Review
Biochemistry & Molecular Biology
Pulikanti Guruprasad Reddy, Abraham J. Domb
Summary: Polyanhydrides (PAs) are synthetic biodegradable polymers used as controlled drug delivery vehicles. They are biocompatible, biodegradable, and generate nontoxic metabolites upon degradation. PAs have surface-eroding characteristics and have been developed into various drug delivery carriers. The rate of drug delivery is controlled by the polymer erosion rate, which is influenced by the polymer structure and composition, hydrophobicity, pH of the release medium, and device size.
Article
Chemistry, Multidisciplinary
Lorenzo Biancalana, Michele De Franco, Gianluca Ciancaleoni, Stefano Zacchini, Guido Pampaloni, Valentina Gandin, Fabio Marchetti
Summary: A straightforward two-step procedure was developed to convert commercial materials into anticancer ionic complexes via CO removal, which showed promising antiproliferative activity against human cancer cell lines. These complexes also displayed significant cytotoxic activity against human cancer 3D cell cultures.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Polymer Science
Xianshuo Zhang, Peipei Wang, Yaoyu Xu, Jun Wang, Yunfeng Shi, Wenxu Niu, Wenjing Song, Ruru Liu, Cui-Yun Yu, Hua Wei
Summary: A robust yet facile strategy for the synthesis of biodegradable hyperbranched amphiphilic copolymers is reported in this study. The block-statistical structure is identified as a better polymer architecture for controlled release applications.
Article
Chemistry, Multidisciplinary
Liu Tan, Jinling Fan, Yuqing Zhou, Di Xiong, Manzhen Duan, Ding Hu, Zhimin Wu
Summary: A new type of reversible cross-linked and pH-responsive polymeric micelle was synthesized for targeted delivery of curcumin. The micelle exhibited excellent stability and reversibility of pH-responsiveness in solutions with different pH values. Simulation methods were employed to investigate the self-assembly process and pH-responsive behavior of the micelle.
Article
Polymer Science
Takaya Ikami, Yuki Watanabe, Hiroki Ogawa, Mikihito Takenaka, Norifumi L. Yamada, Makoto Ouchi, Hiroyuki Aoki, Takaya Terashima
Summary: By controlling the composition of the copolymers with octadecyl groups and hydroxyethyl groups in solution, ordered lamellar structures can be formed in the solid state, while spin-coating the polymer solutions onto silicon substrates allows the copolymers to autonomously form multilayered lamellar thin films.
Article
Biochemistry & Molecular Biology
Monika Owczarek, Lucyna Herczynska, Przemyslaw Sitarek, Tomasz Kowalczyk, Ewelina Synowiec, Tomasz Sliwinski, Izabella Krucinska
Summary: Nanoparticles, particularly those made of chitosan, have been widely studied in nanotechnology and have shown great potential in medicine. Chitosan nanoparticles with Ginkgo biloba extract (GBE) were successfully synthesized using ion gelation method. The nanoparticles exhibited excellent encapsulation efficiency and released GBE in a controlled manner. Biological studies demonstrated the cytotoxic effects of GBE and chitosan nanoparticles on tumor cells, while no cytotoxicity was observed on normal cells.
Article
Toxicology
Sarah McCarrick, Valentin Romanovski, Zheng Wei, Elin M. Westin, Kjell-Arne Persson, Klara Trydell, Richard Wagner, Inger Odnevall, Yolanda S. Hedberg, Hanna L. Karlsson
Summary: The study demonstrates that welding particles generated using optimized Cr(VI)-reduced wires are less toxic compared to standard welding wires, showing reduced cytotoxicity and no DNA damage. The release of Cr(VI) from standard wires in cell media seemed to explain most of the cytotoxicity and DNA damage. Different welding particles caused similar inflammatory effects, suggesting different underlying mechanisms.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Liandong Ye, Min Liu, Xiao Wang, Zhihong Yu, Zhihao Huang, Nianchen Zhou, Zhengbiao Zhang, Xiulin Zhu
Summary: In this study, discrete amphiphilic co-oligomers with the same composition but different building blocks were reported. These sequence-defined oligomers became amphipathic due to quaternization of the amine groups in acidic aqueous solution. Under the same conditions, these oligomer isomers self-assembled into different nanoparticles, including nanofibers, hollow vesicles, and spherical micellar complexes. This work demonstrates the customization of functional nanoparticles through sequence structure control in synthetic co-oligomers.
Article
Biochemistry & Molecular Biology
Richard Behnke, Franka Stahl, Kathrin Duske, Mareike Warkentin, Margit Schwartz, Burkhard Hinz, Udo Walther
Summary: Depending on their composition, plastics can have varying cytotoxic potential, which is influenced by soaking time and specimen thickness. Some plastics can reduce cytotoxic effects under specific conditions, while increasing specimen thickness may increase cytotoxicity. Polypropylene shows good biocompatibility.
Article
Pharmacology & Pharmacy
Musaed Alkholief, Mohd Abul Kalam, Md Khalid Anwer, Aws Alshamsan
Summary: The study shows that using different ratios of stabilizers and solvents to prepare PLGA-NPs can affect the physical and chemical properties of the nanoparticles, while optimal drug encapsulation can be achieved by combining 40 mg PLGA and 4 mg IND in 1 mL DCM/chloroform with PVA/PVP (1-3%).
