Review
Materials Science, Multidisciplinary
Arman Jafari, Zineb Ajji, Ali Mousavi, Saman Naghieh, Sidi A. Bencherif, Houman Savoji
Summary: Cardiovascular diseases are a major cause of global mortality, and transplantation remains the gold standard for treatment. Tissue engineering and 3D bioprinting have shown promising results in cardiac regeneration. Researchers are exploring new strategies utilizing 3D bioprinting for cardiac tissue regeneration, with a focus on precision and complexity.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Biochemistry & Molecular Biology
Naima Niazy, Mareike Barth, Jessica I. Selig, Sabine Feichtner, Babak Shakiba, Asya Candan, Alexander Albert, Karlheinz Preuss, Artur Lichtenberg, Payam Akhyari
Summary: Calcific aortic valve disease is the most common valvular heart disease in industrialized countries, and this study aimed to establish an ex vivo model to analyze aortic valve degeneration under controlled physiological conditions. Ovine aortic roots bearing aortic valve leaflets were cultivated in a bioreactor system with pulsatile flow, leading to shrinking and thickening of the valve leaflets compared to native leaflets. Degenerative conditions induced considerable leaflet calcification, and collagen gene expression was stable under bioreactor cultivation.
Review
Biotechnology & Applied Microbiology
Sunita Brimmer, Pengfei Ji, Aditya K. Birla, Sundeep G. Keswani, Christopher A. Caldarone, Ravi K. Birla
Summary: The field of biological pumps focuses on the development of tubular grafts that generate intraluminal pressure. They can be used in cardiac tissue engineering and have applications as standalone devices. Many fabrication technologies and materials have been tested, and bioreactors have been used to replicate the in vivo environment. This article provides an overview of the field, discussing progress, fabrication methods, biomaterial platforms, and challenges.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Raphael F. Canadas, Ziyu Liu, Luca Gasperini, Diogo C. Fernandes, Fatima R. Maia, Rui L. Reis, Alexandra P. Marques, Chaozong Liu, Joaquim M. Oliveira
Summary: In this study, a compartmentalized rotational 3D cell culture platform is proposed for simulating gradient tissue culture conditions. Controlled flow dynamics are used to enable tissue stratification. The platform improves cell culture viability and construct maturation, and has broad applications in tissue engineering and drug discovery/screening.
Review
Biochemistry & Molecular Biology
Jianhua Zhang, Esther Wehrle, Marina Rubert, Ralph Mueller
Summary: Three-dimensional (3D) bioprinting is a promising approach for tissue engineering, allowing precise placement of cells and biomaterials to mimic complex microstructures of biological tissues. Bioprinted tissues can benefit from exposure to fluid mechanical cues provided by bioreactor systems, aiding in tissue development and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Suruk Udomsom, Apiwat Budwong, Chanyanut Wongsa, Pakorn Sangngam, Phornsawat Baipaywad, Chawan Manaspon, Sansanee Auephanwiriyakul, Nipon Theera-Umpon, Pathinan Paengnakorn
Summary: This paper presents the development of a programmable bioreactor and a novel pH sensor, and demonstrates their potential applications in cell culture.
BIOENGINEERING-BASEL
(2022)
Article
Polymer Science
Laura Rojas-Rojas, Maria Laura Espinoza-Alvarez, Silvia Castro-Piedra, Andrea Ulloa-Fernandez, Walter Vargas-Segura, Teodolito Guillen-Giron
Summary: Tissue engineering aims to develop in-vitro substitutes of native tissues, and one approach is using bioreactors combined with biomimetic scaffolds. This study demonstrated that a collagen-coated microfilament scaffold seeded with C2C12 myoblasts inside a custom-built bioreactor provided a promising structure for the study of skeletal muscle models. The findings have important implications for mechanical stimulation studies in tissue engineering applications.
