Article
Biotechnology & Applied Microbiology
Rory Gibney, Eleonora Ferraris
Summary: The study utilized aerosol jet printing to process collagen type I and II into dense constructs with suitable mechanical properties for replicating dense collagenous connective tissues. Collagen type II exhibited lower viscosity compared to type I, and both types experienced a drop in viscosity due to aerosol jet printing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Saeed Hatefi Ardakani, Peyman Fatemi Dehaghani, Hesam Moslemzadeh, Soheil Mohammadi
Summary: The study aims to analyze the mechanical behavior of the arterial wall in the degraded region, determining stress distribution and potential failure mechanisms. A 3D multiscale technique based on homogenization and genetic algorithm is used to model collagen fiber degradation. The study finds that collagen fiber degradation leads to thinning of the arterial wall and increased stress on the inner surface, making it more prone to failure.
ENGINEERING COMPUTATIONS
(2022)
Article
Biochemical Research Methods
Enrui Zhang, Bart Spronck, Jay D. Humphrey, George Em Karniadakis
Summary: We introduce G phi Fnet, a novel scientific machine learning approach that enables a better quantification of clinically important macroscale biomechanical properties of tissues and a direct association with an underlying genetic mutation. G phi Fnet can capture the genotype-dependent biomechanical properties of soft tissues by utilizing limited, noisy, and unstructured data from experiments. The learned constitutive relation is robust to small data, and generalizable to unseen tissue. G phi Fnet provides a powerful tool for understanding relationships between genotype and biomechanical phenotype in biological tissues, promising great potential in soft tissue mechanics, mechanobiology, and related clinical applications.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Physics, Multidisciplinary
Michele Furlani, Nicole Riberti, Marta Di Nicola, Alessandra Giuliani
Summary: Mechanical stimuli not only regulate cells but also affect the extracellular matrix activity, such as the composition, amount, and distribution of collagen bundles. By using synchrotron-based phase-contrast computed tomography, collagen bundles can be resolved in 3D in various body areas. This study demonstrates that deep learning semantic image segmentation can better identify and classify collagen bundles compared to conventional thresholding segmentation techniques.
FRONTIERS IN PHYSICS
(2023)
Article
Computer Science, Interdisciplinary Applications
Francisco P. A. Almeida, Antonella Cecchi
Summary: This paper introduces the newly developed MSG technique as an alternative for homogenizing masonry, with comparisons to traditional methods in numerical analyses. The results show that MSG is closer to FEM for unreinforced masonry and can increase stiffness for reinforced masonry, particularly in the horizontal direction. The advantages of MSG over FEM for masonry homogenization process are also highlighted.
COMPUTERS & STRUCTURES
(2021)
Article
Mechanics
Md Hafijur Rahman, Suprabha Islam, Sunghwa Yang, Chun Il Kim
Summary: A continuum model is proposed to analyze the mechanical response of elastic solid reinforced with randomly distributed nanofibers. The kinematics of embedded nanofibers are derived using the shear lag parameter and the Krenchel Orientation factor in the second strain-gradient model. The numerical solutions of nonlinear coupled differential equations are obtained using a custom-built finite element analysis scheme. The simulation results show that the fiber aspect ratio and the third gradient constitutive parameter influence the effective Young's modulus of the third gradient continua.
Article
Materials Science, Textiles
Juan Leon-Becerra, Claudia Tavera-Ruiz, Julio Galvis-Chacon
Summary: Biocomposite materials are sustainable alternatives to traditional composites, offering lower carbon footprint and cost while maintaining similar features. This study investigates the effect of raw material acquisition on the mechanical behavior of a woven biocomposite material, specifically using fique (Furcraea Andina) as reinforcement. Geometric characterization and numerical simulations were used to determine the distribution of variables and their impact on the biocomposite's mechanical properties, revealing significant scatter due to the textile's geometrical imperfections.
