chung Ng, Kai Ming Chow, Phyllis Mei Shan Cheng, Man Ching Law, Chi Bon Leung, Philip Kam Tao Li, Cheuk Chun Szeto
Summary: This study found that miR-221 and miR-222 are associated with the progression of obesity, insulin resistance, and new onset diabetes mellitus (NODM) after peritoneal dialysis (PD).
Article
Cell Biology
Rebecca Herzog, Juan Manuel Sacnun, Guadalupe Gonzalez-Mateo, Maria Bartosova, Katarzyna Bialas, Anja Wagner, Markus Unterwurzacher, Isabel J. Sobieszek, Lisa Daniel-Fischer, Krisztina Rusai, Lucia Pascual-Anton, Klaus Kaczirek, Andreas Vychytil, Claus Peter Schmitt, Manuel Lopez-Cabrera, Seth L. Alper, Christoph Aufricht, Klaus Kratochwill
Summary: Adding lithium chloride to peritoneal dialysis fluid can improve mesothelial cell survival, reduce angiogenesis and fibrosis, and provide a translatable intervention to counteract peritoneal membrane deterioration during PD therapy. This study identified a potential therapeutic strategy in repurposing LiCl as a cytoprotective PDF additive to combat PD-induced mesothelial cytotoxicity.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jia Liu, Mingcheng Sun, Yong Xia, Xiaopei Cui, Jingjing Jiang
Summary: This study found that phloretin has a protective effect on renal damage in type 2 diabetes mellitus (T2DM) mice by preserving glomerular podocytes. Moreover, the therapeutic effect of phloretin is independent of blood glucose control and is potentially mediated by maintaining the expression levels of related proteins.
Article
Biochemistry & Molecular Biology
Chi-Chong Tang, Jen-Pi Tsai, Yi-Hsin Chen, Szu-Chun Hung, Yu-Li Lin, Bang-Gee Hsu
Summary: Disruptions in glucose metabolism are common among peritoneal dialysis (PD) patients, and impaired fasting glucose, insulin resistance, and PD glucose load are closely associated with aortic stiffness in PD patients without diabetes mellitus (DM).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Shamaila Rafiq, Per Bendix Jeppesen
Summary: The study revealed a correlation between vitamin D and insulin resistance, with individuals having higher levels of insulin resistance when deficient in vitamin D, in both non-diabetic and diabetic populations.
Review
Pharmacology & Pharmacy
Emily Blaine, Robin Tumlinson, Marion Colvin, Tyler Haynes, Heather P. Whitley
Summary: Chronically uncontrolled hyperglycemia is a common factor in end stage kidney disease (ESKD) that requires dialysis. However, there is a lack of clear clinical recommendations for adjusting insulin dosing during the transition to hemodialysis (HD) or peritoneal dialysis (PD).
Article
Nutrition & Dietetics
Cherlyn Ding, Leonie Egli, Nabil Bosco, Lijuan Sun, Hui Jen Goh, Khung Keong Yeo, Jonathan Jiunn Liang Yap, Lucas Actis-Goretta, Melvin Khee-Shing Leow, Faidon Magkos
Summary: The study found that plasma BCAA levels were associated with increased insulin secretion and decreased insulin clearance in healthy Chinese subjects. This suggests that BCAA may play an important role in the regulation of glucose homeostasis.
FRONTIERS IN NUTRITION
(2021)
Article
Medicine, General & Internal
Andras Bikov, Stefan M. Frent, Martina Meszaros, Laszlo Kunos, Alexander G. Mathioudakis, Alina Gabriela Negru, Laura Gaita, Stefan Mihaicuta
Summary: OSA is associated with increased insulin resistance, and the triglyceride-glucose index (TyG) has been found to be significantly higher in OSA patients, related to disease severity. However, further evaluation in non-obese, non-diabetic subjects is needed to determine the clinical significance of TyG in OSA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Kana Asari, Yukio Maruyama, Kyoko Kishida, Masatsugu Nakao, Nanae Matsuo, Yudo Tanno, Ichiro Ohkido, Masato Ikeda, Keitaro Yokoyama, Takashi Yokoo
Summary: This study aimed to compare the changes in peritoneal function and residual renal function during the first year of peritoneal dialysis (PD) treatment between diabetic and non-diabetic patients. The results showed that the ratio of dialysate to plasma creatinine (D/P Cr) increased in non-diabetics but did not significantly change in diabetic patients, especially among those using icodextrin. Diabetics with a higher peritoneal solute transport rate at PD initiation showed an attenuation within one year, with icodextrin playing a key role in improving body fluid status.
