Article
Chemistry, Multidisciplinary
Chun-Nan Zhu, Mei-Yu Lv, Fei Song, Dong-Yun Zheng, Chao Liu, Xiao-Jun Liu, Dong-Bing Cheng, Zeng-Ying Qiao
Summary: In this study, reversible covalent nanoassemblies were synthesized for the delivery of DOX and TQR, which could overcome tumor MDR by improving nuclear drug accumulation. These nanoassemblies showed efficient tumor suppression efficacy in multidrug-resistant tumor models.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Changduo Wang, Fashun Li, Tianao Zhang, Min Yu, Yong Sun
Summary: Chemotherapy often fails due to drug resistance. To overcome this, researchers have developed a functional nano-drug delivery system (NDDS) that enhances the sensitivity of anticancer drugs and reduces side effects. This review explores the causes of multidrug resistance (MDR), highlights the applications of NDDS, and discusses future directions in this field.
Article
Materials Science, Multidisciplinary
Sinan Cheng, Zheng Lu, Yang Feng, Xuewei Zhao, Ruixia Zhao, Zuchun Qiu, Chenshuang Jia, Lirong Chen, Yue Yuan, Xinyao Li, Qian Gao, Jie Xu, Zhan Shu, Wei Duan, Yingchun Hou, Guochao Nie, Li Xiao
Summary: Breast cancer is the most common cancer and leading cause of death in women. Current chemotherapy has low efficacy and high side effects, necessitating the development of a novel targeted drug delivery formulation. The study discovered a new drug formulation that showed satisfactory therapeutic efficacy for breast cancer, particularly for drug resistant cases.
MATERIALS TODAY ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Jie Mi, Dandan Cui, Zhenhui Zhang, Gen Mu, Yujiao Shi
Summary: This study presents a femtosecond-laser-pumped ultrafast photoacoustic cavitation technique using nanoprobes coated with polyvinylpyrrolidone-40000 (PVP). The technique allows for sustainable and highly efficient shockwave theranostics, overcoming the limitations of nanodroplets. The experiments demonstrate significant anti-tumor effects and potential clinical applications.
Article
Chemistry, Multidisciplinary
Jie Mi, Dandan Cui, Zhenhui Zhang, Gen Mu, Yujiao Shi
Summary: This study proposes a femtosecond-laser-pumped ultrafast photoacoustic cavitation technique that relies on nanomaterials to overcome the limitations of existing methods. The experimental results demonstrate the effectiveness and precision of this method in inhibiting tumor growth, highlighting its significance in the field of photoacoustic theranostics.
Article
Chemistry, Multidisciplinary
Dingkang Liu, Ye Chen, Qun Wang, Yue Ji, Lichen Bao, Wenbing Yao, Xiangdong Gao, Jun Yin
Summary: In this study, a multifunctional fusion protein-DNA conjugate was developed as a co-delivery vehicle for anticancer peptides and chemotherapeutic drugs. The tailored nanostructure showed enhanced stability, tumor targeting, and controlled-release properties, allowing selective entry into tumor cells and synergistic antitumor activity with no significant adverse effects.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Chih-Peng Lin, Shu-Hui Wu, Tzu-Yin Lin, Chia-Hui Chu, Leu-Wei Lo, Ching-Chuan Kuo, Jang-Yang Chang, Szu-Chun Hsu, Bor-Sheng Ko, Ming Yao, Jong-Kai Hsiao, Shih-Wei Wang, Dong-Ming Huang
Summary: This study develops a simple and versatile biological drug delivery system (bDDS) based on human red blood cell-derived vesicles (RDVs), which shows excellent biocompatibility for cancer chemotherapy. The bDDS, named Dox-gluRDVs, effectively suppress multidrug resistance in uterine sarcoma by inducing cell death through a lysosomal-mitochondrial axis-dependent mechanism.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Physical
Haofei Zhou, Ye Yuan, Zhexu Wang, Zexin Ren, Mixia Hu, JingKun Lu, Hongxia Gao, Cheng Pan, Wenjie Zhao, Baohua Zhu
Summary: This study has developed a novel nanoplatform for delivering chemotherapy drugs and overcoming multidrug resistance. By using a combination strategy of quercetin and doxorubicin and utilizing the high-speed motion of the motor, this nanoplatform can increase the intracellular accumulation of drugs and enhance the killing effect on multidrug-resistant cells.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Engineering, Biomedical
Yang Yang, Kaiqi Long, Yiqun Wang, Lei Li, Jiayue Shi, Jican Liu, Lingxi Kong, Lin Yu, Jiandong Ding, Zhili Huang, Weiping Wang, Changyou Zhan
Summary: This study introduces a technique for drug release triggered by near infrared light, achieving quantitative pulsed drug release by loading photocleavable prodrugs into hydrogels. This system demonstrates characteristics of good stability, visible drug release process, and efficient light responsiveness.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Medicine, Research & Experimental
Xiao Wei, Mingzhu Song, Weijie Li, Jing Huang, Guang Yang, Yi Wang
Summary: The primary cause of chemotherapy failure is cancer multidrug resistance (MDR), leading to recurrence and metastasis of cancer. Dual-therapeutic combination using multifunctional nanoplatforms is gaining attention for overcoming resistant cancers. Smart co-delivery nanocarriers can improve drug properties, enhance therapeutic efficacy, and even overcome drug resistance.
