Article
Biophysics
Alastair R. J. Quinn, David J. Saxby, Fuwen Yang, Ana C. C. de Sousa, Claudio Pizzolato
Summary: Medical device regulatory standards are incorporating computational modelling and simulation. A method for testing soft tissue products using a digital twin paradigm and robotic systems is presented. The accuracy of the digital twin in reproducing experimental data improved after calibration.
JOURNAL OF BIOMECHANICS
(2023)
Article
Green & Sustainable Science & Technology
G. Barone, A. Buonomano, C. Forzano, G. F. Giuzio, A. Palombo, G. Russo
Summary: Indoor thermal comfort is an important aspect of building design. The existing standards fail to consider the thermal adaptability of the human body, leading to misleading energy consumption and system sizing. To address these issues, a physiological thermal comfort model is developed to evaluate the dynamic variation of physiological parameters and occupants' thermal sensation. This model is implemented in a building energy simulation tool to propose dynamic control strategies for thermo-hygrometric parameters and heating/cooling demands, resulting in higher energy consumption but improved comfort for occupants compared to traditional set-point values.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Article
Orthopedics
Nathan C. Ho, Colin P. McCarty, Sang-Hyun Park, Joan R. Williams, Neda F. Gilmartin, Edward Ebramzadeh, Sophia N. Sangiorgio
Summary: The study conducted load-controlled testing on cadaveric specimens to evaluate total ankle replacements, revealing variations in anterior-posterior displacement and axial rotation among specimens but without exceeding the specified limits by ISO standards.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Review
Engineering, Biomedical
Chengfei Liu, Caiping Liu, Yang Bai, Jingxia Wang, Wei Tian
Summary: Drug self-delivery systems (DSDSs) offer new ways to create novel drug delivery systems (DDSs) by utilizing therapeutic reagents as active delivery agents. This review focuses on the recent advances and future trends in covalent and noncovalent bond-based DSDSs, discussing various chemical and architectural designs, fabrication strategies, and responsive and functional features. The potential applications of molecular designs in DSDSs are also presented, highlighting the promising potential of DSDSs in biological applications and their relationship with therapeutic effects.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Zoology
Birk Rillich, Fabio G. L. Oliveira
Summary: This study focuses on the jumping mechanism of springtails, and finds that the retinaculum and dens lock interact in a key-lock relationship, which is likely achieved through muscle force rather than hemolymph pressure. The study also reconstructs and explains the basic structure and function of the retinaculum and dens lock.
FRONTIERS IN ZOOLOGY
(2023)
Article
Automation & Control Systems
S. Mohanapriya, R. Sakthivel, Dhafer J. Almakhles
Summary: The focus of current research is to address the problem of robust output tracking, input delay compensation, and disturbance attenuation performance for a family of stochastic systems by implementing the improved equivalent input disturbance estimator and the extended Smith predictor technique. A new closed-loop configuration is presented by integrating the observer and IEID estimator with ESP. The Lyapunov based mean-square asymptotic stability criterion is obtained, and based on this criterion, an IEID and ESP-based controller is designed to guarantee exact output tracking. Simulation studies and comparisons with existing results demonstrate the effectiveness of the established control procedure.
Article
Automation & Control Systems
Xinwei Liu, Jinhui Zhang, Yuanqing Xia
Summary: This paper discusses the co-design technique of quantization and event-driven control to reduce the negative impacts of the network on the system performance of NCSs. By combining event-driven strategy and signal quantization, quantized event-driven control approaches are established for both fixed and relative event threshold cases, with analysis done on system stability and the existence of minimum interevent intervals (MIEI). The validity of the proposed approaches is demonstrated through numerical simulations.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2021)
Review
Evolutionary Biology
Sergio F. Vizcaino, M. Susana Bargo
Summary: The relationship between form and function has been a fascinating field of study in natural sciences, with different scholars from creationists in the 19th century to modern adaptation researchers in the 20th century exploring and analyzing this connection. Significant contributions by scholars in different periods have laid the foundation for modern form-function studies and development.