Article
Biochemical Research Methods
Gordian Born, Evelia Plantier, Guido Nannini, Alessandro Caimi, Andrea Mazzoleni, M. Adelaide Asnaghi, Manuele G. Muraro, Arnaud Scherberich, Ivan Martin, Andres Garcia-Garcia
Summary: Bioreactors that allow direct perfusion of cell suspensions or culture media through 3D scaffolds are widely used in tissue engineering to improve cell seeding efficiency, uniformity of cell distribution, and tissue development. A macro-scale U-shaped bioreactor has been previously developed, but the perfusion flow in the peripheral regions was not uniform. In this study, the design of the perfusion chamber has been optimized to provide more homogeneous perfusion flow through the scaffold. Furthermore, a miniaturized version of the flow-optimized bioreactor has been proposed for medium-throughput assays.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Elisa Capuana, Simona Campora, Giorgio Catanzaro, Francesco Lopresti, Gioacchino Conoscenti, Giulio Ghersi, Vincenzo La Carrubba, Valerio Brucato, Francesco Carfi Pavia
Summary: Perfusion of flow during cell culture promotes cell proliferation and enhances cellular activity. Numerical simulations and micro-computed tomography were used to evaluate the effects of operating parameters of a custom-made bioreactor and the porous microstructure of scaffolds on fluid flow and cell viability. The results showed a uniform distribution of liquid velocities and confirmed the importance of flow uniformity for successful perfusion cultures.
BIOCHEMICAL ENGINEERING JOURNAL
(2023)
Article
Computer Science, Interdisciplinary Applications
Concepcion Paz, Eduardo Suarez, Christian Gil, Oscar Parga
Summary: The traditional methods for repairing damaged bones have limitations, leading to the rise of bone tissue engineering and osteogenic implants as promising solutions. Designing three-dimensional scaffolds to promote tissue regeneration and bone formation is challenging, with randomized trabecular scaffolds showing superior performance in cell growth.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Lisa Sassi, Omolola Ajayi, Sara Campinoti, Dipa Natarajan, Claire McQuitty, Riccardo Rayan Siena, Sara Mantero, Paolo De Coppi, Alessandro F. Pellegata, Shilpa Chokshi, Luca Urbani
Summary: Decellularised organ scaffolds in the field of in vitro liver disease models maintain original properties, but the scarcity of appropriate bioreactors hampers tissue engineering approaches. A novel specific bioreactor was designed for long-term 3D culture of whole liver constructs, supporting cell survival and function. The bioreactor allows non-invasive monitoring and analysis of bioengineered constructs, showing higher viability, distribution, and functionality under dynamic conditions compared to static culture.
Review
Chemistry, Multidisciplinary
Dannielle M. Cox-Pridmore, Fernando A. Castro, S. Ravi P. Silva, Patrizia Camelliti, Yunlong Zhao
Summary: Heart diseases are the leading cause of death worldwide. Recent developments in bioelectronics offer the potential to overcome limitations in cardiovascular tissue engineering and produce physiologically relevant tissue for cardiovascular research and medicine. This review highlights the advances in cardiovascular-based bioelectronics, including discussions on bioelectronic therapies, advantageous materials, and interface models for in vitro and in vivo applications.
Article
Biochemistry & Molecular Biology
Shuai Wang, Hazwani Suhaimi, Mostafa Mabrouk, Stella Georgiadou, John P. Ward, Diganta B. Das
Summary: This research focused on the effects of pore morphology on nutrient transport behavior in hollow fiber membrane bioreactors using different electrospun PCL scaffolds. The study showed a negative linear relationship between glucose diffusivities across PCL scaffolds and minimum glucose concentrations, indicating that scaffolds with higher diffusivities lead to improved glucose consumption efficiency. The results are expected to aid in optimizing HFMB designs and conducting more accurate upscaling analyses for bioreactors.