THERAPEUTIC APHERESIS AND DIALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Chia-Ning Chang, Chih-Yuan Niu, Ann Charis Tan, Chia-Hao Chan, Chun-Fan Chen, Tz-Heng Chen, Szu-Yuan Li, Yung-Tai Chen, Fan-Yu Chen, Wen-Sheng Li, Chih-Ching Lin, Guor-Jien Wei
Summary: This study investigated the impact of FIR therapy on dialysate GDPs and peritoneal function in diabetic patients on PD. The results showed that FIR therapy decreased GDPs in PD solutions, improved glucose transport rate, and maintained or increased peritoneal adequacy in both diabetic and non-diabetic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Hematology
Guido Filler, Aaron Haig, Neil Merritt, Ana Catalina Alvarez-Elias, Chia Wei Teoh, Timm Joachim Filler, Maria Esther Diaz-Gonzalez de Ferris
Summary: Peritoneal biopsies in pediatrics with long-term PD using physiological solutions showed significant histopathological changes, indicating that avoiding pH trauma may not completely ameliorate the effects of glucose exposure.
BLOOD PURIFICATION
(2022)
Article
Biochemistry & Molecular Biology
Imre Juhasz, Szilvia Ujfalusi, Ildiko Seres, Hajnalka Lorincz, Viktoria Evelin Varga, Gyoergy Paragh, Sandor Somodi, Mariann Harangi, Gyoergy Paragh
Summary: This study found that in non-diabetic, obese patients, Afamin levels were significantly higher and correlated with markers of metabolic syndrome. After multiple regression analysis, HbA1c levels and small HDL subfractions were identified as independent predictors of Afamin.
Review
Urology & Nephrology
Emma Elphick, Matthew Holmes, Matthew Tabinor, Yeoungjee Cho, Thu Nguyen, Tess Harris, Angela Yee Moon Wang, Arsh K. Jain, Daniela Ponce, Josephine S. F. Chow, Annie-Claire Nadeau-Fredette, Adrian Liew, Neil Boudville, Allison Tong, David W. Johnson, Simon J. Davies, Jeffrey Perl, Karine E. Manera, Mark Lambie
Summary: The study found substantial heterogeneity in how PD technique survival is defined and measured in different studies of patients receiving peritoneal dialysis, leading to considerable variability in reported rates. Standardised measures are needed to improve comparability in PD studies.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Murilo Guedes, Roberto Pecoits-Filho
Summary: Diabetic kidney disease (DKD) is a major cause of chronic kidney disease (CKD) worldwide, placing a significant burden on patient outcomes. Recent interventions and guidelines emphasize multidimensional approaches for optimal clinical management. Challenges lie in implementing these approaches to improve clinical outcomes and address residual risk in DKD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Letter
Urology & Nephrology
Murilo Guedes, Bruce Robinson, Brian Bieber, Roberto Pecoits-Filho
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Urology & Nephrology
Toby Humphrey, Mogamat Razeen Davids, Mogamat-Yazied Chothia, Roberto Pecoits-Filho, Carol Pollock, Glen James
Summary: This study provides a comprehensive overview of the epidemiology of hyperkalaemia, including its prevalence and incidence in different populations, healthcare settings, and continents. The prevalence of hyperkalaemia in adults is 6.3%, with an incidence of 2.8 cases per 100 person years. In the general population, the prevalence is 1.3%, with an incidence of 0.4 cases per 100 person years. Prevalence varies by sex and the definition/threshold used. Patients with end-stage kidney disease, kidney transplant patients, and patients with acute kidney injury have the highest prevalence of hyperkalaemia.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Urology & Nephrology
Carolina Aparecida de Almeida Vicentini, Daniela Ponce
Summary: This study compared the outcomes of peritoneal dialysis (PD) and hemodialysis (HD) patients and found that the survival rates were similar between the two groups. Higher age and shorter infection-free time were associated with death.