JOURNAL OF MAMMALIAN EVOLUTION
(2021)
Article
Thermodynamics
Martin Burston, Kavindu Ranasinghe, Alessandro Gardi, Vladimir Parezanovic, Rafic Ajaj, Roberto Sabatini
Summary: The integration of advanced distributed propulsion systems in aircraft configurations has the potential to enhance aircraft performance, reduce fuel consumption and emissions, and decrease take-off field length requirements. This involves the application of modern technologies to control and optimize the aerodynamic characteristics of the aircraft.
Article
Engineering, Biomedical
N. Pien, Y. Van de Maele, L. Parmentier, M. Meeremans, A. Mignon, C. De Schauwer, I. Peeters, L. De Wilde, A. Martens, D. Mantovani, S. Van Vlierberghe, P. Dubruel
Summary: A targeted solution for flexor tendon repair was developed in this study by combining mechanical and biological approaches. The developed repair constructs showed the required mechanical properties for tendon repair and the incorporated bioactive compounds were non-cytotoxic.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2022)
Review
Agricultural Engineering
Nitin Kumar Singh, Manish Yadav, Vijai Singh, Hirendrasinh Padhiyar, Vinod Kumar, Shashi Kant Bhatia, Pau-Loke Show
Summary: Artificial intelligence (AI) and machine learning (ML) are currently being used in multiple domains, including the monitoring and design of biological wastewater treatment systems (WWTS). This paper reviews the available information on the applications of AI and ML models in WWTS, presenting bibliometric analyses, model descriptions, specific applications, and major findings. Predominantly used models in biological wastewater treatment include artificial neural networks (ANN), fuzzy logic (FL) algorithms, random forest (RF), and long short-term memory (LSTM), which are tested for predictive control of effluent parameters such as biological oxygen demand (BOD), chemical oxygen demand (COD), nutrient parameters, solids, and metallic substances. Commonly used model performance indicators for accuracy analysis include root mean squared error (RMSE), mean square error (MSE), and determination coefficient (DC). Additionally, this study summarizes the outcomes of various models.
BIORESOURCE TECHNOLOGY
(2023)
Article
Automation & Control Systems
Yvonne R. Stuerz, Annika Eichler, Roy S. Smith
Summary: This article presents scalable controller synthesis methods for heterogeneous and partially heterogeneous systems, utilizing techniques from robust and gain-scheduled controller synthesis and proposing a distributed method for solving decomposition synthesis conditions. The introduction of a new system classification improves the compactness of formulating interconnected system models and synthesis conditions, while the computational scalability of the methods is analyzed and demonstrated in numerical examples.
IEEE TRANSACTIONS ON AUTOMATIC CONTROL
(2021)
Article
Automation & Control Systems
Andrea Rueetschi, Panagiotis Syrpas, Bartlomiej Flak, Kamil Tomzik, Peter K. Steimer
Summary: This article introduces a codesign workflow and a runtime architecture for digitally controlled switch-mode power conversion systems. By using a combination of multicore application processors and FPGAs in a general-purpose SoC, along with high-level synthesis, multirate control algorithms can be deployed and executed in real-time.
IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS
(2022)
Review
Chemistry, Multidisciplinary
Rui Huang, David C. Luther, Xianzhi Zhang, Aarohi Gupta, Samantha A. Tufts, Vincent M. Rotello
Summary: This review discusses the methods of functionalizing nanoparticles with small organic ligands to engineer NPs for nanobiology and nanomedicine.