FIBERS AND POLYMERS
(2023)
Article
Engineering, Mechanical
Zhizhou Zhang, Jeong-Ho Lee, Grace X. Gu
Summary: This study explores the physical origin of electro-momentum coupling by employing a high throughput sweep over the microstructure design space of a piezoelectric composite system, and demonstrates how material constituent properties and geometrical arrangements can affect electro-momentum coupling.
EXTREME MECHANICS LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Gianfranco Ulian, Daniele Moro, Giovanni Valdre
Summary: Hard tissues in vertebrates, such as bone and enamel, are complex materials controlled by physical and chemical interactions between collagen and hydroxylapatite-like mineral. Atomistic computer simulations have proven to be valuable tools for understanding the properties of bony and dental tissues at the atomic scale, aiding in the development of specific biomaterials. The computational approach shows promise in dealing with complex biological physicochemical systems and expanding knowledge in hard tissue science.
Article
Materials Science, Composites
Nada Ben-Ltaief, Franck NGuyen, Toufik Kanit, Abdellatif Imad, Nizar Bel-Hadj-Ali
Summary: Seashell waste, composed of calcium carbonate and a complex microstructure, is increasingly used as a bio-filler for composite materials. This study investigates the effect of particle size, shape, and inter-phase properties on the elastic properties of seashell particle-reinforced bio-composites. The results show that the addition of seashell particles significantly improves the elastic properties of the composites, while seashell particle morphology and inter-phase structure have a negligible effect. However, the inter-phase thickness has a considerable impact on the elastic properties of the bio-composites.
JOURNAL OF COMPOSITE MATERIALS
(2023)
Article
Chemistry, Physical
Amadeus C. S. Alcantara, Levi C. Felix, Douglas S. Galvao, Paulo Sollero, Munir S. Skaf
Summary: This paper presents a detailed prescription for designing all-atom bone molecular models at the nanoscale, which include hydroxyapatite in both the intra-fibrillar volume and the extra-fibrillar volume, resembling fibers in bones. The models were validated through molecular dynamics simulations and compared with literature results.
Article
Engineering, Aerospace
Mehdi Ranjbar-Roeintan
Summary: The purpose of this article is to investigate the porosity-dependent impact study of a plate with Winkler-Pasternak elastic foundations reinforced with agglomerated carbon nanotubes (CNTs). By using the first-order shear deformation plate theory, the strain energy related to elastic foundations is added to system strain energy. Nonlinear and time-dependent motion equations are obtained using separation of variables and Lagrangian generalized equations. Verification examples are fulfilled to prove the precision and effectiveness of the presented model. The impact outputs illustrate the effects of various distribution of CNTs porosity functions along the plate thickness direction, Winkler-Pasternak elastic foundations and different boundary conditions on the Hertz contact law, the plate center displacement, impactor displacement and impactor velocity.
AIRCRAFT ENGINEERING AND AEROSPACE TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
M. M. Shahzamanian, S. S. Akhtar, A. F. M. Arif, W. J. Basirun, K. S. Al-Athel, M. Schneider, N. Shakelly, Abbas Saeed Hakeem, Abba A. Abubakar, P. D. Wu
Summary: This study presents a novel material design framework based on a multi-scale modeling approach to improve the mechanical and thermal properties of ceramic cutting tools using nickel-reinforced alumina composites. The effectiveness of the framework is validated through computational homogenization methods and experimental results, and the effects of porosity and nickel volume fraction on the properties are investigated.
SCIENTIFIC REPORTS
(2022)
Article
Construction & Building Technology
Alaa A. Abdelrahman, Rabab A. Shanab, Ismail Esen, Mohamed A. Eltaher
Summary: This manuscript investigates the dynamic response of nanoscale carbon nanotubes embedded in an elastic media under moving load using doublet mechanics theory. The size effect of the nanotubes is captured by simulating nano-mechanics through a bottom-up approach. Different configurations of the nanotubes are considered, and the influence of these configurations on the dynamic behavior is explored. The accuracy of the developed procedure is verified by comparing the results with previous algorithms, showing good agreement.