Article
Biochemistry & Molecular Biology
Aurelia Poerio, Bertrand Guibert, Melanie M. Leroux, Joao F. Mano, Franck Cleymand, Jean-Philippe Jehl
Summary: Myocardial infarction can cause irreversible damage to the heart muscle. Using 3D printing and a biomaterial ink, a study developed patterned anisotropic membranes that mimic the fibrillar structure of the myocardium, which could be used as cardiac patches for treatment and prevention of complications. A numerical model was also developed to predict the elastic properties of different geometries with tunable elasticity that can match the mechanical properties of the heart tissue.
Article
Nanoscience & Nanotechnology
Sophia Szymkowiak, Nathan Sandler, David L. Kaplan
Summary: Chronic kidney disease and kidney failure are increasing globally, with a lack of corresponding improvement in available therapies. Using silk fibroin protein scaffolds to support kidney cells can mimic the structure of the kidney and support a larger number of cells with more even distribution under perfused conditions.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Education & Educational Research
David Roy Warriner, Martin Bayley, Yubing Shi, Patricia Victoria Lawford, Andrew Narracott, John Fenner
BMC MEDICAL EDUCATION
(2017)
Article
Biology
Yubing Shi, Theodosios Korakianitis
COMPUTERS IN BIOLOGY AND MEDICINE
(2018)
Article
Engineering, Biomedical
Yubing Shi, Patricia V. Lawford, D. Rodney Hose
ANNALS OF BIOMEDICAL ENGINEERING
(2010)
Review
Engineering, Biomedical
Yubing Shi, Patricia Lawford, Rodney Hose
BIOMEDICAL ENGINEERING ONLINE
(2011)
Article
Computer Science, Interdisciplinary Applications
Yubing Shi, Yuhui Shi, Theodosios Korakianitis
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2011)
Article
Computer Science, Interdisciplinary Applications
Alistair Graham Brown, Yubing Shi, Andreas Arndt, Joerg Mueller, Patricia Lawford, David Rodney Hose
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2012)
Article
Engineering, Biomedical
David C. Barber, Isra Valverde, Yubing Shi, Alistair Brown, Philipp Beerbaum, D. Rodney Hose
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2014)
Article
Biophysics
Alistair G. Brown, Yubing Shi, Alberto Marzo, Cristina Staicu, Isra Valverde, Philipp Beerbaum, Patricia V. Lawford, D. Rodney Hose
JOURNAL OF BIOMECHANICS
(2012)
Review
Computer Science, Interdisciplinary Applications
J. Weese, A. Groth, H. Nickisch, H. Barschdorf, F. M. Weber, J. Velut, M. Castro, C. Toumoulin, J. L. Coatrieux, M. De Craene, G. Piella, C. Tobon-Gomez, A. F. Frangi, D. C. Barber, I. Valverde, Y. Shi, C. Staicu, A. Brown, P. Beerbaum, D. R. Hose
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2013)
Article
Multidisciplinary Sciences
David R. Warriner, Alistair G. Brown, Susheel Varma, Paul J. Sheridan, Patricia Lawford, David R. Hose, Abdallah Al-Mohammad, Yubing Shi
Article
Biology
Yubing Shi, Alistair G. Brown, Patricia V. Lawford, Andreas Arndt, Peter Nuesser, D. Rodney Hose
Article
Cardiac & Cardiovascular Systems
Yubing Shi, Israel Valverde, Patricia V. Lawford, Philipp Beerbaum, D. Rodney Hose
JOURNAL OF CARDIOLOGY
(2019)
Article
Biophysics
Yubing Shi, Israel Valverde, Patricia V. Lawford, Heynric B. Grotenhuis, Philipp Beerbaum, D. Rodney Hose
Summary: Non-invasive estimation of pressure gradient in cardiovascular stenosis is crucial for assisting diagnosis and treatment. Through a systematic comparison, one of the improved models proposed in this research demonstrates the best prediction accuracy among the models studied.
JOURNAL OF BIOLOGICAL PHYSICS
(2021)
Article
Biophysics
Yubing Shi, Theodosios Korakianitis, Christopher Bowles
JOURNAL OF BIOMECHANICS
(2007)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)