JORNAL BRASILEIRO DE NEFROLOGIA
(2023)
Article
Urology & Nephrology
Joao Victor Costa Muller, Daniela Ponce
Summary: This retrospective cohort study compared the infectious and mechanical complications in planned-start and urgent-start peritoneal dialysis (PD) patients. The study found no significant differences in the incidence of exit-site infection and peritonitis between planned-start and urgent-start PD patients, although the pathogens causing peritonitis were different. Leakage as a mechanical complication was more commonly seen in the urgent-start PD group. Patient survival and time on PD were similar between the two groups. Death was associated with lower albumin levels and older age, while peritonitis was associated with diabetes.
JORNAL BRASILEIRO DE NEFROLOGIA
(2023)
Article
Engineering, Biomedical
Cristine Naomi Ohara, Maria Irma Suarez, Koody Hassemi Kitawara, Welder Zamoner, Andre Luis Balbi, Daniela Ponce
Summary: This study investigated the prevalence of successful discontinuation of acute kidney replacement therapy (AKRT) and its predictive factors in adult patients with severe acute kidney injury (AKI). The study found that C-reactive protein, urine output, and the need for mechanical ventilation at the time of AKRT interruption were associated with discontinuation success. In addition, the absence of comorbidities such as chronic kidney disease, cardiovascular disease, and hypertension, as well as pH values at the time of AKRT indication, mechanical ventilation at the time of interruption, and successful discontinuation were identified as variables associated with hospital discharge.
Article
Urology & Nephrology
Marilia Mastrocolla de Almeida Cardoso, Juliana Machado-Rugolo, Silvana Andrea Molina Lima, Luis Gustavo Modelli de Andrade, Daniel da Silva Pereira Curado, Daniela Ponce
Summary: Based on a cost-effectiveness and budgetary impact analysis from the perspective of the Brazilian Public Health Care System (SUS), intravenous paricalcitol is more effective than oral calcitriol for treating secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD) on dialysis, reducing overall mortality despite higher costs.
JORNAL BRASILEIRO DE NEFROLOGIA
(2023)
Article
Nutrition & Dietetics
Maryanne Zilli Canedo Silva, Barbara Perez Vogt, Nayrana Soares Carmo Reis, Fernanda Chiuso Minicucci, Mariana Souza Dorna, Marcos Ferreira Minicucci, Jacqueline Costa Teixeira Caramori
Summary: This study assessed the association of serum myostatin with lean mass, physical function, and hospitalization in peritoneal dialysis (PD) patients.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Medicine, Research & Experimental
Bartholomeus J. A. Willigers, Mario Ouwens, Andrew Briggs, Hiddo J. L. Heerspink, Carol Pollock, Roberto Pecoits-Filho, Navdeep Tangri, Csaba P. P. Kovesdy, David C. C. Wheeler, Juan Jose Garcia Sanchez
Summary: To minimize uncertainty in projecting long-term outcomes in clinical trials, researchers developed a novel method that incorporates expert opinion in a Bayesian analysis. The results showed that using expert opinion in Bayesian analysis produced a smaller range of survival values compared to frequentist methods.
ADVANCES IN THERAPY
(2023)
Article
Urology & Nephrology
Daniela Ponce, Marilia Mastrocolla de Almeida Cardoso, Juliana Rodrigues Machado Rugolo, Silvana Andrea Molina, Luis Gustavo Modelli de Andrade, Daniel da Silva Pereira Curado
Summary: This study conducted a cost-effectiveness and budgetary impact analysis of cinacalcet compared to paricalcitol in the Brazilian market. The results showed that cinacalcet was more cost-effective in avoiding parathyroidectomies.