Article
Biology
Christopher J. Mayerl, Kendall E. Steer, Almasi M. Chava, Laura E. Bond, Chloe E. Edmonds, Francois D. H. Gould, Tobin L. Hieronymous, Christopher J. Vinyard, Rebecca Z. German
Summary: This study used an infant pig model to investigate the contractile characteristics and line of action changes of four hyoid muscles during swallowing. It was found that as the hyoid bone elevated, the line of action of the attached muscles became greater in depression, and the muscles exhibited both eccentric and concentric contractions correlated with hyoid movement. This contributes to our understanding of muscle function during swallowing.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Austin J. Cocciolone, Jie Z. Hawes, Marius C. Staiculescu, Elizabeth O. Johnson, Monzur Murshed, Jessica E. Wagenseil
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Russell H. Knutsen, Scott C. Beeman, Thomas J. Broekelmann, Delong Liu, Kit Man Tsang, Attila Kovacs, Li Ye, Joshua R. Danback, Anderson Watson, Amanda Wardlaw, Jessica E. Wagenseil, Joel R. Garbow, Michael Shoykhet, Beth A. Kozel
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2018)
Article
Anatomy & Morphology
M. Gabriela Espinosa, Larry A. Taber, Jessica E. Wagenseil
DEVELOPMENTAL DYNAMICS
(2018)
Article
Biophysics
Kellie V. Stoka, Justine A. Maedeker, Lisa Bennett, Siddharth A. Bhayani, William S. Gardner, Jesse D. Procknow, Austin J. Cocciolone, Tezin A. Walji, Clarissa S. Craft, Jessica E. Wagenseil
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2018)
Article
Biophysics
Austin J. Cocciolone, Elizabeth O. Johnson, Jin-Yu Shao, Jessica E. Wagenseil
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2019)
Article
Biophysics
Jessica E. Wagenseil
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Chien-Jung Lin, Marius C. Staiculescu, Jessica Wagenseil, Robert P. Mecham
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Biophysics
Jungsil Kim, Austin J. Cocciolone, Marius C. Staiculescu, Robert P. Mecham, Jessica E. Wagenseil
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2020)
Editorial Material
Biology
Jessica E. Wagenseil, Karen M. Downs
Article
Mechanics
Young Guang, Austin J. Cocciolone, Christie L. Crandall, Benjamin B. Johnston, Lori A. Setton, Jessica E. Wagenseil
Summary: Transport of solute across the arterial wall is influenced by convection, diffusion, and disruption of elastic fibers. A computational mixture model was used to study these changes, with results showing that elastic fiber structure affects the transport of lower molecular weight solutes.
ARCHIVE OF APPLIED MECHANICS
(2022)
Review
Cell Biology
Chien-Jung Lin, Austin J. Cocciolone, Jessica E. Wagenseil
Summary: Elastin is an important protein that provides elasticity to the arterial wall, allowing it to stretch and recoil. Changes in the amount and assembly of elastin can lead to alterations in arterial structure and mechanical behavior, affecting cardiovascular function.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Hematology
Chien-Jung Lin, Bridget M. Hunkins, Robyn A. Roth, Chieh-Yu Lin, Jessica E. Wagenseil, Robert P. Mecham
Summary: This study investigates the mechanism of neointima formation due to Eln insufficiency in a mouse model, showing that cells from the secondary heart field are significant contributors to intimal hyperplasia. Two unique SMC populations were identified in the neointima of SMC-Eln knockout mice, suggesting shared mechanisms with adult vessel injury models.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Engineering, Biomedical
Jungsil Kim, Austin J. Cocciolone, Marius C. Staiculescu, Robert P. Mecham, Jessica E. Wagenseil
Summary: The study conducted passive biaxial mechanical testing on newborn mouse aorta, finding that Eln-/- aorta generally predicted lower material constants, lower circumferential stresses and moduli compared to Eln+/+ aorta, with increased blood pressure helping to alleviate the differences.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Engineering, Biomedical
Christie L. Crandall, Bryant Caballero, Mariana E. Viso, Naren R. Vyavahare, Jessica E. Wagenseil
Summary: This study found that pentagalloyl glucose (PGG) may be a pharmaceutical option to stabilize elastic fibers in thoracic aortic aneurysm (TAA). The results suggest that PGG treatment can prevent and restore the mechanical and structural changes caused by elastic fiber degradation in TAA.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Christie L. Crandall, Yufan Wu, Keshav A. Kailash, Mathew R. Bersi, Carmen M. Halabi, Jessica E. Wagenseil
Summary: Thoracic aortic aneurysm is characterized by dilation of the aortic diameter by greater than 50%, which can lead to dissection or rupture. This study found that aneurysm severity in the ascending thoracic aorta is associated with changes in mass transport parameters and extracellular matrix organization. The results suggest that an initial increase in solute permeability is followed by a decrease in hydraulic conductance after the aneurysm has formed. Elastic fiber fragmentation is also observed in the extracellular matrix, which could contribute to aneurysm progression or treatment options.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)