STEEL AND COMPOSITE STRUCTURES
(2022)
Article
Multidisciplinary Sciences
Liu Chu, Jiajia Shi, Eduardo Souza de Cursi
Summary: In this paper, correlations between characteristic parameters of graphene and resonant frequencies were analyzed using a Monte Carlo based stochastic finite element model. The uncertainty in the characteristic parameters was properly propagated and quantified through the Monte Carlo stochastic sampling procedure. The study also discussed the robustness of stochastic samples based on statistical records and probability density distributions, while calculating and comparing the Pearson and Spearman correlation coefficients of the corresponding characteristic parameters.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Michele Marino, Giuseppe Vairo, Peter Wriggers
Summary: This review emphasizes the urgent priorities in the field of computational biomechanics, introducing new methods and challenges for computational modeling of arterial tissues in health and disease, and encouraging interdisciplinary efforts.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Editorial Material
Engineering, Biomedical
Luca Cristofolini, Michele Marino, Giulia Luraghi, Marco Palanca
MEDICAL ENGINEERING & PHYSICS
(2021)
Article
Biophysics
Meike Gierig, Peter Wriggers, Michele Marino
Summary: Healing in soft biological tissues involves a complex interplay of mechanical, chemical, and biological aspects, with molecular-level damage in collagen serving as a crucial initiator for the healing process. The proposed computational framework successfully captures and integrates these multifaceted mechanisms, providing a basis for detailed simulations of tissue response to damage. The model demonstrates the evolutions of growth factors and matrix metalloproteinases following damage and subsequent growth and remodeling processes, highlighting the significance of mechanical and chemo-biological events during healing.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Engineering, Multidisciplinary
Christoph Boehm, Blaz Hudobivnik, Michele Marino, Peter Wriggers
Summary: This work presents a study on the computational homogenization of electro-magneto-mechanically coupled problems through the Virtual Element Method (VEM), showing that VEM outperforms FE for all considered materials. Additionally, a hybrid microstructure made up by both electro-mechanical and magneto-mechanical grains is investigated resulting in an electro-magneto-mechanically coupled microstructure where VEM provides a more accurate solution strategy.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2021)
Article
Materials Science, Multidisciplinary
Aidin Hajikhani, Peter Wriggers, Michele Marino
Summary: Hydrogels are mechanically stabilized through induced crosslinking in the polymer network by external agents, but monitoring crosslinking kinetics with sufficient resolution is currently lacking. A new thermodynamically consistent chemo-mechanical model has been proposed to study reactive-diffusive mechanisms in alginate hydrogels, allowing for investigation of hydrogels' behavior and characterization of mechano-chemical properties. The model reveals a two-way coupling between mechanics and chemistry, showing the importance of internal stresses on crosslinking kinetics.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2021)
Article
Engineering, Mechanical
Jorge-Humberto Urrea-Quintero, Jan N. Fuhg, Michele Marino, Amelie Fau
Summary: An innovative numerical strategy is proposed to estimate stabilizing sets of PI or PID controllers for tackling nonlinear systems, by using an adaptive surrogate algorithm to explore the controller parameters' domain and classify them into stable/unstable regions from a low number of nonlinear estimations.
