Editorial Material
Multidisciplinary Sciences
J. Pedro de Souza, Howard A. Stone
Summary: Protein condensation can not only form membraneless organelles, but also regulate the availability of water.
Article
Multidisciplinary Sciences
Hugo Wioland, Antoine Jegou, Guillaume Romet-Lemonne
Summary: This article summarizes the experimental method of using optical microscopy to observe individual events on individual actin filaments in real time, and discusses its application in understanding actin assembly dynamics. The article also proposes a set of guidelines in order to better utilize this experimental tool.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Loretta Akakpo, Edward Ntim Gasu, Jehoshaphat Oppong Mensah, Lawrence Sheringham Borquaye
Summary: This study used molecular docking and molecular dynamics simulations to explore the inhibitory activity of some natural products against Plasmodium falciparum dihydrofolate reductase (PfDHFR). Two compounds were found to have stable binding and could be considered as potential antifolate agents.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Jasmine A. Nirody, Lisset A. Duran, Deborah Johnston, Daniel J. Cohen
Summary: The study found that tardigrades exhibit key features of walking similar to insects and show flexibility in interleg coordination under different environmental conditions. This suggests functional similarities in walking coordination between tardigrades and arthropods, possibly due to a common locomotor control circuit or independent convergence onto an optimal control strategy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Chemistry, Multidisciplinary
Ron Elber, Arman Fathizadeh, Piao Ma, Hao Wang
Summary: Time scales play a crucial role in biology, where living systems exploit variations in time scales to direct processes in desired directions. Molecular Dynamics simulations and the method of Milestoning are utilized to study dynamics of biophysical processes and enhance sampling of kinetic events, offering comprehensive pictures of complex biomolecular reactions.
WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Erick Rafael Dias Rates, Charles Duarte Almeida, Elaine de Paula Fiod Costa, Roberta Jansen de Mello Farias, Ralph Santos-Oliveira, Luciana Magalhaes Rebelo Alencar
Summary: This study used atomic force microscopy (AFM) to evaluate four layers of the cornea and analyze their adhesion, stiffness, and roughness. The findings revealed microvilli in the epithelial and endothelial layers, pores in the basement membrane, and collagen fibers in the stroma. These data contribute to a better understanding of the ultrastructures of the human cornea layers and provide new information about their biophysical properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Multidisciplinary Sciences
Marina. G. G. Guenza
Summary: Many biological processes rely on protein aggregates that have dynamic behaviors spanning different scales. A clever combination of spectroscopy and simulation can be used to investigate these diverse dynamics.
Article
Sport Sciences
Leigh Gabel, Anna-Maria Liphardt, Paul A. Hulme, Martina Heer, Sara R. Zwart, Jean D. Sibonga, Scott M. Smith, Steven K. Boyd
Summary: The study revealed that long-duration spaceflight leads to significant decreases in bone density and strength in astronauts, while pre-flight markers of bone turnover and exercise history can help identify individuals at risk for bone loss. Additionally, increasing training volume can help prevent loss of bone strength and density.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Article
Multidisciplinary Sciences
Krystian Toczewski, Sylwester Gerus, Maciej Kaczorowski, Marta Kozun, Justyna Wolicka, Kamila Bobrek, Jaroslaw Filipiak, Dariusz Patkowski
Summary: This study aimed to determine the best type of traction suture for esophageal lengthening using an animal model. Pledget suture showed the highest maximal force and allowed for the greatest elongation. Intermittent traction method resulted in better elongation compared to constant traction if traction was maintained during breaks.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Chemical
Yue Liang, Wenjuan Wang, Yan Sun, Xiaoyan Dong
Summary: Inhibition of protein misfolding and aggregation is a major challenge in biochemical and biopharmaceutical engineering. This study investigated the coaggregation and seeding interactions between AB40 and AB11-40, as well as the effect of the small molecule inhibitor EGCG on amyloid aggregation. The results showed that AB11-40 participates in the aggregation of AB40 and that EGCG inhibits both AB isoforms mainly through hydrophobic interactions. These findings provide new insights into AB aggregation and have implications for the development of inhibitors against amyloid protein co-assembly.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Cell Biology
Apurva A. Govande, Brianna Duncan-Lowey, James B. Eaglesham, Aaron T. Whiteley, Philip J. Kranzusch
Summary: The study identifies molecular rules controlling CD-NTase specificity, with correct nucleotide selection resulting in a thermostable protein-nucleotide complex. Specific patterns governing selectivity for each major bacterial CD-NTase clades are established. These results explain CD-NTase specificity and enable predictions of nucleotide second-messenger signals within diverse antiviral systems.
Review
Biochemistry & Molecular Biology
Alissa Drees, Markus Fischer
Summary: The HiTS-FLIP technology improves the efficiency of aptamer selection, providing insights into the relationship between sequence, structure, and function, which supports the evolution of aptamers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Matthias Jakob, Wolfgang Gindl-Altmutter
Summary: Due to improvements in the mechanical performance of solid wood, densification after partial or full delignification has gained attention. However, systematic investigations on the effect of wood structure on densification process are lacking. This study compared the deformation patterns of spruce and poplar in transverse compression, considering different conditions. It was found that the structural inhomogeneity of spruce hinders defect-free densification, while the homogeneous structure of poplar, along with effective delignification, leads to favorable densification behavior.
JOURNAL OF MATERIALS SCIENCE
(2023)
Editorial Material
Multidisciplinary Sciences
Debora S. Marks, Stephen W. Michnick
Summary: An integrated technique is introduced to quantify and disentangle the effects of gene mutations on protein traits, allowing assessments of mutational effects on protein biophysics.
Article
Chemistry, Multidisciplinary
Maria Fernanda Candela, Nelson E. Arenas, Obradith Caicedo, Andres Malagon
Summary: The study investigated the inhibition of porcine pancreatic lipase by the drug orlistat using a combination of experimental and computational methods. Docking calculations were recommended to understand enzyme-ligand interactions and the inhibitor mechanism of action, while sequence analysis was used to compare enzyme structures across different organisms. Additionally, an educational project proposed for biochemistry or pharmacy students can enhance understanding of enzyme kinetics, binding sites, and enzyme-ligand interactions through visualizations.
JOURNAL OF CHEMICAL EDUCATION
(2021)
Article
Biochemistry & Molecular Biology
Jonathan W. Bourne, Peter A. Torzilli
Article
Biochemistry & Molecular Biology
Jonathan W. Bourne, Jared M. Lippell, Peter A. Torzilli
Article
Multidisciplinary Sciences
Olivera Stojadinovic, Julia Minkiewicz, Andrew Sawaya, Jonathan W. Bourne, Peter Torzilli, Juan Pablo de Rivero Vaccari, W. Dalton Dietrich, Robert W. Keane, Marjana Tomic-Canic
Review
Oncology
Peter A. Torzilli, Jonathan W. Bourne, Tessa Cigler, C. Theresa Vincent
SEMINARS IN CANCER BIOLOGY
(2012)
Article
Engineering, Biomedical
Jonathan W. Bourne, Lei Shi, Peter A. Torzilli
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Proceedings Paper
Engineering, Biomedical
Jonathan W. Bourne, Jared M. Lippell, Peter A. Torzilli
PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B
(2012)
Proceedings Paper
Cell & Tissue Engineering
Jonathan W. Bourne, Peter A. Torzilli
PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2009, PT A AND B
(2009)
Article
Materials Science, Ceramics
Kazushige Yokoyama, Bradley E. Johnson, Jonathan W. Bourne
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2007)
Article
Genetics & Heredity
W Li, M He, HL Zhou, JW Bourne, P Liang