JORNAL BRASILEIRO DE NEFROLOGIA
(2023)
Article
Hematology
Camila Albuquerque Alves, Viviane Calice-Silva, Elaine Mari Rufino, Durval Garms, Helen Caroline Ferreira, Mariane Baptistella, Dayana Bitencourt Dias, Marcela Lara Mendes, Vanessa Burgini Banin, Daniela Ponce
Summary: The study assessed the Brazilian urgent-start PD program in three different dialysis centers. Results showed that PD is a feasible option that can help alleviate the shortage of hemodialysis beds.
BLOOD PURIFICATION
(2023)
Article
Urology & Nephrology
Murilo Guedes, Junhui Zhao, Brian LaMoreaux, Brad Marder, Barry Gorlitsky, Vinicius Domingues, Matthew B. Rivara, Susie Lew, Bruce Robinson, Roberto Pecoits-Filho, Angelo Karaboyas, Ali Alaradi, Pieter Evenepoel, Michel Jadoul, Manish Sood, Rita Suri, Xiaonong Chen, Yuqing Chen, Fanfan Hou, Xinling Liang, Zhaohui Ni, Li Zuo, Christian Combe, Fitsum Guebre-Egziabher, Pablo Antonio Urena Torres, Werner Kleophas, Elke Schaeffner, Thomas Weinreich, Giuliano Brunori, Loreto Gesualdo, Francesco Locatelli, Masafumi Fukagawa, Masaaki Inaba, Masaomi Nangaku, Kosaku Nitta, Kazuhiko Tsuruya, Saeed Al-Ghamdi, Mohammed Al Ghonaim, Fayez Hejaili, Ayman Karkar, Faissal Shaheen, Jamal Al Wakeel, Naser Alkandari, Anas Alyousef, Bassam Al Helal, Issa Alsalmi, Yacoub Al Maimani, Fadwa Al Ali, Abdulla Hamad, Aleix Cases, Almudena Vega Martinez, Patricia de Sequera, Anders Christensson, Stefan Jacobson, Samra Abouchacra, Mohamed Hassan, Ali Abdulkarim Al Obaidli, Mona Al Rukhaimi, Abdul Kareem Saleh, Elham Asgari, Indranil Dasgupta, Hugh Rayner, David Johnson, Jeffrey Perl, Mauricio Sanabria, Hideki Kawanishi, Yong-Lim Kim, Talerngsak Kanjanabuch, Simon Davies, Ronald Pisoni, Bruce Robinson, Jenny Shen
Summary: The prevalence of gout is high in patients with kidney disease and its association with outcomes in hemodialysis and peritoneal dialysis populations in North America is unknown.
Article
Urology & Nephrology
Luis Eduardo Magalhaes, Paula Gabriela Sousa de Oliveira, Ana Julia Favarin, Bruna Kaori Yuasa, Pedro Andriolo Cardoso, Welder Zamoner, Daniela Ponce
Summary: This study aimed to evaluate the incidence of acute kidney injury (AKI) in Brazilian hospitalized patients diagnosed with COVID-19 and identify the risk factors associated with its onset and prognosis. The study found that older age, mechanical ventilation, use of vasoactive drugs, and presence of proteinuria were risk factors for the development of AKI, which in turn increased the risk of mortality.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Letter
Urology & Nephrology
Vitoria Mori, Renan da Silva Neves, Amanda Gomes Pereira, Mariana de Souza Dorna, Nayane Maria Vieira, Maryanne Zilli Canedo da Silva, Taline Lazzarin, Hellen Christina Neves Rodrigues, Daniela Ponce, Andre Luis Balbi, Leonardo Antonio Mamede Zornoff, Paula Schmidt Azevedo, Bertha Furlan Polegato, Sergio Alberto Rupp de Paiva, Marcos Ferreira Minicucci, Nara Aline Costa
JOURNAL OF NEPHROLOGY
(2023)