Article
Polymer Science
Yanyao Zhang, Yusheng Tang, Junliang Zhang, Simon Harrisson
Summary: The fluorescence properties of the copolymer can be adjusted by rationally designing the copolymer structure. The asymmetric diblock copolymer shows a gradual increase in fluorescent intensity as the environmental pH decreases, in contrast to the limited and stepwise change of its symmetric block counterpart.
Article
Materials Science, Multidisciplinary
Christopher B. Keller, Julia S. Siqueira, Scott M. Grayson
Summary: This study expands upon previous work on amphiphilic-grafted nanoparticles and investigates their oil encapsulation properties through UV and DSC analysis. The results suggest that these nanoparticles can encapsulate a significant amount of crude oil and do not have a critical micelle concentration.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Materials Science, Textiles
Fatma Nur Parin, Cigdem Inci Aydemir, Gokce Taner, Kenan Yildirim
Summary: In this study, hydrophilic based bioactive nanofibers were produced via an electrospinning and electrospraying simultaneous process. The morphology, thermal behavior, and chemical structure of the composite nanofibers were investigated, showing fast release of folic acid-loaded fibers. Biocompatibility assessments revealed the potential of these nanofibers for transdermal patch applications, especially in skincare products.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Article
Polymer Science
Yingqi Mi, Jingjing Zhang, Lulin Zhang, Qing Li, Yuanzheng Cheng, Zhanyong Guo
Summary: Chitosan nanoparticles loaded with adriamycin exhibited a burst effect followed by steady release, and demonstrated enhanced antioxidant activities and cytotoxicities against cancer cells. With reduced cytotoxicity and enhanced biological activity, these novel nanoparticles could serve as promising candidates for drug loading/release in drug delivery systems.
Article
Materials Science, Ceramics
S. K. Alla, A. Gangwar, S. K. Shaw, M. K. Viswanadh, K. Neogi, M. S. Muthu, Nidhi Gupta, Sher Singh Meena, P. Kollu, R. K. Mandal, N. K. Prasad
Summary: High resolution TEM studies revealed the spherical morphology of MxCe1-xO2 (M = Co, Fe or Ti, x = 0.05) nanoparticles with sizes ranging from 8-11 nm. The in-vitro cytotoxicity study demonstrated that Co-doped CeO2 nanoparticles showed higher biocompatibility against human lung adenocarcinoma cells. The concentration of vacancies in the samples was found to have an impact on the free radical scavenging effect and biocompatibility.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Mehlika Karamanlioglu, Serap Yesilkir-Baydar
Summary: This study determined the influence and ideal ratios of different amounts of coconut oil in gelatin-based films as wound dressings. Increasing coconut oil content improved the mechanical properties, thermal stability, cell viability, and wound healing ability of the films. CO-2 and CO-4 showed the best performance among the samples.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Yu-Min Chen, Chihoko Tokoda, Yasuhiko Tabata
Summary: The objective of this study is to establish strategies to uniformly proliferate cells in a three-dimensional nonwoven PET/EVOH scaffold by simple adjustments in seeding and culture methods and the scaffold design. The combination of dynamic and static seeding methods resulted in the highest seeding efficiency. Stirring culture allowed cells to proliferate to a greater extent, while opening holes in the scaffold improved cell distribution. Two 1-mm holes were found to be optimal for homogeneous cell proliferation. Different cell types showed similar behavior in the scaffold, indicating the applicability of the established procedure. The nonwoven PET/EVOH scaffold serves as a potential cell culture substrate for efficient cell proliferation.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Majid Saeedi, Katayoun Morteza-Semnani, Jafar Akbari, Seyyed Mobin Rahimnia, Fatemeh Ahmadi, Hanieh Choubdari, Amir Lotfi, Seyyed Mohammad Hassan Hashemi
Summary: In this study, kojic acid loaded chitosan/collagen nanoparticles were produced using an ionic gelation and ultrasonic approach to enhance dermal delivery and anti-pigmentation effects. Increasing the amount of collagen in the nanoparticles led to larger particle size and higher entrapment efficiency of kojic acid. The nanoparticles were found to be spherical in shape and kojic acid was in an amorphous form. Skin permeability tests showed that the nanoparticles delivered more kojic acid to the dermal layers compared to plain gel. The nanoparticles were non-toxic and non-irritating, and exhibited stronger inhibition of melanin formation compared to free kojic acid. These findings suggest that the produced nanoparticles have potential as a nano-vehicle for dermal administration of kojic acid, providing new options for managing hyper-melanogenesis problems.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Hue Thi Nguyen, Anh-Tuan Le, Thanh Thuy Nguyen, Tran Quang Huy, Thuy Thi Thu Nguyen
Summary: In this study, a chitosan and emodin formulation was prepared to enhance the solubility of emodin and exhibited synergic antibacterial activity against drug-resistant bacterial strains. The enhanced solubility of the formulation suggests its potential as a candidate for the treatment of infectious diseases caused by drug-resistant bacterial pathogens.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)
Article
Engineering, Biomedical
Jiu Ge, Mengting Li, Jiahui Fan, Christian Celia, Yijun Xie, Qing Chang, Xiaoyong Deng
Summary: Bacterial infections pose a significant threat to human health, and the emergence of multidrug-resistant bacteria has reduced the effectiveness of antibacterial treatments. In this study, chitosan/silver nanoparticle complexes were developed to inhibit bacterial proliferation and induce membrane damage. The results demonstrated that increasing the chitosan concentration enhanced the antibacterial impact, and the nanoparticles showed broad-spectrum antimicrobial activity. The study provides valuable insights into the development of nano-antibacterial agents as a potential substitute for traditional antibiotics in medical applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2024)