Review
Pharmacology & Pharmacy
Vernon LaLone, Doug Smith, Jennifer Diaz-Espinosa, Gus R. Rosania
Summary: Raman confocal microscopes are used to visualize the distribution of small molecule drugs within cells, providing insights into their transport phenomena. Chemical imaging techniques reveal the formation of stable complexes or precipitates of lipophilic drugs inside cells. Raman chemical imaging methods allow measurement and mapping of drug molecules at a microscopic, subcellular level.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biotechnology & Applied Microbiology
Wenrui Wang, Mengyang Zhou, Yang Xu, Wei Peng, Shiwen Zhang, Rongjie Li, Han Zhang, Hui Zhang, Shumin Cheng, Youjing Wang, Xinyu Wei, Chengxu Yue, Qingling Yang, Changjie Chen
Summary: The study successfully formulated TPGS-Res-SLNs nanoparticles to improve therapeutic efficacy against breast cancer, showing significant anti-tumor activity and promotion of cell apoptosis. It also exhibited significant inhibition of cancer cell invasion and migration. In vivo experiments showed that TPGS-Res-SLNs had higher efficacy in promoting tumor cell apoptosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Sunil Kumar Dubey, Maithili Kali, Siddhanth Hejmady, Ranendra Narayan Saha, Amit Alexander, Prashant Kesharwani
Summary: Breast Cancer is a highly heterogeneous malignant carcinoma that affects women, and conventional therapies include chemotherapy, hormonal therapy, radiation, and nanotechnology. Dendrimers play a significant role in addressing the toxicity and resistance of chemotherapeutic agents in BC, with high loading capacity and targeted drug delivery capabilities.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Patrick M. Perrigue, Richard A. Murray, Angelika Mielcarek, Agata Henschke, Sergio E. Moya
Summary: Nanoformulations offer advantages in enhancing drug solubility, biocompatibility, and bioavailability, reducing side effects. Despite limited research on stability and degradation of nanocarriers in biological environments, techniques exist for tracing the fate of nanocarriers, including their degradation and drug release intra- and extracellularly. Fluorescence techniques and nuclear imaging are commonly used to track nanocarriers in research on nanoformulations.
Article
Nanoscience & Nanotechnology
Jianping Hu, Yingying Jiang, Shuo Tan, Kunpeng Zhu, Tao Cai, Taicheng Zhan, Shisheng He, Feng Chen, Chunlin Zhang
Summary: The study demonstrates the potential of selenium-doped calcium phosphate biomineral (Se-CaP) in reversing multidrug resistance in bone tumors, with high biocompatibility, biodegradability, and pH-sensitive drug release properties. Se-CaP can serve as an effective drug carrier and induce apoptosis in osteosarcoma by generating intracellular reactive oxygen species.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Review
Oncology
Bumsoo Han, Chunjing Qu, Kinam Park, Stephen F. Konieczny, Murray Korc
Article
Biochemistry & Molecular Biology
Feiran Li, Tae-Gon Cha, Jing Pan, Altug Ozcelikkale, Bumsoo Han, Jong Hyun Choi
Article
Thermodynamics
Bumsoo Han, Gyu Young Yun, J. William Boley, Samuel Haidong Kim, Jun Young Hwang, George T. -C. Chiu, Kinam Park
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2016)
Article
Materials Science, Multidisciplinary
Soham Ghosh, Guoping Xiong, Timothy S. Fisher, Bumsoo Han
Article
Chemistry, Multidisciplinary
Altug Ozcelikkale, Kyeonggon Shin, Victoria Noe-Kim, Bennett D. Elzey, Zizheng Dong, Jian-Ting Zhang, Kwangmeyung Kim, Ick Chan Kwon, Kinam Park, Bumsoo Han
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Multidisciplinary Sciences
Altug Ozcelikkale, J. Craig Dutton, Frederick Grinnell, Bumsoo Han
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2017)
Article
Biochemistry & Molecular Biology
Youyun Liang, Nicholas Edwin Clay, Kathryn M. Sullivan, Jiayu Leong, Altug Ozcelikkale, Max H. Rich, Min Kyung Lee, Mei-Hsiu Lai, Hojeong Jeon, Bumsoo Han, Yen Wah Tong, Hyunjoon Kong
MACROMOLECULAR BIOSCIENCE
(2017)
Article
Physics, Multidisciplinary
Julien Varennes, Sean Fancher, Bumsoo Han, Andrew Mugler
PHYSICAL REVIEW LETTERS
(2017)
Review
Nanoscience & Nanotechnology
Altug Ozcelikkale, Hye-ran Moon, Michael Linnes, Bumsoo Han
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2017)
Article
Biochemical Research Methods
Taylor J. Thompson, Bumsoo Han
Article
Multidisciplinary Sciences
Qiaoqiao Wan, ThucNhi TruongVo, Hannah E. Steele, Altug Ozcelikkale, Bumsoo Han, Yingxiao Wang, Junghwan Oh, Hiroki Yokota, Sungsoo Na
SCIENTIFIC REPORTS
(2017)
Article
Biochemical Research Methods
Julien Varennes, Hye-ran Moon, Soutick Saha, Andrew Mugler, Bumsoo Han
PLOS COMPUTATIONAL BIOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Michael J. Bradney, Stephanie M. Venis, Yi Yang, Stephen F. Konieczny, Bumsoo Han
Article
Thermodynamics
Cih Cheng, Yoon Jae Moon, Samuel Haidong Kim, Yong-Cheol Jeong, Jun Young Hwang, George T-C Chiu, Bumsoo Han
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2020)
Article
Nanoscience & Nanotechnology
Yongbeom Seo, Jiayu Leong, Jye Yng Teo, Jennifer W. Mitchell, Martha U. Gillette, Bumsoo Han, Jonghwi Lee, Hyunjoon Kong
ACS APPLIED MATERIALS & INTERFACES
(2017)