NONLINEAR DYNAMICS
(2021)
Article
Engineering, Multidisciplinary
Jan N. Fuhg, Michele Marino, Nikolaos Bouklas
Summary: This paper introduces a method that combines data-driven constitutive prediction and macroscopic calculations, ensuring prediction accuracy and reliability by using local approximate Gaussian process regression (laGPR). A modified Newton-Raphson approach specific to laGPR is proposed to solve the global structural problem.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2022)
Article
Polymer Science
Bastien Sauty, Gianluca Santesarti, Tabea Fleischhammer, Patrick Lindner, Antonina Lavrentieva, Iliyana Pepelanova, Michele Marino
Summary: This research introduces a method for manufacturing GelMA-based hydrogel constructs with desired stiffness gradients using dynamic mixing and passive micromixer technologies, along with a digital replica of the fabrication process integrating theoretical and experimental data to predict and control stiffness profiles. The in silico framework has been validated and used for optimizing process variables to achieve a linear stiffness profile, eliminating the need for costly and time-consuming trial-and-error procedures, serving as a powerful tool for tissue engineering applications and optimal 3D cell culture conditions screening.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2022)
Article
Mechanics
Pierfrancesco Gaziano, Cristina Falcinelli, Giuseppe Vairo
Summary: This paper addresses femur failure mechanics through numerical simulations, investigating the influence of different descriptions of bone constitutive behavior, failure criteria, and ultimate parameters on yield and failure load. The results suggest that an elastic quasi-brittle bone description combined with strain-based failure criteria is more effective in predicting the mechanical behavior and fracture patterns of femurs.
EUROPEAN JOURNAL OF MECHANICS A-SOLIDS
(2022)
Article
Nuclear Science & Technology
Lorenzo Zoboli, Antonio della Corte, Giuseppe Vairo
Summary: This paper investigates the effectiveness of reduced-order models in analyzing the mechanical response of Toroidal Field Coils (TFC) when non-ideal shapes are considered. Different beam models, based on different treatments of shear and bending effects, are introduced. A bottom-up homogenization technique is used to account for the subscale arrangement of TFC components, providing quantitative indications on average localisation effects. The beam-like approaches are validated by comparing with detailed finite element models, showing their reliability in preliminary design stages.
FUSION ENGINEERING AND DESIGN
(2022)
Article
Engineering, Electrical & Electronic
L. Zoboli, A. Anemona, A. Di Zenobio, L. Giannini, L. Muzzi, G. Romanelli, S. Turtu, G. Vairo, A. della Corte
Summary: This article discusses the design choices of the PF coil system in the DTT and the interactions among the TF coils, PF supports, and PF magnets.
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY
(2022)
Article
Materials Science, Multidisciplinary
Pierfrancesco Gaziano, Elisabetta Monaldo, Cristina Falcinelli, Giuseppe Vairo
Summary: In this paper, a multiscale modelling strategy is used to analyze the elasto-damage response of osteons, providing a refined mechanical description of cortical bone tissue. The structural features of osteons and the equivalent mechanical response of their constituents are described. Finite-element techniques are used to simulate the experimental tests of isolated osteons under different loading conditions.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2022)
Article
Biology
Meike Gierig, Peter Wriggers, Michele Marino
Summary: This work presents a continuum model and its in silico implementation that describe the cascade of mechanisms leading to tissue healing, coupling mechanical as well as chemo-biological processes. The proposed model combines a high number of chemo-mechano-biological mechanisms in a consistent continuum biomechanical framework. The features and applicability of the model are demonstrated through numerical examples.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Mechanics
Jan Niklas Fuhg, Amelie Fau, Nikolaos Bouklas, Michele Marino
Summary: By integrating machine learning techniques, a data-driven correction term is added to a phenomenological yield model, enhancing its performance in plasticity formulation. Similar results can be obtained using Support Vector Regression, Gaussian Process Regression, and Neural Networks, ensuring the convexity of the model-data yield functions. A highly anisotropic yield response with tension/compression asymmetries can be successfully reproduced by incorporating a limited number of synthetic data points.
EUROPEAN JOURNAL OF MECHANICS A-SOLIDS
(2023)
Meeting Abstract
Cell & Tissue Engineering
Gianluca Santesarti, Michele Marino, Francesco Viola, Roberto Verzicco, Giuseppe Vairo
TISSUE ENGINEERING PART A
(2022)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)
